381 research outputs found

    Parrot damage to bluegum tree crops : a review of the problem and possible solutions

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    Damage to Bluegum (Eucalyptus globulus) tree crops by the Twenty-eight Parrot (Barnardius zonarius) is emerging problem which could threaten the viability of the infant Bluegum industry in south-western Australia. The parrots strip bark from the lead shoot of the Bluegums causing the shoots to break off. Consequently lateral shoots develop resulting in deformed (bent or multi-stem) trees unsuited to harvest and utilisation.Indications that the reason Twenty-eight Parrots strip bark from Bluegum is to obta behaviour\u27 and hence the damage may also develop in areas where it is absent or uncommon now. Currently the zone of worst damage includes around 20% of the total area suitable for Bluegum planting in south-west Australia.There is a \u27critical period\u27 for controlling parrot damage. At monitoring sites this was found to start in March of the first year after planting and end around July of the second year after planting

    The Basis of VCP-Mediated Degeneration: Insights From a Drosophila Model of Disease

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    Valosin-containing protein (VCP) is a highly conserved molecular chaperone that regulates a wide array of essential cellular processes. Mutations in VCP are causative of degenerative disease that can affect muscle, brain and bone. Despite VCP being implicated in many major pathways in the cell, the mechanism of disease pathogenesis is unknown. To gain insight into the degeneration associated with mutations in VCP, we developed and characterized a Drosophila model of disease that recapitulated VCP mutation-dependent toxicity. VCP is involved in a diverse array of activities, many of which we may not know. Therefore we employed an unbiased genetic screening method that has the potential to uncover unanticipated pathways affected in the disease. Using this approach, we identified four proteins that dominantly suppressed degeneration; one of which was Ube4b, one of the many known ancillary proteins that bind to VCP and determine its function. The three remaining dominant modifiers identified were all RNA-binding proteins including TBPH, the Drosophila orthologue of TAR (trans-activating response region) DNA-binding protein (TDP-43). TDP-43 has been identified as a major component of the ubiquitinated inclusions characteristic of an emerging spectrum of proteinopathies, including degeneration associated with VCP mutations. Redistribution of TDP-43 from the nucleus to the cytoplasm has been demonstrated in these proteinopathies but the significance of this was unknown. Here we demonstrated that TDP-43 and VCP interact genetically and disease-causing VCP mutations led to redistribution of TDP-43 to the cytoplasm in vitro and in vivo, replicating the major pathology observed in TDP-43 proteinopathies. Furthermore, we demonstrated that TDP-43 redistribution is sufficient to induce cytotoxicity. Together our results show that degeneration associated with VCP mutations is mediated, in part, by toxic gain of function of TDP-43 in the cytoplasm where its redistribution is possibly due to the altered binding repertoire of VCP. This work acts to further our understanding of the pathogenic mechanism of, not only VCP-related disease but also a broad array of TDP-43 proteinopathies that include frontotemporal dementia, inclusion body myopathies and amyotrophic lateral sclerosis

    The use of historical accounts of species distribution to suggest restoration targets for UK upland mires within a ‘moorland’ landscape

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    Using contemporary accounts of vegetation in the South Pennine landscape of northern England from the late 18th Century to the present day, we describe the degradation and subsequent partial recovery of these upland mire systems in terms of their vegetation biodiversity. The historical sources highlight several species that were once common on these peatlands but which do not currently feature as positive indicator species in monitoring or restoration programmes. The use of archival sources may provide additional evidence that complements palaeoecological data when setting restoration targets. For example, the historical accounts support the palaeoecological timeline for the disappearance of Sphagnum from these landscapes. As a step toward a possible expanded set of targets for restoration works, we suggest an extended list of positive indicator species for the South Pennines which could also be applicable elsewhere in the UK. These include species such as lesser twayblade (Neottia cordata) and the club mosses (Lycopodiaceae), which were noted to be common in the 18th and 19th centuries, but which had become rare by the early 20th century. We highlight changes in land ownership and land use through the process of enclosure, as well as indirect effects from industrialisation, as the dominant interacting drivers of vegetation change

    Determining consumer expectations, attitudes and buying behaviour towards “low input” and organic foods

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    This paper reviews the first results and achievements of the QLIF SP1 “Determining consumer expectations and attitudes towards organic/low input food quality and safety”. The paper aims to illustrate the array of methodologies used and to discuss the ongoing research in light of the first results

    Tortious Necessity; The Privileged Defense

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    The similarities between the laws of torts in the United States of America and England enable one to make an interesting comparison between the two sets of rules applicable to the general defense of necessity. Although both tort systems are derivatives to a greater or lesser extent of the English common law, they have inevitably developed their own individual jurisprudence over the years. Concepts have been refined and extended to produce significant and curious differences which provide an interesting exercise in legal forensic. The similarities of the two tort systems make a comparative study possible, and the differences provide the justification for the analysis

    Policy instruments in the Common Agricultural Policy

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    Policy changes in the Common Agricultural Policy (CAP) can be explained in terms of the exhaustion and long-term contradictions of policy instruments. Changes in policy instruments have reoriented the policy without any change in formal Treaty goals. The social and economic efficacy of instruments in terms of evidence-based policy analysis was a key factor in whether they were delegitimized. The original policy instruments were generally dysfunctional, but reframing the policy in terms of a multifunctionality paradigm permitted the development of more efficacious instruments. A dynamic interaction takes place between the instruments and policy informed by the predominant discourses

    Masculinity as Governance: police, public service and the embodiment of authority, c. 1700-1850

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    About the book: Public Men offers an introduction to an exciting new field: the history of masculinities in the political domain and will be essential reading for students and specialists alike with interests in gender or political culture. By building upon new work on gender and political culture, these new case studies explore the gendering of the political domain and the masculinities of the men who have historically dominated it. As such, Public Men is a major contribution to our understanding of the history of Britain between the Eighteenth and the Twentieth centuries
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