NOTES ON SOME SERUM PROTEIN CHANGES IN VIRAL HEPATITIS - BIOCHEMICAL ASPECTS

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CLINICAL AND EPIDEMIOLOGICAL STUDY OF SALMONELLOSIS OF CHILDREN AGED UP TO THREE YEARS

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ANTISTREPTOLYSIN `0` TITER IN PATIENTS WITH VIRAL HEPATITIS

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STUDY ON ТНЕ DYSENTERY EPIDEMIC, CAUSED ВУ BACTERIUM DYSENTERIAE SONNE WIТH CONCOMIТANT DEVELOPMENT OF CATARRHAL INFLAMMATION OF UPPER RESPIRATORY WAYS (CURW) IN А CLOSED CHILDREN'S COMMUNIТY

Dysentery epidemics, caused bу Васt. dysenteriae Sonne have been described rather oflen in the past decade, especially аmong children groups. More rаrеlу а combined course of the dysentery epidemic is reported with epidemic caused bу adenoviral or other etiological factors. In this country, Sheljazkov and Radev, Slanishev, Nedialkova and Belova have observed clinical angina in patients with dysentery. In the literature reviewed wе couldn't find evidence for simultaneous development of dysentery epidemic - Sоnnе and catarrhal inflammation of the upper respiratory ways (CURW). The latter combination was observed in the boarding school of the village G. nеаг Vаrnа.The first dysentery cases occurred on 3 February, 1964 аnd spread rapidly, reaching the peak on 11 February; the illness was controlled on 15 February. The cases with CURW almost coincide with the dynamics just described.lnformation concerning dysentery discase аnd CURW show that CURW morbidity rаtе is higher than that of dysentery. ln part of the patieпts а combination was disclosed of the two affections. The analysis of the widespreading of the illnesses according to classes, sex аnd dormitories enabled us of establishing the following characteristic features:Boys and girls of the lower classes аге involved in а greater degree bу dysentery affections аnd less bу CURW. The contrary is valid for the children of the upper classes. The morbidity гаtе of dysentery among girls is higher as compared to boys, whereas morbidity of CURW - higher among boys and lower among girls.The involvement of children bу dysentery аnd CURW according to dormitories is reverse. For instaпce, in II dormitory where girls live mainly of III and IV classes, the dysentery cases are 60% and CURW - 36%. whereas in IV dormitory, where boys from the VII class lived, the affected bу dysentery аге 25% and bу CURW - 75%

AN ATTEMPT AT NOSOLOGICAL AND ETIOLOGICAL DIARRHEA SYNDROME DECODING IN PATIENTS WITH PRESUMED ENTERAL INFECTION

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Modification of the ω\omega-Meson Lifetime in Nuclear Matter

The photo production of $\omega$ mesons on the nuclei C, Ca, Nb and Pb has been measured using the Crystal Barrel/TAPS detector at the ELSA tagged photon facility in Bonn. The dependence of the $\omega$ meson cross section on the nuclear mass number has been compared with three different types of models, a Glauber analysis, a BUU analysis of the Giessen theory group and a calculation by the Valencia theory group. In all three cases, the inelastic $\omega$ width is found to be $130-150 \rm{MeV/c^2}$ at normal nuclear matter density for an average 3-momentum of 1.1 GeV/c. In the restframe of the $\omega$ meson, this inelastic $\omega$ width corresponds to a reduction of the $\omega$ lifetime by a factor $\approx 30$. For the first time, the momentum dependent $\omega$N cross section has been extracted from the experiment and is in the range of 70 mb.Comment: 5 pages, 4 figure

In-medium ω\omega mass from the γ+Nb→π0γ+X\gamma + Nb \to \pi^{0}\gamma + X reaction

Data on the photoproduction of $\omega$ mesons on nuclei have been re-analyzed in a search for in-medium modifications. The data were taken with the Crystal Barrel(CB)/TAPS detector system at the ELSA accelerator facility in Bonn. First results from the analysis of the data set were published by D. Trnka et al. in Phys. Rev. Lett 94 (2005) 192303 \cite{david}, claiming a lowering of the $\omega$ mass in the nuclear medium by 14$$ at normal nuclear matter density. The extracted $\omega$ line shape was found to be sensitive to the background subtraction. For this reason a re-analysis of the same data set has been initiated and a new method has been developed to reduce the background and to determine the shape and absolute magnitude of the background directly from the data. Details of the re-analysis and of the background determination are described. The $\omega$ signal on the $Nb$ target, extracted in the re-analysis, does not show a deviation from the corresponding line shape on a $LH_2$ target, measured as reference. The earlier claim of an in-medium mass shift is thus not confirmed. The sensitivity of the $\omega$ line shape to different in-medium modification scenarios is discussed.Comment: 13 pages and 11 figures, submitted for publicatio

K^0 pi^0 Sigma^+ and K^*0 Sigma^+ photoproduction off the proton

The exclusive reactions $\gamma p \to K^{*0} \Sigma^+(1189)$ and $\gamma p \to K^{0} \pi^{0}\Sigma^+(1189)$, leading to the p 4$\pi^{0}$ final state, have been measured with a tagged photon beam for incident energies from threshold up to 2.5 GeV. The experiment has been performed at the tagged photon facility of the ELSA accelerator (Bonn). The Crystal Barrel and TAPS detectors were combined to a photon detector system of almost 4$\pi$ geometrical acceptance. Differential and total cross sections are reported. At energies close to the threshold, a flat angular distribution has been observed for the reaction $\gamma p\to K^{0} \pi^{0}\Sigma^+$ suggesting dominant s-channel production. $\Sigma^*(1385)$ and higher lying hyperon states have been observed. An enhancement in the forward direction in the angular distributions of the reaction $\gamma p \to K^{*0}\Sigma^+$ indicates a $t$-channel exchange contribution to the reaction mechanism. The experimental data are in reasonable agreement with recent theoretical predictions.Comment: 11 pages, 13 figures, submitted to EPJ

Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming

Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs through unknown mechanisms. Comparing human genome binding by these viral transcription factors, we discovered that 25% of binding sites were shared by EBNA 2 and the EBNA 3s and were located predominantly in enhancers. Moreover, 80% of potential EBNA 3A, 3B or 3C target genes were also targeted by EBNA 2, implicating extensive interplay between EBNA 2 and 3 proteins in cellular reprogramming. Investigating shared enhancer sites neighbouring two new targets (WEE1 and CTBP2) we discovered that EBNA 3 proteins repress transcription by modulating enhancer-promoter loop formation to establish repressive chromatin hubs or prevent assembly of active hubs. Re-ChIP analysis revealed that EBNA 2 and 3 proteins do not bind simultaneously at shared sites but compete for binding thereby modulating enhancer-promoter interactions. At an EBNA 3-only intergenic enhancer site between ADAM28 and ADAMDEC1 EBNA 3C was also able to independently direct epigenetic repression of both genes through enhancer-promoter looping. Significantly, studying shared or unique EBNA 3 binding sites at WEE1, CTBP2, ITGAL (LFA-1 alpha chain), BCL2L11 (Bim) and the ADAMs, we also discovered that different sets of EBNA 3 proteins bind regulatory elements in a gene and cell-type specific manner. Binding profiles correlated with the effects of individual EBNA 3 proteins on the expression of these genes, providing a molecular basis for the targeting of different sets of cellular genes by the EBNA 3s. Our results therefore highlight the influence of the genomic and cellular context in determining the specificity of gene deregulation by EBV and provide a paradigm for host-cell reprogramming through modulation of enhancer-promoter interactions by viral transcription factors