Tularemia in the Southeastern Swiss Alps at 1,700 m above sea level.

A 37-year-old man presented with a 4-day history of nonbloody diarrhea, fever, chills, productive cough, vomiting, and more recent sore throat. He worked for the municipality in a village in the Swiss Alps near St. Moritz. Examination showed fever (40 °C), hypotension, tachycardia, tachypnea, decreased oxygen saturation (90 % at room air), and bibasilar crackles and wheezing. Chest radiography and computed tomography scan showed an infiltrate in the left upper lung lobe. He responded to empiric therapy with imipenem for 5 days. After the imipenem was stopped, the bacteriology laboratory reported that 2/2 blood cultures showed growth of Francisella tularensis. He had recurrence of fever and diarrhea. He was treated with ciprofloxacin (500 mg twice daily, oral, for 14 days) and symptoms resolved. Further testing confirmed that the isolate was F. tularensis (subspecies holarctica) belonging to the subclade B.FTNF002-00 (Western European cluster). This case may alert physicians that tularemia may occur in high-altitude regions such as the Swiss Alps

UV slope of z∼\sim3 bright (L>L∗L>L^{*}) Lyman-break galaxies in the COSMOS field

We analyse a unique sample of 517 bright ($L>L^{*}$) LBGs at redshift z$\sim$3 in order to characterise the distribution of their UV slopes $\beta$ and infer their dust extinction under standard assumptions. We exploited multi-band observations over 750 arcmin$^2$ of the COSMOS field that were acquired with three different ground-based facilities: the Large Binocular Camera (LBC) on the Large Binocular Telescope (LBT), the Suprime-Cam on the SUBARU telescope, and the VIRCAM on the VISTA telescope (ULTRAVISTA DR2). Our multi-band photometric catalogue is based on a new method that is designed to maximise the signal-to-noise ratio in the estimate of accurate galaxy colours from images with different point spread functions (PSF). We adopted an improved selection criterion based on deep Y-band data to isolate a sample of galaxies at $z\sim 3$ to minimise selection biases. We measured the UV slopes ($\beta$) of the objects in our sample and then recovered the intrinsic probability density function of $\beta$ values (PDF($\beta$)), taking into account the effect of observational uncertainties through detailed simulations. The galaxies in our sample are characterised by mildly red UV slopes with $\simeq -1.70$ throughout the enitre luminosity range that is probed by our data ($-24\lesssim M_{1600}\lesssim -21$). The resulting dust-corrected star formation rate density (SFRD) is $log(SFRD)\simeq-1.6 M_{\odot}/yr/Mpc^{3}$, corresponding to a contribution of about 25% to the total SFRD at z$\sim$3 under standard assumptions. Ultra-bright LBGs at $z \sim 3$ match the known trends, with UV slopes being redder at decreasing redshifts, and brighter galaxies being more highly dust extinct and more frequently star-forming than fainter galaxies. [abridged]Comment: Matched to journal version. 11 pages, 13 figures, Astronomy & Astrophysics in pres

Cosmological Rescaling through Warped Space

We discuss a scenario where at least part of the homogeneity on a brane world can be directly related to the hierarchy problem through warped space. We study the dynamics of an anti-D3-brane moving toward the infrared cut-off of a warped background. After a region described by the DBI action, the self-energy of the anti-D3-brane will dominate over the background. Then the world-volume scale of the anti-D3-brane is no longer comoving with the background geometry. After it settles down in the infrared end, the world-volume inhomogeneity will appear, to a Poincare observer, to be stretched by an exponentially large ratio. This ratio is close to that of the hierarchy problem between the gravitational and electroweak scales.Comment: 12 pages, 2 figures; v2, PRD version, comments and references adde

On Brane Inflation Potentials and Black Hole Attractors

We propose a new potential in brane inflation theory, which is given by the arctangent of the square of the scalar field. Then we perform an explicit computation for inflationary quantities. This potential has many nice features. In the small field approximation, it reproduces the chaotic and MSSM potentials. It allows one, in the large field approximation, to implement the attractor mechanism for bulk black holes where the geometry on the brane is de Sitter. In particular, we show, up to some assumptions, that the Friedman equation can be reinterpreted as a Schwarzschild black hole attractor equation for its mass parameter.Comment: 12 pages. Reference updated and minor changes added. Version to appear in Int. J. Mod. Phys.

Quasilocalized gravity without asymptotic flatness

We present a toy model of a generic five-dimensional warped geometry in which the 4D graviton is not fully localized on the brane. Studying the tensor sector of metric perturbation around this background, we find that its contribution to the effective gravitational potential is of 4D type (1/r) at the intermediate scales and that at the large scales it becomes 1/r^{1+alpha}, 0<alpha=< 1 being a function of the parameters of the model (alpha=1 corresponds to the asymptotically flat geometry). Large-distance behavior of the potential is therefore not necessarily five-dimensional. Our analysis applies also to the case of quasilocalized massless particles other than graviton.Comment: 9 pages, 1 figure; to be published in Phys. Rev.

Braneworld inflation

We discuss various realizations of the four dimensional braneworld inflation in warped geometries of string theory. In all models the inflaton field is represented by a Dp probe brane scalar specifying its position in the warped throat of the compactification manifold. We study existing inflationary throat local geometries, and construct a new example. The inflationary brane is either a D3- or a D5-brane of type IIB string theory. In the latter case the inflationary brane is wrapping a two-cycle of the compactification manifold. We discuss some phenomenological aspects of the model where slow-roll conditions are under computational control.Comment: 31 pages + 6 figures, v2: published PRD versio

Stability of the Higgs mass in theories with extra dimensions

We analyze the ultraviolet stability of the Higgs mass in recently proposed Kaluza-Klein models compactified on S_1/Z_2 or S_1/(Z_2\times Z_2'), both at the field theory and string theory level. Fayet-Iliopoulos terms of U(1) hypercharge are shown to be of vital importance for this discussion. Models with a single Higgs doublet seem to be generically affected by quadratic divergences.Comment: Contribution to the Proceedings of Durham IPPP meeting May 2001.(12 pages, LaTeX

Comparative phenotypic and functional analyses of the effects of autologous plasma and recombinant human macrophage-colony stimulating factor (M-CSF) on porcine monocyte to macrophage differentiation

Abstract Porcine monocyte-derived macrophages (moMΦ) have been employed as a model cell in numerous studies of the porcine immune system. However, the lack of a standardized method for moMΦ differentiation hampers the comparison of results coming from the use of different laboratory protocols. In this study we compared the use of varying concentrations of autologous plasma (10, 20 and 30% v/v) or recombinant human macrophage-colony stimulating factor (hM-CSF; 50, 100, and 200 ng/ml) to differentiate porcine monocytes into macrophages. Changes in cell morphology and surface marker expression were assessed by confocal microscopy and flow cytometry. Macrophage differentiation was evaluated by analysing TNF-α response to LPS stimulation and determining cytokine secretion patterns under both basal conditions and after classical and alternative activation. The effects of the differentiation methods on metabolic activity and susceptibility to infection with the myelotropic African swine fever virus (ASFV) were also evaluated. Monocytes cultured using the different culture conditions tested augmented in dimension and cellular complexity, but increasing porcine plasma concentrations resulted in a dose dependent enhancement in granularity and a marked pleomorphism. As expected, CD163, MHC class II DR and CD203a expression were up-regulated in both hM-CSF (M-CSF-moMΦ) and autologous plasma cultured macrophages (AP-moMΦ), although a lower percentage of CD163+ cells were found following differentiation with high percentages of porcine plasma. We observed enhanced number of viable cells using high concentration of hM-CSF compared to porcine plasma, suggesting a proliferative effect. Irrespective of differentiation conditions, monocyte differentiation into macrophages resulted in an increased susceptibility to ASFV and yielded larger amounts of LPS-induced TNF-α. AP-moMΦ showed a higher basal release of IL-1RA compared to those cultured with hM-CSF and displayed a reduced ability to respond to classical activation, suggesting that the use of high percentages of porcine plasma led to the acquisition of a M2-like phenotype. We conclude that all the protocols tested in this study can be considered as suitable to produce porcine moMΦ, although the use of hM-CSF provides high responsiveness to M1 polarization. Since a higher phenotypic and functional inter-animal variability was observed in AP-moMΦ, we propose that the use of low concentration of hM-CSF should be adopted as the method of choice to provide a better reproducibility between experiments

Présence du virus de peste équine type 9 en République algérienne. Identification des souches de virus isolées en 1965-1966

Isolement et identification, en 1965-66, de 14 souches de virus de peste équine type 9, au cours de l'épizootie apparue pour la première fois chez les équidés en Algérie à l'automne 1965 dans le sud algérien et qui s'est étendue en 1966 à plusieurs autres régions de la République Algérienn