The role of initial conditions in the ageing of the long-range spherical model

The kinetics of the long-range spherical model evolving from various initial states is studied. In particular, the large-time auto-correlation and -response functions are obtained, for classes of long-range correlated initial states, and for magnetized initial states. The ageing exponents can depend on certain qualitative features of initial states. We explicitly find the conditions for the system to cross over from ageing classes that depend on initial conditions to those that do not.Comment: 15 pages; corrected some typo

Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications

ϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications

Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation

Alzheimer's disease (AD) and type 2 diabetes are connected in a way that is still not completely understood, but insulin resistance has been implicated as a risk factor for developing AD. Here we show an evidence that insulin is capable of reducing cytotoxicity induced by Amyloid-beta peptides (A-beta) in its oligomeric form in a dose-dependent manner. By TUNEL and biochemical assays we demonstrate that the recovery of the cell viability is obtained by inhibition of intrinsic apoptotic program, triggered by A-beta and involving caspase 9 and 3 activation. A protective role of insulin on mitochondrial damage is also shown by using Mito-red vital dye. Furthermore, A-beta activates the stress inducible Hsp70 protein in LAN5 cells and an overexpression is detectable after the addition of insulin, suggesting that this major induction is the necessary condition to activate a cell survival program. Together, these results may provide opportunities for the design of preventive and therapeutic strategies against AD

Ageing in the critical contact process: a Monte Carlo study

The long-time dynamics of the critical contact process which is brought suddenly out of an uncorrelated initial state undergoes ageing in close analogy with quenched magnetic systems. In particular, we show through Monte Carlo simulations in one and two dimensions and through mean-field theory that time-translation invariance is broken and that dynamical scaling holds. We find that the autocorrelation and autoresponse exponents lambda_{Gamma} and lambda_R are equal but, in contrast to systems relaxing to equilibrium, the ageing exponents a and b are distinct. A recent proposal to define a non-equilibrium temperature through the short-time limit of the fluctuation-dissipation ratio is therefore not applicable.Comment: 18 pages, 7 figures, Latex2e with IOP macros; final for

A New Cross-Flow Type Turbine for Ultra-Low Head in Streams and Channels

In the last few decades, hydropower production has been moving toward a new paradigm of low and diffused power density production of energy with small and mini-hydro plants, which usually do not require significant water storage. In the case of nominal power lower than 20 kW and ultra-low head H (H < 5 m), Archimedes screw or Kaplan type turbines are usually chosen due to their efficiency, which is higher than 0.85. A new cross-flow type turbine called Ultra-low Power Recovery System (UL-PRS) is proposed and its geometry and design criteria are validated in a wide range of operating conditions through 2D numerical analysis computed using the ANSYS Fluent solver. The new proposed solution is much simpler than the previously mentioned competitors; its outlet flow has a horizontal direction and attains similar efficiency. The costs of the UL-PRS turbine are compared with the costs of one Kaplan and one cross-flow turbine (CFT) in the case study of the main water treatment plant of the city of Palermo in Italy. In this case, the UL-PRS efficiency is estimated using a URANS 3D numerical analysis computed with the CFX solver

Effect of High Hydrostatic Pressure on the Metabolite Profile of Striped Prawn (Melicertus kerathurus) during Chilled Storage

A variety of metabolites contribute to the freshness and taste characteristics of seafood. This study investigated the effects of high hydrostatic pressure (HHP; 400, 500, and 600 MPa) for 10 min) on the metabolome of striped prawn during chilled storage, in relation to microorganisms’ development. All treated samples showed lower viable counts throughout storage compared to the untreated counterparts. The limit of acceptability from a microbiological point of view was extended from 9 to as many as 35 days by 600 MPa treatment. Metabolites were quantified by 1H-NMR through a targeted-untargeted metabolomic approach. Molecules linked to nucleotides’ degradation and amines’ anabolism suggested an overall freshness improvement granted by HHP. Notably, putrescine and cadaverine were detected only in untreated prawn samples, suggesting the inactivation of degradative enzymes by HHP. The concentration of molecules that influence umami perception was significantly elevated by HHP, while in untreated samples, the concentration of molecules contributing to a sour taste gradually increased during storage. As metabolomics was applied in its untargeted form, it allowed us to follow the overall set of metabolites related to HHP processing and storage, thus providing novel insights into the freshness and taste quality of striped prawn as affected by high hydrostatic pressure

Aging at Criticality in Model C Dynamics

We study the off-equilibrium two-point critical response and correlation functions for the relaxational dynamics with a coupling to a conserved density (Model C) of the O(N) vector model. They are determined in an \epsilon=4-d expansion for vanishing momentum. We briefly discuss their scaling behaviors and the associated scaling forms are determined up to first order in epsilon. The corresponding fluctuation-dissipation ratio has a non trivial large time limit in the aging regime and, up to one-loop order, it is the same as that of the Model A for the physically relevant case N=1. The comparison with predictions of local scale invariance is also discussed.Comment: 13 pages, 1 figur

Critical aging of a ferromagnetic system from a completely ordered state

We adapt the non-linear $\sigma$ model to study the nonequilibrium critical dynamics of O(n) symmetric ferromagnetic system. Using the renormalization group analysis in $d=2+\epsilon$ dimensions we investigate the pure relaxation of the system starting from a completely ordered state. We find that the average magnetization obeys the long-time scaling behavior almost immediately after the system starts to evolve while the correlation and response functions demonstrate scaling behavior which is typical for aging phenomena. The corresponding fluctuation-dissipation ratio is computed to first order in $\epsilon$ and the relation between transverse and longitudinal fluctuations is discussed.Comment: 5 pages, revtex