Analytical and experimental study of two concentric cylinders coupled by a fluid gap

From a structural point of view a liquid coolant type nuclear reactor consists of a heavy steel vessel containing the core and related mechanical components and filled with a hot fluid. This vessel is protected from the severe environment of the core by a shielding structure, the thermal liner, which is usually a relatively thin steel cylinder concentric with the reactor vessel and separated from it by a gap filled with the coolant fluid. This arrangement leads to a potential vibration problem if the fundamental frequency, or one of the higher natural vibration frequencies, of this liner system is close to the frequency of some vibration source present in the reactor vessel. The shell rigidly clamped at its base and free at the top was investigated since it is a better description of the conditions encountered in typical reactor designs

Pittsburgh Radical: Thomas Bell

ABSTRACT TITLE OF PROPOSED PAPER: Pittsburgh Radical: Thomas Bell Author – Richard P. Mulcahy, Ph.D. Thomas Bell (aka Adalbert Thomas Belajčák) is remembered primarily today for his novel Out of this Furnace, which deals with the struggles of a Slovak family in Braddock, PA over the course of three generations. The book culminates with the success of the Steel Workers’ Organizing Committee over U.S. Steel. With this, while Bell’s sympathies are with the SWOC, there does not appear to be anything too radical in terms of what he says in the book. However, when Bell’s record is given a closer examination, some interesting associations come up. First, Bell was a member of the League of American Writers, whose membership included such people as Lillian Hellman, Alvah Bessie, and James Baldwin. This organization was Communist affiliated. Second, Bell gave his support and sponsorship to the Cultural and Scientific Conference for World Peace, which was held at the Waldorf-Astoria Hotel on March 25-27, 1949. This meeting had been sponsored by the National Council of the Arts, Sciences, and Professions, and was denounced as an anti-American/Pro-Soviet jamboree. In addition, not only did Bell give the meeting his support, but he helped to edit its proceedings volume entitled Speaking of Peace. Yet, Bell was never called before any of the Congressional investigating committees of the time as either a suspected Communist or Communist sympathizer. In addition, Bell had a reputation for being a free thinker and a man of integrity. So, we are left with a mystery. Was Bell a Communist sympathizer or fellow-traveler; if not, what was his motive behind his giving his support to such groups. Sadly, there is not much in terms of anything in the record to provide some insights – no correspondence nor memoirs. However, there are a few things that do show up. What this paper seeks to do is try and unravel this mystery based on what is available

The Crusader from Pittsburgh: Michael Musmanno and the Sacco/Vanzetti Case

It is a truism to say that this nation is polarized along ideological lines, with each side retreating into their respective echo chambers, interested only in their version of the truth. Argument ceases in this environment, as each side proclaims its own specific narrative with its own set of facts. While this is unsettling and has been exacerbated by an explosion of media outlets and platforms, this phenomenon is nothing new in our national experience. Other issues have divided America in the past and divided her bitterly. Good cases in point include racial issues, ranging from slavery to civil rights, immigration, and national security, as well as freedom of speech and association. One such case that involved two of these categories was Sacco and Vanzetti: two immigrant Italian anarchists who were arrested, tried, convicted, and eventually executed for a robbery/homicide that took place on the morning of April 15, 1920 in South Braintree, Massachusetts. Part of the Panel: Air Quality and Environmental Justice

Characterization of a Reductively-Activated Elimination Pathway Relevant to the Biological Chemistry of the Kinamycins and Lomaiviticins

The lomaiviticins (1 and 2) and kinamycins (3–5) are bacterial metabolites with potent antimicrobial and antiproliferative activities. Herein we establish that 1–5 are capable of generating electrophilic acylfulvene intermediates (6) under mildly reducing conditions. These acylfulvenes 6 are formed by a multistep process comprising two-electron reduction and loss of dinitrogen to form an ortho-quinone methide, followed by elimination. Based on these studies, the structure of the product formed from 1 in DNA-cleavage assays is proposed (26). We also show that the bis(hydroxynaphthoquinone) substructures of the lomaiviticins activate the metabolites toward reduction. Finally, based on COMPARE and time-dependent cell response profiling analyses, we show that kinamycin C (4) and the monomeric lomaiviticin aglycon (24) operate by a mechanism of action that is distinct from simple diazofluorenes, such as 23

Rumen fluke in Irish sheep: prevalence, risk factors and molecular identification of two paramphistome species

peer-reviewedBackground Rumen flukes are trematode parasites found globally; in tropical and sub-tropical climates, infection can result in paramphistomosis, which can have a deleterious impact on livestock. In Europe, rumen fluke is not regarded as a clinically significant parasite, recently however, the prevalence of rumen fluke has sharply increased and several outbreaks of clinical paramphistomosis have been reported. Gaining a better understanding of rumen fluke transmission and identification of risk factors is crucial to improve the control of this parasitic disease. In this regard, a national prevalence study of rumen fluke infection and an investigation of associated risk factors were conducted in Irish sheep flocks between November 2014 and January 2015. In addition, a molecular identification of the rumen fluke species present in Ireland was carried out using an isolation method of individual eggs from faecal material coupled with a PCR. After the DNA extraction of 54 individual eggs, the nuclear fragment ITS-2 was amplified and sequenced using the same primers. Results An apparent herd prevalence of 77.3 % was determined. Several risk factors were identified including type of pasture grazed, regional variation, and sharing of the paddocks with other livestock species. A novel relationship between the Suffolk breed and higher FEC was reported for the first time. The predominant rumen fluke species found was C. daubneyi. Nevertheless, P. leydeni was unexpectedly identified infecting sheep in Ireland for the first time. Conclusions An exceptionally high prevalence of rumen fluke among Irish sheep flocks has been highlighted in this study and a more thorough investigation is necessary to analyse its economic impact. The isolation of individual eggs coupled with the PCR technique used here has proven a reliable tool for discrimination of Paramphistomum spp. This technique may facilitate forthcoming studies of the effects of paramphistomosis on livestock production. The most noteworthy finding was the identification of P. leydeni affecting sheep in Ireland, however further studies are required to clarify its implications. Also, a significant relationship between Suffolk breed and a heavier infection was found, which can be used as a starting point for future research on control strategies of rumen fluke infection.This study was funded by Irish Department of Agriculture, Food and the Marine research stimulus funding; project reference 13/ S/405

Detained and committed youth: Examining differences in achievement, mental health needs, and special education status

Currently, there is limited research about the relationship between academic, mental health needs, and special education status among populations of incarcerated youth. Additionally, little is known about differences between special education and general education students, or about differences between detained and committed populations. This article reports the results of an investigation of the academic achievement, mental health history, and special education status of 555 detained and incarcerated boys in one mid-Atlantic state. Descriptive data and results from a logistic regression analysis are reported. We found that mean standard scores of participants on standardized achievement tests were one standard deviation below the population mean. We also found high rates of participants with disabilities, and high rates of participants reporting prior therapy and prior use of psychotropic medication. In addition, we found that student academic and mental health characteristics obtained through an intake screening protocol were predictive of special education status, but not of placement in detention or commitment settings. Finally, we found that African American students had a significantly higher risk of being committed than Caucasian students. Implications for future research and practice are discussed

In the Interests of clients or commerce? Legal aid, supply, demand, and 'ethical indeterminacy' in criminal defence work

As a professional, a lawyer's first duty is to serve the client's best interests, before simple monetary gain. In criminal defence work, this duty has been questioned in the debate about the causes of growth in legal aid spending: is it driven by lawyers (suppliers) inducing unnecessary demand for their services or are they merely responding to increased demand? Research reported here found clear evidence of a change in the handling of cases in response to new payment structures, though in ways unexpected by the policy's proponents. The paper develops the concept of 'ethical indeterminacy' as a way of understanding how defence lawyers seek to reconcile the interests of commerce and clients. Ethical indeterminacy suggests that where different courses of action could each be said to benefit the client, the lawyer will tend to advise the client to decide in the lawyer's own interests. Ethical indeterminacy is mediated by a range of competing conceptions of 'quality' and 'need'. The paper goes on to question the very distinction between 'supply' and 'demand' in the provision of legal services

Gastrointestinal nematode control practices on lowland sheep farms in Ireland with reference to selection for anthelmintic resistance

Gastrointestinal parasitism is a widely recognised problem in sheep production, particularly for lambs. While anthelmintics have a pivotal role in controlling the effects of parasites, there is a paucity of data on how farmers use anthelmintics. A representative sample of Irish lowland farmers were surveyed regarding their parasite control practices and risk factors that may contribute to the development of anthelmintic resistance. Questionnaires were distributed to 166 lowland Irish sheep producers. The vast majority of respondents treated their sheep with anthelmintics. Lambs were the cohort treated most frequently, the majority of farmers followed a set programme as opposed to treating at sign of disease. A substantial proportion (61%) administered four or more treatments to lambs in a 'normal' year. Departures from best practice in anthelmintic administration that would encourage the development of anthelmintic resistance were observed. In conclusion, in the light of anthelmintic resistance, there is a need for a greater awareness of the principles that underpin the sustainable use of anthelmintics and practices that preserve anthelmintic efficacy should be given a very high priority in the design of helminth control programmes on each farm. To this end, given that veterinary practitioners and agricultural advisors were considered to be the farmer's most popular information resource, the capacity of these professions to communicate information relating to best practice in parasite control should be targeted