Drug-induced dermatomyositis after lacosamide: A case report.

Here we describe a caseof a woman who had DM after treatment withlacosamide. To our knowledge, drug-induced DMfrom lacosamide has not been reported previously

Spin-chain model of a many-body quantum battery

Recently, it has been shown that energy can be deposited on a collection of quantum systems at a rate that scales super-extensively. Some of these schemes for `quantum batteries' rely on the use of global many-body interactions that take the batteries through a correlated short cut in state space. Here, we extend the notion of a quantum battery from a collection of a priori isolated systems to a many-body quantum system with intrinsic interactions. Specifically, we consider a one-dimensional spin chain with physically realistic two-body interactions. We find that the spin-spin interactions can yield an advantage in charging power over the non-interacting case, and we demonstrate that this advantage can grow super-extensively when the interactions are long ranged. However, we show that, unlike in previous work, this advantage is a mean-field interaction effect that does not involve correlations and that relies on the interactions being intrinsic to the battery.Comment: 9 pages, 6 figure

GPS based Multi-hop Communication with Localization in Subterranean Wireless Sensor Networks

AbstractOur research work proposes Multi-hop Communication with Localization (MCL), a strategy to localize and route information to nodes present in such areas by determining angles and distances of consecutive nodes hop by hop towards the Base Station. Based on the application area, Subterranean Wireless Sensor Networks are specifically designed to detect underground abnormal conditions and reported to the base station. Many protocols use distance between the nodes as one of the criteria for multi-hop communication in the network. It is found to be necessary to know the location of the nodes and the distance between the nodes in many power optimization protocols. But the query of how to attain the distance or the location arises in the same. The main objective here is to design a technique to both localize and transmit data efficiently in subterranean areas. Initially there is a group of nodes deployed in the underground areas all of which bond to a sink that is further connected to the Base Station. It is possible to locate all the nodes through GPS which can be used as a reference in the worst case scenario by the Base Station. The sink node has a Node Transmission Area (NTA) within which a node can be directly recognized by the sink node otherwise it finds the target node through the intermediate nodes. Our empirical work proves the computational method on attaining the performance

Cellular and circuit mechanisms underlying spinocerebellar ataxias

Degenerative ataxias are a common form of neurodegenerative disease that affect about 20 individuals per 100,000. The autosomal dominant spinocerebellar ataxias (SCAs) are caused by a variety of protein coding mutations (single nucleotide changes, deletions and expansions) in single genes. Affected genes encode plasma membrane and intracellular ion channels, membrane receptors, protein kinases, protein phosphatases and proteins of unknown function. Although SCA-linked genes are quite diverse they share two key features: first, they are highly, although not exclusively, expressed in cerebellar Purkinje neurons (PNs), and second, when mutated they lead ultimately to the degeneration of PNs. In this review we summarize ataxia-related changes in PN neurophysiology that have been observed in various mouse knockout lines and in transgenic models of human SCA. We also highlight emerging evidence that altered metabotropic glutamate receptor signalling and disrupted calcium homeostasis in PNs form a common, early pathophysiological mechanism in SCAs. Together these findings indicate that aberrant calcium signalling and profound changes in PN neurophysiology precede PN cell loss and are likely to lead to cerebellar circuit dysfunction that explains behavioural signs of ataxia characteristic of the disease

A Survey Paper of Optical Fiber Sensor

As the technology changes use of instruments and accuracy also increases. Besides the advantages of fiber optic sensor, t he cost is reduces and evaluation will be increase day by day. Fiber optic sensor are used in place of electrical sensor and used along with optoelectronics devices. This paper covers different types of fiber optic sensors their application and their practically simulated results

A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2

Metabotropic glutamate receptor 1 (mGluR1) function in Purkinje neurons (PNs) is essential for cerebellar development and for motor learning and altered mGluR1 signaling causes ataxia. Downstream of mGluR1, dysregulation of calcium homeostasis has been hypothesized as a key pathological event in genetic forms of ataxia but the underlying mechanisms remain unclear. We find in a spinocerebellar ataxia type 2 (SCA2) mouse model that calcium homeostasis in PNs is disturbed across a broad range of physiological conditions. At parallel fiber synapses, mGluR1-mediated excitatory postsynaptic currents (EPSCs) and associated calcium transients are increased and prolonged in SCA2 PNs. In SCA2 PNs, enhanced mGluR1 function is prevented by buffering [Ca 2+ ] at normal resting levels while in wildtype PNs mGluR1 EPSCs are enhanced by elevated [Ca 2+ ]. These findings demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a mechanism likely to contribute to PN dysfunction and loss in SCA2

Pressure Raman effects and internal stress in network glasses

Raman scattering from binary GexSe1-x glasses under hydrostatic pressure shows onset of a steady increase in the frequency of modes of corner-sharing GeSe4 tetrahedral units when the external pressure P exceeds a threshold value Pc. The threshold pressure Pc(x) decreases with x in the 0.15 < x < 0.20 range, nearly vanishes in the 0.20 < x < 0.25 range, and then increases in the 0.25 < x < 1/3 range. These Pc(x) trends closely track those in the non-reversing enthalpy, DHnr(x), near glass transitions (Tgs), and in particular, both DHnr(x) and Pc(x) vanish in the reversibility window (0.20 < x < 0.25). It is suggested that Pc provides a measure of stress at the Raman active units; and its vanishing in the reversibility window suggests that these units are part of an isostatically rigid backbone. Isostaticity also accounts for the non-aging behavior of glasses observed in the reversibility window