Ultrafine particles: A review about their health effects, presence, generation, and measurement in indoor environments

Human exposure to aerosols has been associated with diseases and death, reducing the population's life expectancy up to a few years. Indoor particulate matter is predominant in determining human exposure to PM because people spend most of their time indoors. Ultrafine particles (UFP) impact the human body differently from PM2.5 or PM10 fractions. Therefore, scientists cannot apply the same approach to assess the effects of UFP and PM on human health. This work summarizes the health effects, generation, and measurement of ultrafine particles in indoor environments through a literature review. When indoor particle generation is low, particle concentration indoors depends strongly on outdoor aerosols, with an indoor-to-outdoor ratio below 1. In buildings with a high indoor particle generation, the average indoor-to-outdoor UFP concentration ratio can reach 14. Combustion, electric heating, and house cleaning are the main generators of UFP indoors. Current standards for UFP assessments do not provide a solid ground for accurate and reliable measurements. Moreover, the lowest detection limit of instruments used to measure UFP concentration can be significantly different while also showing poor repeatability even among instruments with the same manufacturer and model. Consequently, data supplied by studies on UFP health effects are insufficient and inconclusive. Using ultrafine portable monitors would allow determining properly human exposure to PM0.1, but such instruments are expensive for wide use. Since there is a good correlation between UFP and NOX data, low-cost NOX sensors are good candidates to create a dense and accurate monitoring network of UFP, including indoor environments

Two-dimensional numerical simulation of saltating particles using granular kinetic theory

Most granular flows at environmental conditions are unsteady and exhibit a complex physical behavior. Dune formation and migration in the desert are controlled not only by the flow of saltating particles over the sand bed, but also by turbulent atmospheric airflow. In fact, sediments are transported by the atmospheric airflow within a thin layer only a few centimeters above the sandy surface. These jumping particles reach a maximum sediment mass flux level at a certain delay time (known as the “saturation time”) after the initial movement by sliding and rolling begins. Unlike sediment transport in water where the particles are lifted by the turbulent suspension, the saltating particles are kept alive in the layer mainly due to particle-particle and particle-bed collisions. In order to model this Aeolian transport of sand, Jenkins and Pasini [1] proposed a two-fluid model (one-dimensional and steady state) using Granular Kinetic Theory (GKT) to describe the solid-phase stress. The present work extends the original idea of Jenkins and Pasini [1] by using a more robust model of GKT for the kinetic/collisional contributions to the solid-phase stress tensor, together with a friction model activated for sustained contacts between particles. In addition, a standard k-ε turbulence model for the air and a drag model for the interaction between the phases are employed. A rectangular 2D geometry was chosen with a logarithmic profile for the inlet air velocity, along with an initial amount of sand at rest in the lower part of the simulation domain, resembling the particle saltating flow commonly seen in the vertical middle plane within saltation wind tunnels. This model is validated with experimental data from Liu and Dong [2] and the results given by Pasini and Jenkins [1]. A good estimation for the particle erosion and mass flux in the saltation layer is predicted, even though the profiles of mass flux and concentration within the transport layer are very thin and lowe

Two-dimensional numerical simulation of saltating particles using granular kinetic theory

Most granular flows at environmental conditions are unsteady and exhibit a complex physical behavior. Dune formation and migration in the desert are controlled not only by the flow of saltating particles over the sand bed, but also by turbulent atmospheric airflow. In fact, sediments are transported by the atmospheric airflow within a thin layer only a few centimeters above the sandy surface. These jumping particles reach a maximum sediment mass flux level at a certain delay time (known as the “saturation time”) after the initial movement by sliding and rolling begins. Unlike sediment transport in water where the particles are lifted by the turbulent suspension, the saltating particles are kept alive in the layer mainly due to particle-particle and particle-bed collisions. In order to model this Aeolian transport of sand, Jenkins and Pasini [1] proposed a two-fluid model (one-dimensional and steady state) using Granular Kinetic Theory (GKT) to describe the solid-phase stress. The present work extends the original idea of Jenkins and Pasini [1] by using a more robust model of GKT for the kinetic/collisional contributions to the solid-phase stress tensor, together with a friction model activated for sustained contacts between particles. In addition, a standard k-ε turbulence model for the air and a drag model for the interaction between the phases are employed. A rectangular 2D geometry was chosen with a logarithmic profile for the inlet air velocity, along with an initial amount of sand at rest in the lower part of the simulation domain, resembling the particle saltating flow commonly seen in the vertical middle plane within saltation wind tunnels. This model is validated with experimental data from Liu and Dong [2] and the results given by Pasini and Jenkins [1]. A good estimation for the particle erosion and mass flux in the saltation layer is predicted, even though the profiles of mass flux and concentration within the transport layer are very thin and lowe

Corpos estranhos retirados durante a cirurgia e a necropsia em um equino

O artigo não apresenta resumo

Characterization of Staphylococcus spp. strains in milk from buffaloes with mastitis in Brazil: the need to identify to species level to avoid misidentification.

ABSTRACT - Mastitis is an inflammation of the mammary gland that affects dairy cattle worldwide causing economic losses. Coagulase-negative staphylococci (CNS) are the predominant cause of this type of infection. We have recently showed that coagulase-positive staphylococci could be misidentified. So, the aim of this study was to characterize the Staphylococcus spp. strains initially classified as coagulase-negative Staphylococci, isolated from buffalo with subclinical mastitis. Milk of buffaloes with mastitis in herds was collected and 9 strains were identified as CNS by phenotypic tests. Molecular methodologies latter identified the strains as coagulase-negative Staphylococcus chromogenes (5), coagulase-positive Staphylococcus hyicus (2) and coagulase-positive Staphylococcus aureus (2). Our results strongly support the need to identify the isolates to a species level in order to avoid misidentification and to be aware of the classification using the coagulase test alone. RESUMO - A mastite é uma inflamação da glândula mamária que afeta o gado leiteiro em todo o mundo, causando perdas econômicas. Staphylococcus coagulase-negativa (SCN) são a causa predominante desse tipo de infecção. Mostrou-se recentemente que Staphylococcus coagulase-positiva podem ser identificados erroneamente. Assim, o objetivo deste estudo foi caracterizar cepas de Staphylococcus spp. inicialmente classificados como Staphylococcus coagulase-negativa, isolados de búfalas com mastite subclínica. O leite de búfalas com mastite foi coletado, e nove cepas foram identificadas como SCN por testes fenotípicos. Metodologias moleculares identificaram as cepas como Staphylococcus chromogenes coagulase-negativa (5) Staphylococcus hyicus coagulase-positiva (2) e Staphylococcus aureus coagulase-positiva (2). Os resultados reforçam a necessidade de identificar as cepas em termos de espécie, a fim de se evitarem erros de identificação e estar atento à classificação utilizando o teste de coagulase sozinho

Redução de fratura de rádio e ulna em bezerro neonato utilizando-se de placa óssea de neutralização associada a imobilização externa com gesso e muleta de thomas modificada

O artigo não apresenta resumo

Pneumatic wound compression after hip fracture surgery did not reduce postoperative blood transfusion: A randomized controlled trial involving 292 fractures

Background and purpose Patients with fracture of the proximal femur often undergo blood transfusion. A pneumatic compression bandage has been shown to reduce transfusion after primary hip arthroplasty for osteoarthritis. In this randomized trial, we evaluated the efficacy of this bandage following surgery for hip fracture

A Mitosis Block Links Active Cell Cycle with Human Epidermal Differentiation and Results in Endoreplication

How human self-renewal tissues co-ordinate proliferation with differentiation is unclear. Human epidermis undergoes continuous cell growth and differentiation and is permanently exposed to mutagenic hazard. Keratinocytes are thought to arrest cell growth and cell cycle prior to terminal differentiation. However, a growing body of evidence does not satisfy this model. For instance, it does not explain how skin maintains tissue structure in hyperproliferative benign lesions. We have developed and applied novel cell cycle techniques to human skin in situ and determined the dynamics of key cell cycle regulators of DNA replication or mitosis, such as cyclins E, A and B, or members of the anaphase promoting complex pathway: cdc14A, Ndc80/Hec1 and Aurora kinase B. The results show that actively cycling keratinocytes initiate terminal differentiation, arrest in mitosis, continue DNA replication in a special G2/M state, and become polyploid by mitotic slippage. They unambiguously demonstrate that cell cycle progression coexists with terminal differentiation, thus explaining how differentiating cells increase in size. Epidermal differentiating cells arrest in mitosis and a genotoxic-induced mitosis block rapidly pushes epidermal basal cells into differentiation and polyploidy. These observations unravel a novel mitosis-differentiation link that provides new insight into skin homeostasis and cancer. It might constitute a self-defence mechanism against oncogenic alterations such as Myc deregulation