Effectiveness of aerobic exercises and resistance exercises on blood pressure in stage I hypertension patients: A Comparative study

INTRODUCTION: Hypertension is when mean arterial pressure is greater than the upper range of the accepted normal measure. A mean arterial pressure greater than 110 mm Hg (normal is about 90 mm Hg) is considered to be hypertensive. This level of mean pressure occurs when the diastolic blood pressure is greater than 90 mm Hg and the systolic pressure is greater than about 135 mm Hg. In severe hypertension, the mean arterial pressure can rise up to 150 to 170 mm Hg, with diastolic pressure as high as 130 mm Hg and systolic pressure occasionally as high as 250 mm Hg. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC-VII report) has recommended a new classification for adults – 18 years or older. OBJECTIVE: It is an experimental study design to determine the effectiveness of aerobic exercises and resistance exercises on blood pressure in stage I hyper tension patients. PARTICIPANTS: A sample of 40 stage I hyper tension patients were divided in to 2 groups: Group A: Experimental group: Treated with aerobic and resistance exercises. Group B: Control Group: Treated with resistance exercises. OUTCOME Measures: Systolic blood pressure and diastolic blood pressure- measures by sphygmomanometer. RESULTS: Statistically group A was significant when compared to group B received normal blood pressure. CONCLUSION: The study concludes aerobic and resistance exercises in patients with stage I hypertension. Thus, this study accepts the alternate hypothesis and rejects the null hypothesis

Outcome Analysis of Arthroscopic Reconstruction of Anterior Cruciate Ligament in Adults

BACKGROUND: Anterior cruciate ligament injury is the common knee injury consequent to contact sports. There are different techniques recommended for the ACL reconstruction, with different graft materials. The aim of this study is to evaluate the functional outcome of arthroscopic single bundle ACL reconstruction using hamstring tendon graft in ACL deficient knees in adults. METHODOLOGY: Between 2014 to 2017 a prospective study was conducted in Thanjavur Medical College on 21 ACL deficient patients (M =19, F = 2] .All patients were evaluated pre-operatively using the Lysholm & Gillquist score and IKDC – 2000 score. All patients underwent arthroscopic single bundle ACL reconstruction with hamstring tendon graft , which was fixed with an endo-button CL fixation system on the femoral side and an interference screw on tibial side. They were advised a regular rehabilitation protocol. All patients were evaluated post-operatively at 6 weeks, 3 months, 6 months and a year by same assessment scores. RESULTS: 20 patients were available for follow up for a period of 6 months to 2 years. The mean follow-up period was 10.5 months. When compared with their respective pre-operative knee assessment scores, it was found that a definite improvement was there in their knee function. The results were good to excellent in 80% patients, fair in 10 % and poor in 10 % cases. CONCLUSION: For young active adults, single bundle reconstruction by arthroscopic methods gives acceptable results. The problems which are faced post-operatively can be again settled arthroscopically. A long term follow-up of these cases is a must to analyze if there is degeneration that happened in the time between injury and ligament reconstruction

Effect of organic and inorganic fertilizer on phytochemical constituents in sunflower

The present study was conducted to characterize the effect of organic and inorganic fertilizer on the phytochemical constituents of sun flower. The phytochemical constituent such as chlorophyll a, chlorophyll b, total chlorophyll and carotenoid content were analyzed. From the result it was observed that both the treatments had significantly improved the phytochemical constituents of sunflower. Among the treatments, organic fertilizer is found to be more efficient than inorganic fertilizer over control. The present work indicates towards the beneficial effect or organic and inorganic fertilizers for the improvement of sunflower

DESIGN OF ONCHIP LOW DROPOUT (LDO) REGULATOR FOR POWER MANAGEMENT APPLICATION

A low dropout regulator is proposed in this paper. The regulator is designed with classic five pack model to decrease the number of devices and make the design compact and also reduce the power consumption. The system is designed and simulated in cadence virtuoso environment under 180nm technology node. Three models of LDO is proposed in this paper, with all having same error amplifier but with small variations. The advantages and disadvantages of each model will be discussed in the paper. The LDOs have linear characteristic over a good input range. It has good transient response to load variation.Â

siRNA knockdown of SPHK1 in vivo protects mice from systemic, type-I Allergy.

Systemic anaphylaxis is considered to be a typical immediate hypersensitivity response, determined by the activation of immune cells,
via antigen-induced aggregation of IgE-sensitized FcεRI cells. Perhaps most the important cells, in the immediate hypersensitivity responses, are mast cells. We have previously shown that SPHK1 plays a key role in the intracellular signaling pathways triggered by FceRI aggregation on human
mast cells. More recently, we performed a genome-wide gene expression profiling of human mast cells, sensitized with IgE alone, or stimulated by FcεRI aggregation. We found that sphingosine kinase 1 (SPHK1) was one
of genes activated at the earlier stages of mast cell activation, including during sensitization. Moreover, SPHK1 has been shown, by us and others, to be a key player in the intracellular signaling pathways triggered by
several immune-receptors, including fMLP, C5a, and Fcg- and Fcereceptors. Here we have investigated the in vivo role of SPHK1 in allergy, using a specific siRNA to knockdown SPHK1 in vivo. Our results support a role for
SPHK1 in the inflammatory responses that share clinical, immunological, and histological features of type I hypersensitivity. Thus, mice pretreated with the siRNA for SPHK1 were protected from the IgE mediated allergic
reactions including: temperature changes, histamine release, cytokine production, cell-adhesion molecule expression, and immune cell infiltration into the lungs

NANOEMULSIONS FOR PROSTRATE CANCER THERAPY: AN OVERVIEW

The objective of this review is to focus the inferences of low/poor bioavailability and lack of dose proportionality for the oral delivery of drugs in prostatecancer therapy. To overcome such problems, various formulation strategies has been reported including various methods for the use of surfactants,cyclodextrins, solid dispersions, micronization, permeation enhancers, and lipids. Flutamide is an antiandrogen drug and used for the therapy of prostate cancer. The flutamide drug is having limited clinical application due to its poor water solubility and needs enhancement of its dissolution rate in simulated gastric fluids. The lipid-based formulations such as nanoemulsion have been shown to improve the solubility and oral absorption of lipophilic drugs. To conclude, this article emphasizes the various approaches of nanoemulsion based formulation for prostate cancer therapy.Â

A study on functional and radiological outcome of complex tibial plateau fractures by posteromedial plating

Background: In orthopaedic practice, three column concept and fixation for proximal tibia are becoming popular as it was proved that fixation of posterior column is a must for proper weight transmission and stability. This study demonstrates the use of the posteromedial surgical approach to the knee in treating patients with complex tibial plateau injuries with a posteromedial column fracture. The aim of the study was to study the functional and radiological outcome of complex tibial plateau fracture by posteromedial plating.Methods: This is a prospective study involving 20 patients with complex tibial condyle fractures with posterior column fractures. Preoperative computed tomography is taken with radiography for complete evaluation of fracture fragments even in the coronal plane. Fractures were classified as Schatzker type 4 or above with a posteromedial split depression. Plating is done with posteromedial locking compression for buttressing posteromedial fragment. The outcome of surgery was evaluated using the Oxford knee scoring system. Longest follow up of study is 2 years.Results: All fractures healed within 6 months without any secondary displacements or secondary osteoarthritis. Out of 20 patients 16 patients have the postoperative anatomic reduction (0 mm step off) 2 had an acceptable reduction of <2 mm step off. At 4-12 months median range of flexion 135*(125-145*). The mean Oxford knee score was 25-33.Conclusions: Fixation of posteromedial fragment in a complex tibial condyle fracture is a must as it involves posterior column. Using a locking compression plate provides perfect fracture fixation and thereby more stability to knee joint & better functional outcome