53 research outputs found
Validation of an algorithm to reveal the U wave in atrial fibrillation
Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U wave measurement algorithm for AF patients. Multi-beat averaging was applied to ECGs of 25 patients during paroxysms of AF and the presence of U waves compared to those from the same patients during sinus rhythm (SR). In a further database of 10 long-term AF recordings, the number of beats for effective U wave extraction by the algorithm was calculated. U waves were revealed in all AF recordings and there was no significant difference between the presence of U waves in AF and SR (p = 0.88). U wave amplitude was significantly increased in AF (mean (s.d.) amplitude 55 (39) AF vs 37 (28) μV SR, p = 0.005). The presence of U waves could easily be discerned when as few as 10 beats were used in the algorithm. The study demonstrates the validity of the algorithm to reveal U waves in AF recordings. The algorithm offers the potential to detect U wave abnormalities in patients with AF
Reliability Analysis of The Estimated Parameters in Groundwater Systems
Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv
Isolation, characterisation and in vitro screening of anticataract potential of Fucoidan from Sargassum wightii Greville
Introduction: The present study was designed to isolate Fucoidan from Sargassum wightii Greville and to evaluate its in-vitro anti cataract potential against galactose induced cataract in isolated goat lenses.
Methods: Fucoidan was isolated from S. wightii Greville and its sulfate content was estimated through barium chloride method. Isolated goat lenses were divided into 5 groups as group-I (normal control- vehicle treated), group-II (disease control- galactose treated 55 mM), group-III (galactose 55 mM + standard-ascorbic acid 20 μg/mL), group-IV (galactose 55 mM + Fucoidan-20 μg/mL) and group-V (galactose 55 mM + Fucoidan 40 μg/mL) and incubated for 72 hours, respectively, and subjected to biochemical estimations. The opacity of lenses was also noted prior to biochemical estimation.
Results: The percentage yield of isolated Fucoidan was found to be 0.65%. The extent of sulfation in the isolated Fucoidan was found to be as high as 33%. In high-performance thin-layer chromatography (HPTLC) studies, Peak 3 with Rf value of 0.18 matched with the standard D-glucose Rf value. Galactose induced cataractous lenses showed significant oxidative stress when compared to normal lenses whereas treatment with Fucoidan 20 and 40 μg/mL significantly combated oxidative stress and prevented the development of cataract when compared to cataractous lenses. The results obtained with the treatment of Fucoidan were dose dependant and comparable to standard.
Conclusion: The present study substantiates the claim of anti-cataract potential of Fucoidan, which may be correlated to its anti-oxidant property
Thin Domain Walls in Lyra Geometry
This paper studies thin domain walls within the frame work of Lyra Geometry.
We have considered two models. First one is the thin domain wall with
negligible pressures perpendicular and transverse direction to the wall and
secondly, we take a particular type of thin domain wall where the pressure in
the perpendicular direction is negligible but transverse pressures are existed.
It is shown that the thin domain walls have no particle horizon and the
gravitational force due to them is attractive.Comment: 8 pages, typos are corrected, published Astrophysics and Space
Sciences 305, 337 (2006
Molecular mapping of dry root rot resistance genes in chickpea (Cicer arietinum L.)
Dry root rot (DRR) caused by Rhizoctonia
bataticola [(Taub.) Butler] is an emerging disease of
chickpea (Cicer arietinum L.) and a serious constraint
to chickpea production in warm and arid regions. To
identify the genomic regions conferring resistance to
DRR, a total of 182 F9 derived Recombinant Inbred
Lines (RILs) were developed from the cross between a
susceptible line BG 212 and moderately resistant
breeding line ICCV 08305. The parental lines and
RILs were screened against Rb 6 isolate of R.
bataticola using paper towel method under controlled environment at ICRISAT during 2016 and 2017. The
RILs were genotyped with cost-effective SNP genotyping
platform, Affymetrix Axiom CicerSNP
array. As a result, a high-density genetic map with
13,110 SNP markers spanning 1224.11 cM with an
average inter marker distance of 0.09 cM was developed.
A single minor QTL (‘qDRR-8’) explaining
6.70% PVE with LOD scores 3.34 was identified on
CaLG08 for DRR resistance which could be further
explored for mining candidate genes and the linked
SNP markers could be further validated for application
in marker-assisted selection of DRR resistance in
chickpea breeding programs
Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of manifestations, including steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte accumulation in the form of steatohepatitis. The adhesion molecule vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase that promotes leukocyte recruitment to the liver, and the soluble form (sVAP-1) accounts for most circulating monoamine oxidase activity, has insulin-like effects, and can initiate oxidative stress. Here, we determined that hepatic VAP-1 expression is increased in patients with chronic liver disease and that serum sVAP-1 levels are elevated in patients with NAFLD compared with those in control individuals. In 4 murine hepatic injury models, an absence or blockade of functional VAP-1 reduced inflammatory cell recruitment to the liver and attenuated fibrosis. Moreover, disease was reduced in animals expressing a catalytically inactive form of VAP-1, implicating enzyme activity in the disease pathogenesis. Within the liver, hepatic stromal cells expressed functional VAP-1, and evaluation of cultured cells revealed that sVAP-1 promotes leukocyte migration through catalytic generation of ROS, which depended on VAP-1 enzyme activity. VAP-1 enhanced stromal cell spreading and wound closure and modulated expression of profibrotic genes. Together, these results link the amine oxidase activity of VAP-1 with hepatic inflammation and fibrosis and suggest that targeting VAP-1 has therapeutic potential for NAFLD and other chronic fibrotic liver diseases
Switched-capacitor power-converter topology overview and performance comparison
Switched-capacitor power converters are interesting candidates to realize integrated power converters with acceptable power efficiencies. Depending on the input and output voltage ranges to be accommodated at a desired efficiency, certain voltage conversion ratio(s) need(s) to be implemented. Though the theoretical minimum number of floating capacitors to realize a desired voltage conversion ratio is known, how to actually synthesize the corresponding topologies and what impact these topologies have on circuit performance is less trivial. Besides two-clock-phase topologies, multiple-clock-phase topologies have recently been introduced. This paper gives an overview of various methods to implement desired voltage conversion ratios with two or multiple clock phases and compares their performance under given boundary conditions
Isolation, characterisation and in vitro screening of anticataract potential of Fucoidan from Sargassum wightii Greville
Introduction: The present study was designed to isolate Fucoidan from Sargassum wightii Greville and to evaluate its in-vitro anti cataract potential against galactose induced cataract in isolated goat lenses. Methods: Fucoidan was isolated from S. wightii Greville and its sulfate content was estimated through barium chloride method. Isolated goat lenses were divided into 5 groups as group-I (normal control- vehicle treated), group-II (disease control- galactose treated 55 mM), group-III (galactose 55 mM + standard-ascorbic acid 20 μg/mL), group-IV (galactose 55 mM + Fucoidan-20 μg/mL) and group-V (galactose 55 mM + Fucoidan 40 μg/mL) and incubated for 72 hours, respectively, and subjected to biochemical estimations. The opacity of lenses was also noted prior to biochemical estimation. Results: The percentage yield of isolated Fucoidan was found to be 0.65%. The extent of sulfation in the isolated Fucoidan was found to be as high as 33%. In high-performance thin-layer chromatography (HPTLC) studies, Peak 3 with Rf value of 0.18 matched with the standard D-glucose Rf value. Galactose induced cataractous lenses showed significant oxidative stress when compared to normal lenses whereas treatment with Fucoidan 20 and 40 μg/mL significantly combated oxidative stress and prevented the development of cataract when compared to cataractous lenses. The results obtained with the treatment of Fucoidan were dose dependant and comparable to standard. Conclusion: The present study substantiates the claim of anti-cataract potential of Fucoidan, which may be correlated to its anti-oxidant property
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