Nanofluid Flow over a Permeable Surface with Convective Boundary Conditions and Radiative Heat Transfer

We investigate the effects of thermal radiation and convective boundary conditions on heat and mass transfer in nanofluid flow over a permeable flat plate. The mathematical model for the nanofluid incorporates variations in the nanoparticle volume fraction of up to 20%. The performance of two water-based nanofluids, namely, stable suspensions of copper and gold nanoparticles in water was investigated. The governing partial differential equations were transformed into ordinary ones using a similarity transformation and solved numerically. The numerical results were validated by comparison with previously published results in the literature. The main focus of this paper is to study the fluid and surface parameters such as the radiation parameter, and suction/injection parameter, solute concentration profiles, as well as the skin friction coefficient and heat and mass transfer rates were conducted

Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms

Multidrug resistance mediated by P-glycoprotein in cancer cells has been a major issue that cripples the efficacy of chemotherapy agents. Aimed for improved efficacy against resistant cancer cells, we designed and synthesized 25 oxindole derivatives based on indirubin by structure-activity relationship analysis. The most potent one was named PH II-7, which was effective against 18 cancer cell lines and 5 resistant cell lines in MTT assay. It also significantly inhibited the resistant xenograft tumor growth in mouse model. In cell cycle assay and apoptosis assay conducted with flow cytometry, PH II-7 induced S phase cell cycle arrest and apoptosis even in resistant cells. Consistently revealed by real-time PCR, it modulates the expression of genes related to the cell cycle and apoptosis in these cells, which may contributes to its efficacy against them. By side-chain modification and FITC-labeling of PH II-7, we were able to show with confocal microscopy that not only it was not pumped by P-glycoprotein, it also attenuated the efflux of Adriamycin by P-glycoprotein in MDR tumor cells. Real-time PCR and western blot analysis showed that PH II-7 down-regulated MDR1 gene via protein kinase C alpha (PKCA) pathway, with c-FOS and c-JUN as possible mediators. Taken together, PH II-7 is a dual-functional compound that features both the cytotoxicity against cancer cells and the inhibitory effect on P-gp mediated drug efflux

Entropy analysis on convective film flow of power-law fluid with nanoparticles along an inclined plate

Entropy generation in a two-dimensional steady laminar thin film convection flow of a non-Newtonian nanofluid (Ostwald-de-Waele-type power-law fluid with embedded nanoparticles) along an inclined plate is examined theoretically. A revised Buongiorno model is adopted for nanoscale effects, which includes the effects of the Brownian motion and thermophoresis. The nanofluid particle fraction on the boundary is passively rather than actively controlled. A convective boundary condition is employed. The local nonsimilarity method is used to solve the dimensionless nonlinear system of governing equations. Validation with earlier published results is included. A decrease in entropy generation is induced due to fluid friction associated with an increasing value of the rheological power-law index. The Brownian motion of nanoparticles enhances thermal convection via the enhanced transport of heat in microconvection surrounding individual nanoparticles. A higher convective parameter implies more intense convective heating of the plate, which increases the temperature gradient. An increase in the thermophoresis parameter decreases the nanoparticle volume fraction near the wall and increases it further from the wall. Entropy generation is also reduced with enhancement of the thermophoresis effect throughout the boundary layer