Synthesis and antimicrobial activity of 4, 5-dihydropyrazoline derivatives

In search of new potential antimicrobial agents, series of trisubstituted 4.5-dihydropyrazoline derivatives have been synthesized starting from chalcones. A mixture of 4-phenylbut-3-en-2-one (1, 0.001mmol), phenyl hydrazine hydrochloride (2a-g 0.001mmol) and sodium acetate (0.002mmol) in ethyl alcohol was stirred at room temperature for 1 hr to get trisubstituted 4,5-dihydropyrazoles (3a-g) in good yield. Spectral, X-ray diffraction and elemental analysis confirmed the structures of the products. The synthesised compounds have been evaluated in vitro for their antimicrobial activity. The results revealed that some compounds particularly with chloro substituents act as potential antimicrobial agents

Pyrazoles: Synthetic strategies and their pharmaceutical applications-an overview

Pyrazoles are an important class of five membered heterocyclic compounds; are widely found as the core structure in a large variety of compounds that possess important agrochemical and pharmaceutical activities. Pyrazoles have been the recent target of numerous methodologies, mostly due to their prevalence as scaffolds in synthesis of bioactive compounds and reactions in different media. The aim of this review is to provide an up to date developments in the synthetic strategies, biological activities associated with pyrazole derivatives. Different synthetic methodologies and the diverse pharmacological activities of pyrazole moiety was discussed

Evaluation and studies on the structural impact of 3-Aryl-5-(4-Methoxyphenyl)-4,5-Dihydroisoxazole-4-Carbonitriles on their biological activities

In present study, a series of isoxazole derivatives was synthesized and evaluated for antibacterial and antifungal activities by disc diffusion method using different bacterial and fungal strains. Some compounds of the series exhibited promising antibacterial and antifungal activity compared to standard drugs. The minimum inhibitory concentration (MIC’s) was determined against each organism. The compounds were tested for their antioxidant activity and reducing power ability. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of an antimicrobial, anti-oxidant study, the effect of substitution on the activity and possible structure activity relationship of the compounds for their antioxidant activity is presente

Synthesis of 2,5-disubstituted-1,3,4-oxadiazoles using ethyl oleate as precursor

Ethyl oleate (1) reacts with hydrazine hydrate to form stearic acid hydrazide (2), the reaction proceeds with the simultaneous reduction of 9,10 C=C bond of ethyl oleate. The stearic acid hydrazide formed on intermolecular cyclisation with different aliphatic acids, aromatic acids (3), or ethyl oleate (1) in the presence of phosphorus oxychloride forms 2,5-disubstituted 1,3,4-oxadiazoles (4) in good yield. The structure proofs of the product were confirmed by spectral studies and elemental analysis

3-Methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazole

In the title compound, C16H16N2, the dihydropyrazole ring adopts a shallow envelope conformation, with the C atom bearing the phenyl group displaced by 0.298 (2) Å from the other atoms (r.m.s. deviation = 0.015 Å). The dihedral angles between the four near coplanar atoms of the central ring and the N- and C-bonded phenyl groups are 13.49 (13) and 82.22 (16)°, respectively

Evaluation of new pyrazole derivatives for their biological activity: Structure-activity relationship

A series of new 3-Aryl-4-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitriles (1) were screened in vitro for their antibacterial and antifungal activities against four different organisms. The minimal inhibitory concentration (MIC's) was determined against each organism. The compounds were tested for their antioxidant activity and reducing power ability. The effect of substitution on the activity, and the 0possible structure activity relationship mechanism of the compounds for their antioxidant activity are presented