1,187 research outputs found
Cervical Screening at Age 50-64 Years and the Risk of Cervical Cancer at Age 65 Years and Older: Population-Based Case Control Study
This work was supported by Cancer Research UK [C8162/10406 and C8162/12537]
Line versus Flux Statistics -- Considerations for the Low Redshift Lyman-alpha Forest
The flux/transmission power spectrum has become a popular statistical tool in
studies of the high redshift () Lyman-alpha forest. At low redshifts,
where the forest has thinned out into a series of well-isolated absorption
lines, the motivation for flux statistics is less obvious. Here, we study the
relative merits of flux versus line correlations, and derive a simple condition
under which one is favored over the other on purely statistical grounds.
Systematic errors probably play an important role in this discussion, and they
are outlined as well.Comment: 6 pages, to appear in "The IGM/Galaxy Connection: The Distribution of
Baryons at z=0", eds. J. L. Rosenberg and M. E. Putma
Risk of preterm delivery with increasing depth of excision for cervical intraepithelial neoplasia in England: nested case-control study
Objective To determine the association between depth of excision of cervical intraepithelial neoplasia and risk of preterm birth. Design Case-control study nested in record linkage cohort study. Setting 12 hospitals in England. Participants From a cohort of 11 471 women with at least one histological sample taken at colposcopy and a live singleton birth (before or after colposcopy), 1313 women with a preterm birth (20-36 weeks) were identified and frequency matched on maternal age at delivery, parity, and study site to 1313 women with term births (38-42 weeks). Main outcome measures Risk of preterm birth and very/extreme preterm birth by depth of excisional treatment of the cervical transformation zone. Results After exclusions, 768 preterm births (cases) and 830 term births after colposcopy remained. The risk of preterm birth was no greater in women with a previous small (<10 mm) excision (absolute risk 7.5%, 95% confidence interval 6.0% to 8.9%) than in women with a diagnostic punch biopsy (7.2%, 5.9% to 8.5%). Women with a medium (10-14 mm) (absolute risk 9.6%; relative risk 1.28, 0.98 to 1.68), large (15-19 mm) (15.3%; 2.04, 1.41 to 2.96), or very large (≥20 mm) excision (18.0%; 2.40, 1.53 to 3.75) had a higher risk of preterm delivery than those with small excision. The same pattern was seen in 161 women with very/extremely preterm births (20-31 weeks) and with increasing volume excised. Most births were conceived more than three years after colposcopy, and the risk of preterm delivery did not seem to depend on time from excision to conception. Conclusions The risk of preterm birth is at most minimally affected by a small excision. Larger excisions, particularly over 15 mm or 2.66 cm(3), are associated with a doubling of the risk of both preterm and very preterm births. The risk does not decrease with increasing time from excision to conception. Efforts should be made to excise the entire lesion while preserving as much healthy cervical tissue as possible. Close obstetric monitoring is warranted for women who have large excisions of the cervical transformation zone
Cumulants as non-Gaussian qualifiers
We discuss the requirements of good statistics for quantifying
non-Gaussianity in the Cosmic Microwave Background. The importance of
rotational invariance and statistical independence is stressed, but we show
that these are sometimes incompatible. It is shown that the first of these
requirements prefers a real space (or wavelet) formulation, whereas the latter
favours quantities defined in Fourier space. Bearing this in mind we decide to
be eclectic and define two new sets of statistics to quantify the level of
non-Gaussianity. Both sets make use of the concept of cumulants of a
distribution. However, one set is defined in real space, with reference to the
wavelet transform, whereas the other is defined in Fourier space. We derive a
series of properties concerning these statistics for a Gaussian random field
and show how one can relate these quantities to the higher order moments of
temperature maps. Although our frameworks lead to an infinite hierarchy of
quantities we show how cosmic variance and experimental constraints give a
natural truncation of this hierarchy. We then focus on the real space
statistics and analyse the non-Gaussian signal generated by points sources
obscured by large scale Gaussian fluctuations. We conclude by discussing the
practical implementations of these techniques
The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage
Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction. The aim of this study was to elucidate further the underlying mechanisms responsible for dysfunctional T-cells and their interaction with APCs following trauma-hemorrhage.
Design: Adult C3H/HeN male mice were subjected to trauma-hemorrhage (3-cm midline laparotomy) followed by hemorrhage (blood pressure of 35�5mmHg for 90 min and resuscitation) or sham operation. At 24 h thereafter, spleens were harvested and T-cells (by Microbeads) and APCs (via adherence) were Isolated. Co-cultures of T-cells and APCs were established for 48 h and stimulated with concanavalin A and lipopolysaccharide. T-Cell specific cytokines known to affect APC function (i.e. interleukin(IL)-2, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF)) were measured in culture supernatants by Multiplex assay. The expression of MHC class II as well as co-stimulatory surface molecules on T-cells and APCs was determined by flow cytometry.
Results: The release of IL-4 and GM-CSF by T-cells was suppressed following trauma-hemorrhage, irrespective of whether sham or trauma-hemorrhage APCs were present. Antigen-presenting cells from animals subjected to trauma-hemorrhage did not affect T-cell derived cytokine release by sham T-cells. In contrast, T-cells from traumahemorrhage animals depressed MHC class II expression of CD11c(þ) cells, irrespective of whether APCs underwent sham or trauma-hemorrhage procedure. Surprisingly, co-stimulatory molecules on APCs (CD80, CD86) were not affected by trauma-hemorrhage.
Conclusions: These results suggest that beside IFN-g other T-cell derived cytokines contribute to immunosuppression following trauma-hemorrhage causing diminished MHC II expression on APCs. Thus, T-cells appear to play an important role in this interaction at the time-point examined. Therapeutic approaches should aim at maintenance of T-cell function and their interaction with APCs to prevent extended immunosuppression following trauma-hemorrhage
A 120-Mpc Periodicity in the Three-Dimensional Distribution of Galaxy Superclusters
Using a new compilation of available data on galaxy clusters and
superclusters we present evidence for a quasiregular three-dimensional network
of rich superclusters and voids, with the regions of high density separated by
about 120 Mpc. We calculate the power spectrum for clusters of galaxies; it has
a peak on the wavelength equal to the step of the network; the excess in the
amplitude of the spectrum over that of the cold dark matter model is by a
factor of 1.4. The probability that the spectrum can be formed within the
framework of the standard cosmogony is very small. If the cluster distribution
reflects the distribution of all matter (luminous and dark), then there must
exists some hithero unknown process that produces regular structure on large
scales.Comment: Tex, 6 pages, 2 PostScript figures embedded, accepted by Nature on
November 19, 199
The Clustering of Colour Selected Galaxies
We present measurements of the angular correlation function of galaxies
selected from a B_J=23.5 multicolour survey of two 5 degree by 5 degree fields
located at high galactic latitudes. The galaxy catalogue of approximately
400,000 galaxies is comparable in size to catalogues used to determine the
galaxy correlation function at low-redshift. Measurements of the z=0.4
correlation function at large angular scales show no evidence for a break from
a power law though our results are not inconsistent with a break at >15 Mpc.
Despite the large fields-of-view, there are large discrepancies between the
measurements of the correlation function in each field, possibly due to dwarf
galaxies within z=0.11 clusters near the South Galactic Pole.
Colour selection is used to study the clustering of galaxies z=0 to z=0.4.
The galaxy correlation function is found to strongly depend on colour with red
galaxies more strongly clustered than blue galaxies by a factor of 5 at small
scales. The slope of the correlation function is also found to vary with colour
with gamma=1.8 for red galaxies while gamma=1.5 for blue galaxies. The
clustering of red galaxies is consistently strong over the entire magnitude
range studied though there are large variations between the two fields. The
clustering of blue galaxies is extremely weak over the observed magnitude range
with clustering consistent with r_0=2 Mpc. This is weaker than the clustering
of late-type galaxies in the local Universe and suggests galaxy clustering is
more strongly correlated with colour than morphology. This may also be the
first detection of a substantial low redshift galaxy population with clustering
properties similar to faint blue galaxies.Comment: Accepted for publication in MNRAS. 13 pages, 20 figure
The writing on the wall: the concealed communities of the East Yorkshire horselads
This paper examines the graffiti found within late nineteenth and early-twentieth century farm buildings in the Wolds of East Yorkshire. It suggests that the graffiti were created by a group of young men at the bottom of the social hierarchy - the horselads – and was one of the ways in which they constructed a distinctive sense of communal identity, at a particular stage in their lives. Whilst it tells us much about changing agricultural regimes and social structures, it also informs us about experiences and attitudes often hidden from official histories and biographies. In this way, the graffiti are argued to inform our understanding, not only of a concealed community, but also about their hidden histor
- …