INCIDENCE AND MANAGEMENT OF TREATMENT-RELATED SIDE EFFECTS FOR PATIENTS RECEIVING PLATINUM THERAPY IN AN OUTPATIENT ONCOLOGY CLINIC

  Objective: Platinum agents (PAs) are the most commonly used chemotherapeutic agents, aiming to induce tumor cell death by cytotoxicity. This leads to have high potential for toxicity and adverse effects. The main objectives of this study were to describe the incidence of side effects caused by platinum therapy and to conclude the management of treatment-related side effects for patients receiving platinum therapy.Methods: A descriptive, retrospective study was carried out over a period of 9 months. Laboratory reports of 100 cancer patients were recorded. All statistical analyses were performed using SPSS 17.0 and GraphPad Prism. A p<0.05 (95% confidence interval) was considered significantly throughout the study.Results: Among 100 patients 55% were male and 45% were female. A total of 70% (n=70) patients who received platinum compounds as chemotherapy regimen, among them 97.14% (n=68) patients appears to have anemia. Among the occurrence of adverse drug reactions, the incidence of anemia was found to be significant (n=68, 97.14%). Statistically significant difference was found in the incidence of anemia between PAs and non- PAs treated group (p=0.0001).Conclusion: Among PAs cisplatin-induced anemia and nephrotoxicity appears to be high in this study. There is a need to improve the management of anemia induced by PAs. Since anemia is preventable, this study emphasizes the need to improve the management of anemia induced by PAs

Return and Volatility Spillovers of Asian Pacific Stock Markets’ Energy Indices

The aim of the study was to investigate the presence of volatility among the Energy Indices of Asia Pacific Stock Markets. To test the volatility among the daily returns of Energy Indices of Asia Pacific Stock Markets, the study selected five sample Asian Pacific stock markets’ Energy Indices on the basis of availability of data. The findings of descriptive statistics and the ADF Test revealed, that the daily returns of the sample energy indices of Asian Pacific stock markets were not normally distributed and achieved stationarity at level difference, over the research period. Hence the data may be used for additional analysis. The data were then analysed, by using the GARCH (1,1) model to assess the considerable volatility of daily returns of sample energy indices and the study, which revealed that during the study period, all of the sample energy indices were volatile

The restoration of subjectivity in the context of duality and struggle in Michelle cliff's: No telephone to heaven

This study claims that colonialism and patriarchy both oppress postcolonial women. Discursive practices that incorrectly depict women as passive victims sometimes obscure the actions of resistance committed by women. Women's subjugation is documented in Abeng and No Telephone To Heaven by Michelle Cliff to remedy this portrayal of women. Cliff breaks the colonial and patriarchal illusions that make women helpless. According to this idea, the liminal zone is crucial for empowerment and resistance. "Third Space" is a term coined by Homi K. Bhabha to describe an individual's ability to inhabit two distinct universes simultaneously. Migrants like Michelle Cliff can witness and document the oppression and struggle of the colonized from this Third Space. Using postcolonial theory, the paper explains the colonized's fractured and conflicting experiences

INCIDENCE AND MANAGEMENT OF TREATMENT-RELATED SIDE EFFECTS FOR PATIENTS RECEIVING PLATINUM THERAPY IN AN OUTPATIENT ONCOLOGY CLINIC

  Objective: Platinum agents (PAs) are the most commonly used chemotherapeutic agents, aiming to induce tumor cell death by cytotoxicity. This leads to have high potential for toxicity and adverse effects. The main objectives of this study were to describe the incidence of side effects caused by platinum therapy and to conclude the management of treatment-related side effects for patients receiving platinum therapy.Methods: A descriptive, retrospective study was carried out over a period of 9 months. Laboratory reports of 100 cancer patients were recorded. All statistical analyses were performed using SPSS 17.0 and GraphPad Prism. A p<0.05 (95% confidence interval) was considered significantly throughout the study.Results: Among 100 patients 55% were male and 45% were female. A total of 70% (n=70) patients who received platinum compounds as chemotherapy regimen, among them 97.14% (n=68) patients appears to have anemia. Among the occurrence of adverse drug reactions, the incidence of anemia was found to be significant (n=68, 97.14%). Statistically significant difference was found in the incidence of anemia between PAs and non- PAs treated group (p=0.0001).Conclusion: Among PAs cisplatin-induced anemia and nephrotoxicity appears to be high in this study. There is a need to improve the management of anemia induced by PAs. Since anemia is preventable, this study emphasizes the need to improve the management of anemia induced by PAs

To evaluate the quality of successful ultrasound guided supraclavicular brachial plexus block and its correlation with perfusion index ratio

Background: Ultrasound-guided supraclavicular nerve block is a popular approach for anesthesia for upper limb surgeries. Perfusion index can considered as an objective measure for peripheral perfusion that can predict peripheral block success. Early and accurate detection of peripheral block success would enable rapid corrective action this would save the operating room time and improve patient satisfaction. The main objective was to evaluate the quality of supraclavicular brachial plexus block and it’s correlation with Perfusion Index ratio.  Method: It was a prospective observational study carried out over a period of 18 months from November 2018 to April 2020 in the department of anesthesia. Patients aged between 18 to 65 years. Written informed consent, 30 patients of either sex, belonging to ASA grade I and II, scheduled for elective upper limb, under supraclavicular brachial plexus block were selected for the study. Quality of block was made on the basis of 3 point scale. Result: In this study we observed that the Perfusion index was significantly higher in blocked limbed at all time points.&nbsp

Evaluation of Performance of Turmeric (Curcuma longa L.) Varieties in Dharmapuri District of Tamil Nadu, India

Turmeric is an important spice crop cultivated in various states of India and Tamil Nadu is one of the leading producers of Turmeric. The productivity of Turmeric in Tamil Nadu was 3.80 MT/ha (cured rhizome yield) which is lower than the national productivity. Though there are various factors affecting productivity, choice of varieties was one of the important factors among them. On farm trials were conducted to study the performance of Turmeric varieties viz. BSR 1, BSR 2, CO 2, Allepey Supreme, PTS 10 and Roma at Krishi Vigyan Kendra, Papparapatty of Dharmapuri district. The experiment was conducted in randomized block design with three replications. The crop management practices are carried out as per Crop Production Guide 2020 of Tamil Nadu Agricultural University, Coimbatore recommendation. The yield data revealed that there was significant variation among the turmeric varieties in various growth and yield determining parameters. Among the varieties CO 2 performed better than the other varieties with highest yield per plant (468.99 g), cured rhizome yield per hectare (6.82 tonnes/ha) followed by BSR 2. The results of the study show that CO 2 performed better in Dharmapuri district when compared to other varieties and hence can be preferably recommended to the farmers for better yield. The yield attributing factors viz. plant height, leaf size, weight of mother rhizome, weight and number of primary and secondary fingers are positively correlated with the yield per plant and hence can be used as criteria for varietal selection

The Risk Factors and Outcome of Fungal Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients

Aim: To determine the risk factors and outcome of fungal peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 7-year period. Patients and Methods: This retrospective study was conducted on 30 cases of fungal peritonitis in CAPD patients during a 7-year period (2000-2007). The diagnosis was based on elevated CAPD effluent count and isolation of fungi. Patients were evaluated for previous episode of bacterial peritonitis. Results: The incidence of fungal peritonitis was 16.2%. Age varied between 8 and 75 years, with a mean age of 57 years. Twenty-three were males (76.7%) and seven were females (23.3%). Seventeen patients (56.6%) had previous episodes of bacterial peritonitis that was treated with multiple antibiotics. The common fungus was Candida species (50%). CAPD catheter removal and initiation of antifungal therapy was done for all patients. Reinsertion was done for three (10%) patients. Mortality rate was 20%. Conclusion: Patients with previous bacterial peritonitis and antibiotic usage are at greater risk of developing fungal peritonitis

A rare case of pancake kidney with glomerulonephritis

Developmental anomalies of the kidney and the urinary tract occur in 3-6 per 1000 live births. Pancake kidney is one of the rarest types of renal ectopia. Urinary system anomalies often coexist with malformations of other organs and systems. We report a case of pancake kidney which was detected incidentally while treating a patient with renal failure and nephrotic syndrome