Central activity in 60 micron peakers

The authors present charge coupled device (CCD) imaging results of their sample of Infrared Astronomy Satellite (IRAS) galaxies with spectral energy distributions peaking at 60 microns (Vader et al 1988). The results support the author's suggestion that the activity in 60 micron peaking galaxies is centrally concentrated, and represents an early stage of dust-embedded nuclear activity. This activity is probably triggered by a recent interaction/merger event as indicated by their peculiar optical morphologies. The authors propose that 60 micron peakers are the precursors of SO's in the case of amorphous systems, and ellipticals in the case of interacting galaxies

Pattern formation during de novo assembly of the Arabidopsis shoot meristem

Most multicellular organisms have a capacity to regenerate tissue after wounding. Few, however, have the ability to regenerate an entire new body from adult tissue. Induction of new shoot meristems from cultured root explants is a widely used, but poorly understood, process in which apical plant tissues are regenerated from adult somatic tissue through the de novo formation of shoot meristems. We characterize early patterning during de novo development of the Arabidopsis shoot meristem using fluorescent reporters of known gene and protein activities required for shoot meristem development and maintenance. We find that a small number of progenitor cells initiate development of new shoot meristems through stereotypical stages of reporter expression and activity of CUP-SHAPED COTYLEDON 2 (CUC2), WUSCHEL (WUS), PIN-FORMED 1 (PIN1), SHOOT-MERISTEMLESS (STM), FILAMENTOUS FLOWER (FIL, also known as AFO), REVOLUTA (REV), ARABIDOPSIS THALIANA MERISTEM L1 LAYER (ATML1) and CLAVATA 3 (CLV3). Furthermore, we demonstrate a functional requirement for WUS activity during de novo shoot meristem initiation. We propose that de novo shoot meristem induction is an easily accessible system for the study of patterning and self-organization in the well-studied model organism Arabidopsis

Formative evaluation and adaptation of pre-and early implementation of diabetes shared medical appointments to maximize sustainability and adoption

Abstract Background Understanding the many factors that influence implementation of new programs, in addition to their success or failure, is extraordinarily complex. This qualitative study examines the implementation and adaptation process of two linked clinical programs within Primary Care, diabetes shared medical appointments (SMAs) and a reciprocal Peer-to-Peer (P2P) support program for patients with poorly controlled diabetes, through the lens of the Consolidated Framework for Implementation Research (CFIR). We illustrate the role and importance of pre-implementation interviews for guiding ongoing adaptations to improve implementation of a clinical program, achieve optimal change, and avoid type III errors. Methods We conducted 28 semi-structured phone interviews between September of 2013 and May of 2016, four to seven interviewees at each site. The interviewees were physician champions, chiefs of primary care, pharmacists, dieticians, nurses, health psychologists, peer facilitators, and research coordinators. Modifiable barriers and facilitators to implementation were identified and adaptations documented. Data analysis started with immersion in the data to obtain a sense of the whole and then by cataloging principal themes per CFIR constructs. An iterative consensus-building process was used to code. CFIR constructs were then ranked and compared by the researchers. Results We identified a subset of CFIR constructs that are most likely to play a role in the effectiveness of the diabetes SMAs and P2P program based on our work with the participating sites to date. Through the identification of barriers and facilitators, a subset of CFIR constructs arose, including evidence strength and quality, relative advantage, adaptability, complexity, patient needs and resources, compatibility, leadership engagement, available resources, knowledge and beliefs, and champions. Conclusions We described our method for identification of contextual factors that influenced implementation of complex diabetes clinical programs - SMAs and P2P. The qualitative phone interviews aided implementation through the identification of modifiable barriers or conversely, actionable findings. Implementation projects, and certainly clinical programs, do not have unlimited resources and these interviews allowed us to determine which facets to target and act on for each site. As the study progresses, these findings will be compared and correlated to outcome measures. This comprehensive adaptation data collection will also facilitate and enhance understanding of the future success or lack of success of implementation and inform potential for translation and public health impact. The approach of using the CFIR to guide us to actionable findings and help us better understand barriers and facilitators has broad applicability and can be used by other projects to guide, adapt, and improve implementation of research into practice. Trial registration ClinicalTrials.gov ID: NCT02132676 .https://deepblue.lib.umich.edu/bitstream/2027.42/144538/1/12875_2018_Article_797.pd

COLA II - Radio and Spectroscopic Diagnostics of Nuclear Activity in Galaxies

We present optical spectroscopic observations of 93 galaxies taken from the infra-red selected COLA (Compact Objects in Low Power AGN) sample. The sample spans the range of far-IR luminosities from normal galaxies to LIRGs. Of the galaxies observed, 78 (84%) exhibit emission lines. Using a theoretically-based optical emission-line scheme we classify 15% of the emission-line galaxies as Seyferts, 77% as starbursts, and the rest are either borderline AGN/starburst or show ambiguous characteristics. We find little evidence for an increase in the fraction of AGN in the sample as a function of far-IR luminosity but our sample covers only a small range in infrared luminosity and thus a weak trend may be masked. As a whole the Seyfert galaxies exhibit a small, but significant, radio excess on the radio-FIR correlation compared to the galaxies classified as starbursts. Compact (<0.05'') radio cores are detected in 55% of the Seyfert galaxies, and these galaxies exhibit a significantly larger radio excess than the Seyfert galaxies in which cores were not detected. Our results indicate that there may be two distinct populations of Seyferts, ``radio-excess'' Seyferts, which exhibit extended radio structures and compact radio cores, and ``radio-quiet'' Seyferts, in which the majority of the radio emission can be attributed to star-formation in the host galaxy. No significant difference is seen between the IR and optical spectroscopic properties of Seyferts with and without radio cores. (Abridged)Comment: 24 pages, 4 figures, 6 tables. Accepted for publication in ApJ, February 200

Physician assessments of medication adherence and decisions to intensify medications for patients with uncontrolled blood pressure: still no better than a coin toss

Abstract Background Many patients have uncontrolled blood pressure (BP) because they are not taking medications as prescribed. Providers may have difficulty accurately assessing adherence. Providers need to assess medication adherence to decide whether to address uncontrolled BP by improving adherence to the current prescribed regimen or by intensifying the BP treatment regimen by increasing doses or adding more medications. Methods We examined how provider assessments of adherence with antihypertensive medications compared with refill records, and how providers’ assessments were associated with decisions to intensify medications for uncontrolled BP. We studied a cross-sectional cohort of 1169 veterans with diabetes presenting with BP ≥140/90 to 92 primary care providers at 9 Veterans Affairs (VA) facilities from February 2005 to March 2006. Using VA pharmacy records, we utilized a continuous multiple-interval measure of medication gaps (CMG) to assess the proportion of time in prior year that patient did not possess the prescribed medications; CMG ≥20% is considered clinically significant non-adherence. Providers answered post-visit Likert-scale questions regarding their assessment of patient adherence to BP medications. The BP regimen was considered intensified if medication was added or increased without stopping or decreasing another medication. Results 1064 patients were receiving antihypertensive medication regularly from the VA; the mean CMG was 11.3%. Adherence assessments by providers correlated poorly with refill history. 211 (20%) patients did not have BP medication available for ≥ 20% of days; providers characterized 79 (37%) of these 211 patients as having significant non-adherence, and intensified medications for 97 (46%). Providers intensified BP medications for 451 (42%) patients, similarly whether assessed by provider as having significant non-adherence (44%) or not (43%). Conclusions Providers recognized non-adherence for less than half of patients whose pharmacy records indicated significant refill gaps, and often intensified BP medications even when suspected serious non-adherence. Making an objective measure of adherence such as the CMG available during visits may help providers recognize non-adherence to inform prescribing decisions.http://deepblue.lib.umich.edu/bitstream/2027.42/112850/1/12913_2012_Article_2450.pd

Study protocol: The Adherence and Intensification of Medications (AIM) study - a cluster randomized controlled effectiveness study

Abstract Background Many patients with diabetes have poor blood pressure (BP) control. Pharmacological therapy is the cornerstone of effective BP treatment, yet there are high rates both of poor medication adherence and failure to intensify medications. Successful medication management requires an effective partnership between providers who initiate and increase doses of effective medications and patients who adhere to the regimen. Methods In this cluster-randomized controlled effectiveness study, primary care teams within sites were randomized to a program led by a clinical pharmacist trained in motivational interviewing-based behavioral counseling approaches and authorized to make BP medication changes or to usual care. This study involved the collection of data during a 14-month intervention period in three Department of Veterans Affairs facilities and two Kaiser Permanente Northern California facilities. The clinical pharmacist was supported by clinical information systems that enabled proactive identification of, and outreach to, eligible patients identified on the basis of poor BP control and either medication refill gaps or lack of recent medication intensification. The primary outcome is the relative change in systolic blood pressure (SBP) measurements over time. Secondary outcomes are changes in Hemoglobin A1c, low-density lipoprotein cholesterol (LDL), medication adherence determined from pharmacy refill data, and medication intensification rates. Discussion Integration of the three intervention elements - proactive identification, adherence counseling and medication intensification - is essential to achieve optimal levels of control for high-risk patients. Testing the effectiveness of this intervention at the team level allows us to study the program as it would typically be implemented within a clinic setting, including how it integrates with other elements of care. Trial Registration The ClinicalTrials.gov registration number is NCT00495794.http://deepblue.lib.umich.edu/bitstream/2027.42/78258/1/1745-6215-11-95.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78258/2/1745-6215-11-95.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/78258/3/1745-6215-11-95-S1.DOCPeer Reviewe

SBF Distances to Dwarf Elliptical Galaxies in the Sculptor Group

As part of an ongoing search for dwarf elliptical galaxies (dE) in the vicinity of the Local Group, we acquired deep B and R-band images for five dE candidates identified in the Sculptor (Scl) group region. We carried out a surface brightness fluctuation (SBF) analysis on the R-band images to measure the apparent fluctuation magnitude \bar{m}_R for each dE. Using predictions from stellar population synthesis models the galaxy distances were determined. All of these dE candidates turned out to be satellites of Scl group major members. A redshift measurement of the dE candidate ESO294-010 yielded an independent confirmation of its group membership: the [OIII] and H$_\alpha$ emission lines from a small HII region gave a heliocentric velocity of 117(\pm 5) km s-1, in close agreement with the velocity of its parent galaxy NGC 55 (v_\odot=125 km s-1). The precision of the SBF distances (5 to 10%) contributes to delineating the cigar-like distribution of the Scl group members, which extend over distances from 1.7 to 4.4 Mpc and are concentrated in three, possibly four subclumps. The Hubble diagram for nine Scl galaxies, including two of our dEs, exhibits a tight linear velocity--distance relation with a steep slope of 119 km s-1 Mpc-1. The results indicate that gravitational interaction among the Scl group members plays only a minor role in the dynamics of the group. However, the Hubble flow of the entire system appears strongly disturbed by the large masses of our Galaxy and M31 leading to the observed shearing motion. From the distances and velocities of 49 galaxies located in the Local Group and towards the Scl group, we illustrate the continuity of the galaxy distribution which strongly supports the view that the two groups form a single supergalactic structure.Comment: To appear in The Astronomical Journal, December 1998; 28 pages with 22 figure

3D Spectroscopic Observations of Star-Forming Dwarf Galaxies

We give an introduction into the observational technique of integral field or 3D spectroscopy. We discuss advantages and drawbacks of this type of observations and highlight a few science projects enabled by this method. In the second part we describe our 3D spectroscopic survey of Blue Compact Dwarf Galaxies. We show preliminary results from data taken with the VIMOS integral field unit and give an outlook on how automated spectral analysis and forthcoming instruments can provide a new view on star formation and associated processes in dwarf galaxies.Comment: To appear in the proceedings of the JENAM 2010 Symposium "Dwarf Galaxies: Keys to Galaxy Formation and Evolution" (Lisbon, 9-10 September 2010), P. Papaderos, S. Recchi, G. Hensler (eds.), Springer Verlag (2011), in pres

Radio-Luminous Southern Seyfert Galaxies. I. Radio Images and Selected Optical/Near-Infrared Spectroscopy

This is the first of two papers in which a study is made of a sample of 12 southern radio-luminous Seyfert galaxies. Our aim is to investigate possible correlations between radio morphology and nuclear/circumnuclear emission-line properties. In this paper we present radio images at 13, 6, and 3 cm taken with the Australia Telescope Compact Array (ATCA), global far-infrared (FIR) properties for the whole sample, and optical and near-infrared (NIR) spectroscopy of an interesting subset. We find a mixture of radio morphologies, including linear, diffuse and compact sources. When the FIR colors of the galaxies are considered there is an indication that the compact radio sources have warmer FIR colors than the diffuse sources, whereas the linear sources span a wide range of FIR colors. There is a wide variation in radio spectral-indices, suggesting that free-free absorption is significant in some systems, particularly IRAS 11249-2859, NGC 4507, and NGC 7213. Detailed emission-line studies are presented of 4 galaxies IC 3639, NGC 5135, NGC 3393 & IRAS 11249-2859. In IC 3639 we present evidence of vigorous, compact star formation enclosed by very extended [OI]6300 emission, suggestive of the boundary between a diffuse outflow and the surrounding ISM. In another galaxy, IC 5063, we see evidence for the possible interaction of a highly collimated outflow and the surrounding rotating inner disk. Of the 5 galaxies which show compact radio emission, 4 have radio/FIR flux ratios consistent with an energetically dominant AGN, whereas IC 4995 exhibits evidence for a very compact starburst.Comment: 42 pages, including 7 tables, latex, 19 jpeg figures, Accepted to ApJ. Replacement updates coordintes of galaxies in Table

Large-Scale Structure at z~2.5

We have made a statistically complete, unbiased survey of C IV systems toward a region of high QSO density near the South Galactic Pole using 25 lines of sight spanning $1.5<z<2.8$. Such a survey makes an excellent probe of large-scale structure at early epochs. We find evidence for structure on the $15-35h^{-1}$ proper Mpc scale ($H_0 \equiv 100$ km $s^{-1}$ Mpc${-1}$) as determined by the two point C IV - C IV absorber correlation function, and reject the null hypothesis that C IV systems are distributed randomly on such scales at the $\sim 3.5\sigma$ level. The structure likely reflects the distance between two groups of absorbers subtending $\sim~ 13 \times 5 \times 21h^{-3}$ and $\sim 7 \times 1 \times 15h^{-3}$ Mpc$^3$ at $z\sim 2.3$ and $z \sim 2.5$ respectively. There is also a marginal trend for the association of high rest equivalent width C IV absorbers and QSOs at similar redshifts but along different lines of sight. The total number of C IV systems detected is consistent with that which would be expected based on a survey using many widely separated lines of sight. Using the same data, we also find 11 Mg II absorbers in a complete survey toward 24 lines of sight; there is no evidence for Mg II - Mg II or Mg II - QSO clustering, though the sample size is likely still small to detect such structure if it exists.Comment: 56 pages including 32 of figures, in gzip-ed uuencoded postscript format, 1 long table not included, aastex4 package. Accepted for publication in ApJ Supplement