8 research outputs found
Prognostic Significance of Location of the Primary Tumor in Operable Breast Cancers
Background: The prognostic significance of the primary tumor site in
breast cancers is not established with only a few studies having
evaluated the issue. Materials and Methods: The relevance of a primary
tumor site with respect to systemic disease relapse was evaluated in
187 patients with breast cancer treated with primary surgery and
adjuvant chemotherapy, in whom the location of primary tumor was
classifiable in any one of the three sites, namely: outer, periareolar,
and inner, quadrants. Data was obtained from prospectively maintained
records of breast cancer patients treated at a single surgical unit in
a tertiary care center. Results: The three groups were comparable with
regard to demographic, pathological tumor, and treatment
characteristics. In the multivariate analysis, patients with inner and
periareolar quadrant tumors had a higher hazard for systemic disease
relapse, (2.53, 95% CI: 1.18-5.42; P = 0.02, and 2.73, 95% CI:
1.04-7.14; P = 0.04, respectively) as compared to outer quadrant
tumors. The projected five-year survival estimates in Kaplan Meier were
87%, 61%, and 69%, respectively, for outer, periareolar, and inner
quadrant. On further substratification the difference was particularly
noted in high risk inner quadrant tumors: age 64 45, premenopausal
patients, tumor size> 2 cms, positive nodes and intermediate or high
grade histology, as also in patients treated with breast conservation
and CMF, Cyclophosphamide, Methorexate, 5 Fluorouracil chemotherapy.
Conclusion: The location of the primary tumor influences survival in
breast cancer with inferior outcome for tumors in inner and periareolar
quadrants, especially in high risk groups and those treated with
conservative approaches. The role of aggressive therapies merits
investigation in these patients
Prognostic Significance of Location of the Primary Tumor in Operable Breast Cancers
Background: The prognostic significance of the primary tumor site in
breast cancers is not established with only a few studies having
evaluated the issue. Materials and Methods: The relevance of a primary
tumor site with respect to systemic disease relapse was evaluated in
187 patients with breast cancer treated with primary surgery and
adjuvant chemotherapy, in whom the location of primary tumor was
classifiable in any one of the three sites, namely: outer, periareolar,
and inner, quadrants. Data was obtained from prospectively maintained
records of breast cancer patients treated at a single surgical unit in
a tertiary care center. Results: The three groups were comparable with
regard to demographic, pathological tumor, and treatment
characteristics. In the multivariate analysis, patients with inner and
periareolar quadrant tumors had a higher hazard for systemic disease
relapse, (2.53, 95% CI: 1.18-5.42; P = 0.02, and 2.73, 95% CI:
1.04-7.14; P = 0.04, respectively) as compared to outer quadrant
tumors. The projected five-year survival estimates in Kaplan Meier were
87%, 61%, and 69%, respectively, for outer, periareolar, and inner
quadrant. On further substratification the difference was particularly
noted in high risk inner quadrant tumors: age ≤ 45, premenopausal
patients, tumor size> 2 cms, positive nodes and intermediate or high
grade histology, as also in patients treated with breast conservation
and CMF, Cyclophosphamide, Methorexate, 5 Fluorouracil chemotherapy.
Conclusion: The location of the primary tumor influences survival in
breast cancer with inferior outcome for tumors in inner and periareolar
quadrants, especially in high risk groups and those treated with
conservative approaches. The role of aggressive therapies merits
investigation in these patients
Effect of preoperative short course famotidine on TILs and survival in breast cancer
Background: Histamine receptor antagonists have been shown to induce
tumor-infiltrating lymphocytes (TILs) in colonic cancers and improve
survival. The role of histamine receptor anatagonists in breast cancer
is unclarified. Aim: To evaluate the role of histamine receptor
antagonists in inducing (TILs) in breast cancer. Method: Forty-five
patients with operable breast cancers (25 cases who received
preoperative famotidine and 20 controls) were studied for the effect of
famotidine in inducing TILs and survival in breast cancer. Results:
Significant TILs were seen in 75% (18/24) of cases as opposed to 35%
(7/20) controls. In logistic regression analysis the only variable
found to be predictive of TILs was famotidine, odds ratio 7.324
(1.693-31.686) P = 0.008. In Cox\u2032s regression presence of TILs
was favorably associated with improved disease free survival at a
median follow up of 35.56 months. The hazard ratio for disease relapse
was 3.327 (1.174-9.426) P = 0.024 in TIL negative as compared to TIL
positive patients. Famotidine use alone was not significant in the
original model, however, on incorporation of quadrant of involvement in
addition to other established prognostic factors in the above
multivariate model, it assumed borderline significance with a hazard
ratio for disease free survival 3.404 (1.005-11.531, P = 0.049).
Conclusions: Preoperative short course famotidine induces TILs in
breast cancer. Patients with TILs demonstrable in tumor specimens had
an improved disease free survival. Famotidine may improve disease free
survival in breast cancer and these findings need validation in larger
population subsets
Effect of preoperative short-course famotidine on TILs and survival in breast cancer
Background: Histamine receptor antagonists have been shown to induce
tumor-infiltrating lymphocytes (TILs) in colonic cancers and improve
survival. The role of histamine receptor anatagonists in breast cancer
is unclarified. Aim: To evaluate the role of histamine receptor
antagonists in inducing (TILs) in breast cancer. Method: Forty-five
patients with operable breast cancers (25 cases who received
preoperative famotidine and 20 controls) were studied for the effect of
famotidine in inducing TILs and survival in breast cancer. Results:
Significant TILs were seen in 75% (18/24) of cases as opposed to 35%
(7/20) controls. In logistic regression analysis the only variable
found to be predictive of TILs was famotidine, odds ratio 7.324
(1.693-31.686) P = 0.008. In Cox′s regression presence of TILs
was favorably associated with improved disease free survival at a
median follow up of 35.56 months. The hazard ratio for disease relapse
was 3.327 (1.174-9.426) P = 0.024 in TIL negative as compared to TIL
positive patients. Famotidine use alone was not significant in the
original model, however, on incorporation of quadrant of involvement in
addition to other established prognostic factors in the above
multivariate model, it assumed borderline significance with a hazard
ratio for disease free survival 3.404 (1.005-11.531, P = 0.049).
Conclusions: Preoperative short course famotidine induces TILs in
breast cancer. Patients with TILs demonstrable in tumor specimens had
an improved disease free survival. Famotidine may improve disease free
survival in breast cancer and these findings need validation in larger
population subsets