3,531 research outputs found
Bacterial Cholangitis, Cholecystitis, or both in Dogs
BACKGROUND: Bacterial cholangitis and cholecystitis are rarely reported, poorly characterized diseases in the dog. OBJECTIVES: To characterize the clinical features of these conditions. ANIMALS: Twentyâseven clientâowned dogs with bacterial cholangitis, cholecystitis, or both. METHODS: Multicenter, retrospective cases series of dogs with bacterial cholangitis, cholecystitis, or both, presenting January 2000 to June 2011 to 4 Veterinary Schools in Ireland/United Kingdom. Interrogation of hospital databases identified all cases with the inclusion criteria; histopathologically confirmed cholangitis or cholecystitis and bile culture/cytology results supporting a bacterial etiology. RESULTS: Twentyâseven dogs met the inclusion criteria with approximately 460 hepatitis cases documented over the same study period. Typical clinical pathology findings were increases in liver enzyme activities (25/26), hyperbilirubinemia (20/26), and an inflammatory leukogram (21/24). Ultrasound findings, although nonspecific, aided decisionâmaking in 25/26 cases. The most frequent hepatobiliary bacterial isolates were Escherichia coli (n = 17; 16 cases), Enterococcus spp. (n = 8; 6 cases), and Clostridium spp. (n = 5; 5 cases). Antimicrobial resistance was an important feature of aerobic isolates; 10/16 E. coli isolates resistant to 3 or more antimicrobial classes. Biliary tract rupture complicated nearly one third of cases, associated with significant mortality (4/8). Discharged dogs had a guarded to fair prognosis; 17/18 alive at 2 months, although 5/10 reâevaluated had persistent liver enzyme elevation 2â12 months later. CONCLUSION AND CLINICAL SIGNIFICANCE: Bacterial cholangitis and cholecystitis occur more frequently than suggested by current literature and should be considered in dogs presenting with jaundice and fever, abdominal pain, or an inflammatory leukogram or with ultrasonographic evidence of gallbladder abnormalities
An experimental study of the rearrangements of valence protons and neutrons amongst single-particle orbits during double {\beta} decay in 100Mo
The rearrangements of protons and neutrons amongst the valence
single-particle orbitals during double {\beta} decay of 100Mo have been
determined by measuring cross sections in (d,p), (p,d), (3He,{\alpha}) and
(3He,d) reactions on 98,100Mo and 100,102Ru targets. The deduced nucleon
occupancies reveal significant discrepancies when compared with theoretical
calculations; the same calculations have previously been used to determine the
nuclear matrix element associated with the decay probability of double {\beta}
decay of the 100Mo system.Comment: 18 pages, 13 figures, 37 pages of supplemental informatio
Risk of severe COVID-19 in patients with inflammatory rheumatic diseases treated with immunosuppressive therapy in Scotland
Objective: To investigate the association of severe coronavirus disease 2019 (COVID-19) in patients with inflammatory
rheumatic diseases (IRDs) treated with immunosuppressive drugs.
Method: A list of 4633 patients on targeted â biological or targeted synthetic â DMARDs in March 2020 was linked to a caseâ
control study that includes all cases of COVID-19 in Scotland.
Results: By 22 November 2021, 433 of the 4633 patients treated with targeted DMARDS had been diagnosed with COVID-19,
of whom 58 had been hospitalized. With all those in the population not on DMARDs as the reference category, the rate ratio for
hospitalized COVID-19 associated with DMARD treatment was 2.14 [95% confidence interval (CI) 2.02â2.26] in those on
conventional synthetic (cs) DMARDs, 2.01 (95% CI 1.38â2.91) in those on tumour necrosis factor (TNF) inhibitors as the only
targeted agent, and 3.83 (95% CI 2.65â5.56) in those on other targeted DMARDs. Among those on csDMARDs, rate ratios for
hospitalized COVID-19 were lowest at 1.66 (95% CI 1.51â1.82) in those on methotrexate and highest at 5.4 (95% CI 4.4â6.7) in
those on glucocorticoids at an average dose > 10 mg/day prednisolone equivalent.
Conclusion: The risk of hospitalized COVID-19 is elevated in IRD patients treated with immunosuppressive drugs compared
with the general population. Of these drugs, methotrexate, hydroxychloroquine, and TNF inhibitors carry the lowest risk. The
highest risk is associated with prednisolone. A larger study is needed to estimate reliably the risks associated with each class of
targeted DMAR
Effects of Incorporation of Sainfoin (\u3ci\u3eOnobrychis viciafolia\u3c/i\u3e Scop.) with Cool Season Grasses on \u3ci\u3ein vitro\u3c/i\u3e Digestibility and CH4 Emission
Sainfoin (Onobrychis viciafolia Scop.) is an important non-bloating perennial leguminous forage. The tannins in sainfoin alter protein metabolism in the rumen and have been implicated in altering both nitrous oxide and methane emissions. However, the effect of sainfoin when mixed with cool-season forages is unknown. Therefore, in this study, we evaluated the in-vitro fermentation of sainfoin hay mixed with two other perennial cool-season forages, meadow bromegrass and orchardgrass at five ratios (0:100, 25:75, 50:50, 75:50, and 100:0). Data on dry matter disappearance (DMD), neutral detergent fiber disappearance (NDFD), gas production (GP) methane (CH4) emissions, and ammonia production were collected 48 h post incubation. Ruminal fluid was sourced from three heifers fed with forage hay. Incubations were conducted with and without PEG (polyethylene glycol) as PEG negates the biological activity of tannins. Sainfoin had a higher nutritive value than the other two grass species as evidenced by the higher proportion of total nitrogen and lower proportion of ADF and NDF. The change in DMD, ammonia-N, NDFD, GP, and CH4 emissions between sainfoin and grass only hay were 3.1, 9.2, -36.8, -1.76, and -1.2% respectively with the intermediate results for the mixture. The inclusion of sainfoin with cool-season grasses has positive effects on ruminal fermentation and lowered in vitro methane emissions as compared to grass alon
Chasing Brane Inflation in String-Theory
We investigate the embedding of brane anti-brane inflation into a concrete
type IIB string theory compactification with all moduli fixed. Specifically, we
are considering a D3-brane, whose position represents the inflaton , in a
warped conifold throat in the presence of supersymmetrically embedded D7-branes
and an anti D3-brane localized at the tip of the warped conifold cone. After
presenting the moduli stabilization analysis for a general D7-brane embedding,
we concentrate on two explicit models, the Ouyang and the Kuperstein
embeddings. We analyze whether the forces, induced by moduli stabilization and
acting on the D3-brane, might cancel by fine-tuning such as to leave us with
the original Coulomb attraction of the anti D3-brane as the driving force for
inflation. For a large class of D7-brane embeddings we obtain a negative
result. Cancelations are possible only for very small intervals of
around an inflection point but not globally. For the most part of its motion
the inflaton then feels a steep, non slow-roll potential. We study the
inflationary dynamics induced by this potential.Comment: 34 pages, 4 figures. Final version published in JCA
Caryospora duszynskii (Apicomplexa: Eimeriidae) from the Speckled Kingsnake, Lampropeltis holbrooki (Reptilia: Ophidia), in Arkansas, with a Summary of PreviousReports
From Data to Phenomena: A Kantian Stance
This paper investigates some metaphysical and epistemological assumptions behind Bogen and Woodward's data-to-phenomena inferences. I raise a series of points and suggest an alternative possible Kantian stance about data-to-phenomena inferences. I clarify the nature of the suggested Kantian stance by contrasting it with McAllister's view about phenomena as patterns in data sets
Initial results from the international double-blind phase III study of DysportÂź in the treatment of adults with upper limb spasticity
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