658 research outputs found

    100 Gbps PON L-band downstream transmission using IQ-MZM CD digital pre-compensation and DD ONU receiver

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    We propose a downstream direct-detection 100G-PON solution aided by chromatic dispersion digital pre-compensation using an IQ-MZM, allowing L-band operation and 29 dB power budget with low ONU complexity and without requiring single-sideband modulation

    The three-body recombination of a condensed Bose gas near a Feshbach resonance

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    In this paper, we study the three-body recombination rate of a homogeneous dilute Bose gas with a Feshbach resonance at zero temperature. The ground state and excitations of this system are obtained. The three-body recombination in the ground state is due to the break-up of an atom pair in the quantum depletion and the formation of a molecule by an atom from the broken pair and an atom from the condensate. The rate of this process is in good agreement with the experiment on 23^{23}Na in a wide range of magnetic fields.Comment: 10 pages, 2 figures, to be published in Phys. Rev.

    THE MSP RECEPTOR REGULATES ALPHA6BETA4 AND ALPHA3BETA1 INTEGRINS VIA 14-3-3 PROTEINS IN KERATINOCYTE RE-EPITHELIZATION

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    100 Gbps/λ PON downstream O- And C-band alternatives using direct-detection and linear-impairment equalization [Invited]

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    The future-generation passive optical network (PON) physical layer, targeting 100 Gbps/wavelength, will have to deal with severe optoelectronics bandwidth and chromatic dispersion limitations. In this paper, largely extending our Optical Fiber Communication Conference (OFC) 2020 invited paper, we review 100 Gbps/wavelength PON downstream alternatives over standard single-mode fiber in the O- and C-bands, analyzing three modulation formats (PAM-4, partial-response PAM-4, and PAM-8), two types of direct-detection receivers (APD- and SOA +++ PIN-based), and three digital reception strategies (unequalized, feed-forward equalized, and decision-feedback equalized). We evaluate by means of simulations the performance of these alternatives under different optoelectronics bandwidth and dispersion scenarios, identifying O-band feasible solutions able to reach 20 km of fiber and an optical path loss of at least 29 dB over a wide wavelength range of operation. Finally, we compare two digitally precompensated modulation schemes that are highly tolerant of chromatic dispersion, showing a possible extension to C-band operation, preserving direct-detection and linear-impairment equalization at the optical network unit side

    Proportion of various types of thyroid disorders among newborns with congenital hypothyroidism and normally located gland: A regional cohort study

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    Objective To determine the proportion of the various types of thyroid disorders among newborns detected by the neonatal TSH screening programme, with a normally located thyroid gland.Patients and methods Of the 882 575 infants screened in our centre between 1981 and 2002, 85 infants with a normally located gland had persistent elevation of serum TSH values (an incidence of 1/10 383). Six of these 85 patients were lost to follow-up and were therefore excluded from the study. During follow-up, patients were classified as having permanent or transient hypothyroidism.Results Among the 79 patients included in the study, transient (n = 30, 38% of cases) and permanent (n = 49, 62% of cases) congenital hypothyroidism (CH) was demonstrated during the follow-up at the age of 0.7 +/- 0.6 years and 2.6 +/- 1.8 years (P < 0.0001), respectively. The proportion of premature births was significantly higher in the group with transient CH (57%) than in the group with permanent CH (2%) (P < 0.0001). A history of iatrogenic iodine overload was identified during the neonatal period in 69% of transient cases. Among permanent CH cases (n = 49), patients were classified as having a goitre (n = 27, 55% of cases), a normal sized and shaped thyroid gland (n = 14, 29% of cases) or a hypoplastic gland (n = 8, 16% of cases). The latter patients demonstrated global thyroid hypoplasia (n = 3), a right hemithyroid (n = 2), hypoplasia of the left lobe (n = 2), or asymmetry in the location of the two lobes (n = 1). Patients with a normal sized and shaped thyroid gland showed a significantly less severe form of hypothyroidism than those with a goitre or a hypoplastic thyroid gland (P < 0.0002). Among permanent CH cases, those with a goitre (n = 27) had an iodine organification defect (n = 10), Pendred syndrome (n = 1), a defect of thyroglobulin synthesis (n = 8), or a defect of sodium iodine symporter (n = 1), and in seven patients no aetiology could be determined. Among permanent cases with a normal sized and shaped thyroid gland (n = 14), a specific aetiology was found in only one patient (pseudohypoparathyroidism) and two patients had Down's syndrome. Among those with a globally hypoplastic gland, a TSH receptor gene mutation was found in two patients.Conclusions A precise description of the phenotype can enhance our understanding of various forms of neonatal hypothyroidism as well as their prevalence and management. It also helps to identify cases of congenital hypothyroidism of unknown aetiology, which will need to be investigated in collaboration with molecular biologists
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