Clinicopathological features of 214 maxillary sinus pathologies. A ten-year single-centre retrospective clinical study

BACKGROUND: Diagnosis of maxillary sinus pathology must include the clinical radiological study (CRS) and histopathological analysis. The aim of this study is 1) to describe the clinicopathological features of maxillary sinus lesions, obtained successively in a single medical centre over the last 10 years and 2) to determine the sensitivity and specificity for the diagnosis of malignant lesions based exclusively on the CRS. METHODS: It is a single-centre observational retrospective clinical study on patients who attended the University Hospital Complex of Santiago de Compostela (CHUS) with sinus pathologies during the period of 2009-2019. RESULTS: The sample consisted of 133 men (62.1%) and 81 women (37.9%), with an average age of 46.9 years (SD = 18.8). In terms of frequency, the most frequent pathology was the unspecified sinusitis (44.4%), followed by polyps (18.2%), malignant tumours (9.8%), inverting papilloma (7.5%), fungal sinusitis (4.7%), cysts (3.7%), benign tumours (2.3%), mucocele (2.3%) and other lesions (1.9%). Cysts and benign tumours were diagnosed earliest Vs malignant tumours (65.2 years (SD = 16.1)) were diagnosed the latest (p < 0.001). Based only on the CRS for malignancies, diagnostic indexes were 71.4% sensitivity and 97.9% specificity, with a Kappa value of 0.68 with (p < 0.001). CONCLUSION: Maxillary sinus pathology is very varied with therapeutic and prognostic repercussions. CRS is sometimes insufficient and histopathological confirmation is essential

Search for the Lepton-Flavor-Violating Decays B-s(0) -> e(+/-)mu(-/+) and B-0 -> e(+/-)mu(-/+)

A search for the lepton-flavor-violating decays B0s\u2192e\ub1\u3bc 13 and B0\u2192e\ub1\u3bc 13 is performed with a data sample, corresponding to an integrated luminosity of 1.0\u2009\u2009fb 121 of pp collisions at s 1a=7\u2009\u2009TeV, collected by the LHCb experiment. The observed number of B0s\u2192e\ub1\u3bc 13 and B0\u2192e\ub1\u3bc 13 candidates is consistent with background expectations. Upper limits on the branching fractions of both decays are determined to be \u212c(B0s\u2192e\ub1\u3bc 13)<1.1(1.4) 710 128 and \u212c(B0\u2192e\ub1\u3bc 13)<2.8(3.7) 710 129 at 90% (95%) confidence level (C.L.). These limits are a factor of 20 lower than those set by previous experiments. Lower bounds on the Pati-Salam leptoquark masses are also calculated, MLQ(B0s\u2192e\ub1\u3bc 13)>101\u2009\u2009TeV/c2 and MLQ(B0\u2192e\ub1\u3bc 13)>126\u2009\u2009TeV/c2 at 95% C.L., and are a factor of 2 higher than the previous bounds