Accurate nine-decade temperature-compensated logarithmic amplifier

Transistor-driven temperature-stable amplifier with logarithmic operating characteristics permits presentation of the entire range of the reactor without range switching. This circuit is capable of monitoring ion chamber currents over spans of 8 or 9 decades and is used in nuclear reactor instrumentation. Application is found in materials under ultrahigh vacuum

Sickness certification system in the United Kingdom: qualitative study of views of general practitioners in Scotland

Objectives: To explore how general practitioners operate the sickness certification system, their views on the system, and suggestions for change. Design: Qualitative focus group study consisting of 11 focus groups with 67 participants. Setting: General practitioners in practices in Glasgow, Tayside, and Highland regions, Scotland. Sample: Purposive sample of general practitioners, with further theoretical sampling of key informant general practitioners to examine emerging themes. Results: General practitioners believed that the sickness certification system failed to address complex, chronic, or doubtful cases. They seemed to develop various operational strategies for its implementation. There appeared to be important deliberate misuse of the system by general practitioners, possibly related to conflicts about roles and incongruities in the system. The doctor-patient relationship was perceived to conflict with the current role of general practitioners in sickness certification. When making decisions about certification, the general practitioners considered a wide variety of factors. They experienced contradictory demands from other system stakeholders and felt blamed for failing to make impossible reconciliations. They clearly identified the difficulties of operating the system when there was no continuity of patient care. Many wished either to relinquish their gatekeeper role or to continue only with major changes. Conclusions: Policy makers need to recognise and accommodate the range and complexity of factors that influence the behaviour of general practitioners operating as gatekeepers to the sickness certification system, before making changes. Such changes are otherwise unlikely to result in improvement. Models other than the primary care gatekeeper model should be considered

Translating pharmacogenetics and pharmacogenomics to the clinic: progress in human and veterinary medicine

As targeted personalized therapy becomes more widely used in human medicine, clients will expect the veterinary clinician to be able to implement an evidence-based strategy regarding both the prescribing of medicines and also recognition of the potential for adverse drug reactions (ADR) for their pet, at breed and individual level. This review aims to provide an overview of current developments and challenges in pharmacogenetics in medicine for a veterinary audience and to map these to developments in veterinary pharmacogenetics. Pharmacogenetics has been in development over the past 100 years but has been revolutionized following the publication of the human, and then veterinary species genomes. Genetic biomarkers called pharmacogenes have been identified as specific genetic loci on chromosomes which are associated with either positive or adverse drug responses. Pharmacogene variation may be classified according to the associated drug response, such as a change in (1) the pharmacokinetics; (2) the pharmacodynamics; (3) genes in the downstream pathway of the drug or (4) the effect of “off-target” genes resulting in a response that is unrelated to the intended target. There are many barriers to translation of pharmacogenetic information to the clinic, however, in human medicine, international initiatives are promising real change in the delivery of personalized medicine by 2025. We argue that for effective translation into the veterinary clinic, clinicians, international experts, and stakeholders must collaborate to ensure quality assurance and genetic test validation so that animals may also benefit from this genomics revolution

Far Infrared Variability of Sagittarius A*: 25.5 Hours of Monitoring with HerschelHerschel

Variable emission from Sgr~A*, the luminous counterpart to the super-massive black hole at the center of our Galaxy, arises from the innermost portions of the accretion flow. Better characterization of the variability is important for constraining models of the low-luminosity accretion mode powering Sgr~A*, and could further our ability to use variable emission as a probe of the strong gravitational potential in the vicinity of the $4\times10^{6}\mathrm{M}_{\odot}$ black hole. We use the \textit{Herschel} Spectral and Photometric Imaging Receiver (SPIRE) to monitor Sgr~A* at wavelengths that are difficult or impossible to observe from the ground. We find highly significant variations at 0.25, 0.35, and 0.5 mm, with temporal structure that is highly correlated across these wavelengths. While the variations correspond to $<$1% changes in the total intensity in the \textit{Herschel} beam containing Sgr~A*, comparison to independent, simultaneous observations at 0.85 mm strongly supports the reality of the variations. The lowest point in the light curves, $\sim$0.5 Jy below the time-averaged flux density, places a lower bound on the emission of Sgr~A* at 0.25 mm, the first such constraint on the THz portion of the SED. The variability on few hour timescales in the SPIRE light curves is similar to that seen in historical 1.3 mm data, where the longest time series is available, but the distribution of variations in the sub-mm do not show a tail of large-amplitude variations seen at 1.3 mm. Simultaneous X-ray photometry from XMM-Newton shows no significant variation within our observing period, which may explain the lack of very large variations if X-ray and submillimeter flares are correlated.Comment: Accepted for publication in Ap

Deep Herschel view of obscured star formation in the Bullet cluster

We use deep, five band (100–500 μm) data from the Herschel Lensing Survey (HLS) to fully constrain the obscured star formation rate, SFR_(FIR), of galaxies in the Bullet cluster (z = 0.296), and a smaller background system (z = 0.35) in the same field. Herschel detects 23 Bullet cluster members with a total SFRFIR = 144±14 M_☉ yr^(-1). On average, the background system contains brighter far-infrared (FIR) galaxies, with ~50% higher SFRFIR (21 galaxies; 207 ± 9 M_☉ yr^(-1)). SFRs extrapolated from 24 μm flux via recent templates (SFR_(24 µm)) agree well with SFRFIR for ~60% of the cluster galaxies. In the remaining ~40%, SFR24 µm underestimates SFR_(FIR) due to a significant excess in observed S_(100)/S_(24) (rest frame S_(75)/S_(18)) compared to templates of the same FIR luminosity

Geospatial analysis of regional climate impacts to accelerate cost-efficient direct air capture deployment

Carbon dioxide (CO2) removal from the atmospheric will be essential if we are to achieve net-zero emissions targets. Direct air capture (DAC) is a CO2 removal method with the potential for large-scale deployment. However, DAC operational costs, and thus deployment potential, is dependent on performance, which can vary under different climate conditions. Here, to further develop our understanding of the impact of regional climate variation on DAC performance, we use high-resolution hourly based global weather profiles between 2016 and 2020 and weighted average capital costs to obtain DAC regional performance and levelized cost of DAC (LCOD). We found that relatively cold and drier regions have favorable DAC performance. Moreover, approximately 25% of the world’s land is potentially unsuitable due to very cold ambient temperatures for a substantial part of the year. For the remaining regions, the estimated LCOD is $320–$540 per tCO2 at an electricity cost of $50 MWh−1. Our results improve the understanding of regional DAC performance, which can provide valuable insights for sustainable DAC deployment and effective climate action

Beyond 90% capture: Possible, but at what cost?

© 2020 Elsevier Ltd Carbon capture and storage (CCS) will have an essential role in meeting our climate change mitigation targets. CCS technologies are technically mature and will likely be deployed to decarbonise power, industry, heat, and removal of CO2 from the atmosphere. The assumption of a 90% CO2 capture rate has become ubiquitous in the literature, which has led to doubt around whether CO2 capture rates above 90% are even feasible. However, in the context of a 1.5 °C target, going beyond 90% capture will be vital, with residual emissions needing to be indirectly captured via carbon dioxide removal (CDR) technologies. Whilst there will be trade-offs between the cost of increased rates of CO2 capture, and the cost of offsets, understanding where this lies is key to minimising the dependence on CDR. This study quantifies the maximum limit of feasible CO2 capture rate for a range of power and industrial sources of CO2, beyond which abatement becomes uneconomical. In no case, was a capture rate of 90% found to be optimal, with capture rates of up to 98% possible at a relatively low marginal cost. Flue gas composition was found to be a key determinant of the cost of capture, with more dilute streams exhibiting a more pronounced minimum. Indirect capture by deploying complementary CDR is also assessed. The results show that current policy initiatives are unlikely to be sufficient to enable the economically viable deployment of CCS in all but a very few niche sectors of the economy