Sp(2)-Symmetric Lagrangian BRST Quantization

One Lagrangian BRST quantization principle is that of imposing correct Schwinger-Dyson equations through the BRST Ward identities. In this paper we show how to derive the analogous $Sp(2)$-symmetric quantization condition in flat coordinates from an underlying $Sp(2)$-symmetric Schwinger-Dyson BRST symmetry. We also show under what conditions this can be recast in the language of triplectic quantization.Comment: LaTeX, 19 page

BRST Gauge Fixing and Regularization

In the presence of consistent regulators, the standard procedure of BRST gauge fixing (or moving from one gauge to another) can require non-trivial modifications. These modifications occur at the quantum level, and gauges exist which are only well-defined when quantum mechanical modifications are correctly taken into account. We illustrate how this phenomenon manifests itself in the solvable case of two-dimensional bosonization in the path-integral formalism. As a by-product, we show how to derive smooth bosonization in Batalin-Vilkovisky Lagrangian BRST quantization.Comment: LaTeX, 12 page

Redefining B-twisted topological sigma models

A recently proposed variation on the usual procedure to perform the topological B-twist in rigid $N=2$ models is applied to the case of the $\sigma$ model on a K\"ahler manifold. This leads to an alternative description of Witten's topological $\sigma$ model, which allows for a proper BRST interpretation and ghost number assignement. We also show that the auxiliary fields, which are responsible for the off shell closure of the $N=2$ algebra, play an important role in our construction.Comment: one reference adde

The regularized BRST Jacobian of pure Yang-Mills theory

The Jacobian for infinitesimal BRST transformations of path integrals for pure Yang-Mills theory, viewed as a matrix \unity +\Delta J in the space of Yang-Mills fields and (anti)ghosts, contains off-diagonal terms. Naively, the trace of $\Delta J$ vanishes, being proportional to the trace of the structure constants. However, the consistent regulator \cR, constructed from a general method, also contains off-diagonal terms. An explicit computation demonstrates that the regularized Jacobian Tr\ \Delta J\exp -\cR /M^2 for $M^2\rightarrow \infty$ is the variation of a local counterterm, which we give. This is a direct proof at the level of path integrals that there is no BRST anomaly.Comment: 12 pages, latex, CERN-TH.6541/92, KUL-TF-92/2

An alternative BRST operator for topological Landau-Ginzburg models

We propose a new BRST operator for the B-twist of N=2 Landau-Ginzburg (LG) models. It solves the problem of the fractional ghost numbers of Vafa's old BRST operator and shows how the model is obtained by gauge fixing a zero action. An essential role is played by the anti-BRST operator,which is given by one of the supersymmetries of the N=2 algebra. Its presence is needed in proving that the model is indeed a topological field theory. The space of physical observables, defined by taking the anti-BRST cohomology in the BRST cohomology groups, is unchanged

Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy

Distal hereditary motor neuropathies are a rare subgroup of inherited peripheral neuropathies hallmarked by a length-dependent axonal degeneration of lower motor neurons without significant involvement of sensory neurons. We identified patients with heterozygous nonsense mutations in the alpha II-spectrin gene, SPTAN1, in three separate dominant hereditary motor neuropathy families via next-generation sequencing. Variable penetrance was noted for these mutations in two of three families, and phenotype severity differs greatly between patients. The mutant mRNA containing nonsense mutations is broken down by nonsense-mediated decay and leads to reduced protein levels in patient cells. Previously, dominant-negative alpha II-spectrin gene mutations were described as causal in a spectrum of epilepsy phenotypes

Multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation : a tale of the unexpected

ObjectiveTo assess the clinical, radiologic, myopathologic, and proteomic findings in a patient manifesting a multisystem proteinopathy due to a homozygous valosin-containing protein gene (VCP) mutation previously reported to be pathogenic in the heterozygous state.MethodsWe studied a 36-year-old male index patient and his father, both presenting with progressive limb-girdle weakness. Muscle involvement was assessed by MRI and muscle biopsies. We performed whole-exome sequencing and Sanger sequencing for segregation analysis of the identified p.Arg159His VCP mutation. To dissect biological disease signatures, we applied state-of-the-art quantitative proteomics on muscle tissue of the index case, his father, 3 additional patients with VCP-related myopathy, and 3 control individuals.ResultsThe index patient, homozygous for the known p.Arg159His mutation in VCP, manifested a typical VCP-related myopathy phenotype, although with a markedly high creatine kinase value and a relatively early disease onset, and Paget disease of bone. The father exhibited a myopathy phenotype and discrete parkinsonism, and multiple deceased family members on the maternal side of the pedigree displayed a dementia, parkinsonism, or myopathy phenotype. Bioinformatic analysis of quantitative proteomic data revealed the degenerative nature of the disease, with evidence suggesting selective failure of muscle regeneration and stress granule dyshomeostasis.ConclusionWe report a patient showing a multisystem proteinopathy due to a homozygous VCP mutation. The patient manifests a severe phenotype, yet fundamental disease characteristics are preserved. Proteomic findings provide further insights into VCP-related pathomechanisms

Conformal and Superconformal Mechanics

We investigate the conformal and superconformal properties of a non-relativistic spinning particle propagating in a curved background coupled to a magnetic field and with a scalar potential. We derive the conditions on the couplings for a large class of such systems which are necessary in order their actions admit conformal and superconformal symmetry. We find that some of these conditions can be encoded in the conformal and holomorphic geometry of the background. Several new examples of conformal and superconformal models are also given.Comment: 46 pages, Phyzzx.te

Integrable Schr\"odinger operators with magnetic fields: factorisation method on curved surfaces

The factorisation method for Schr\"odinger operators with magnetic fields on a two-dimensional surface $M^2$ with non-trivial metric is investigated. This leads to the new integrable examples of such operators and brings a new look at some classical problems such as Dirac magnetic monopole and Landau problem. The global geometric aspects and related spectral properties of the operators from the factorisation chains are discussed in details. We also consider the Laplace transformations on a curved surface and extend the class of Schr\"odinger operators with two integrable levels introduced in the flat case by S.P.Novikov and one of the authors.Comment: 20 page

Global Anomalies in the Batalin Vilkovisky Quantization

The Batalin Vilkovisky (BV) quantization provides a general procedure for calculating anomalies associated to gauge symmetries. Recent results show that even higher loop order contributions can be calculated by introducing an appropriate regularization-renormalization scheme. However, in its standard form, the BV quantization is not sensible to quantum violations of the classical conservation of Noether currents, the so called global anomalies. We show here that the BV field antifield method can be extended in such a way that the Ward identities involving divergencies of global Abelian currents can be calculated from the generating functional, a result that would not be obtained by just associating constant ghosts to global symmetries. This extension, consisting of trivially gauging the global Abelian symmetries, poses no extra obstruction to the solution of the master equation, as it happens in the case of gauge anomalies. We illustrate the procedure with the axial model and also calculating the Adler Bell Jackiw anomaly.Comment: We emphasized the fact that our procedure only works for the case of Abelian global anomalies. Section 3 was rewritten and some references were added. 12 pages, LATEX. Revised version that will appear in Phys. Rev.