Epigenetic regulation of caloric restriction in aging

The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently affected by environmental factors, and caloric restriction is by far the most effective and established environmental manipulation for extending lifespan in various animal models. However, the precise mechanisms by which caloric restriction affects lifespan are still not clear. Epigenetic mechanisms have recently been recognized as major contributors to nutrition-related longevity and aging control. Two primary epigenetic codes, DNA methylation and histone modification, are believed to dynamically influence chromatin structure, resulting in expression changes of relevant genes. In this review, we assess the current advances in epigenetic regulation in response to caloric restriction and how this affects cellular senescence, aging and potential extension of a healthy lifespan in humans. Enhanced understanding of the important role of epigenetics in the control of the aging process through caloric restriction may lead to clinical advances in the prevention and therapy of human aging-associated diseases

Problems encountered by radiologic technologist in handling elderly patients in selected hospitals in Cavite

The descriptive method was employed in this study. Self-made questionnaire was used in data gathering. One hundred fifty one (151) radiologic technologists participated in the study using purposive sampling. In the analysis of data, mean, standard deviation, frequency distribution, percentage and ANOVA were used. The study revealed that majority of the respondents belong to 25 years old and below and work at De La Salle University Medical Center. Problems in handling elderly patients in terms of physical capabilities were slowed mobility from wheelchair and stretcher to x-ray table , can no longer hold/maintain proper body position or part position and breathing , slowed reaction in positioning and problems with disabled or partially abled patients . In terms of communication, problems were diminished sense of hearing and visualization and difficulty in following, understanding and not paying attention to the instructions. This means that almost half of the identified problems are encountered by the respondents to a great extent. The problems encountered by the respondents do not vary when grouped according to age but vary according to their hospital affiliation. Hospitals have different policies and protocol pertaining to handling elderly patients which may be the cause of the problems encountered