The Challenge of Climate Change Adaptation for Agriculture: an Economically Oriented Review

Climate change is occurring. Deviations from historic temperatures and precipitation plus increased frequency of extreme events are modifying agriculture systems globally. Adapting agricultural management practices offers a way to lessen the effects or exploit opportunities. Herein many aspects of the adaptation issue are discussed, including needs, strategies, observed actions, benefits, economic analysis approaches, role of public/private actors, limits, and project evaluation. We comment on the benefits and shortcomings of analytical methods and suggested economic efforts. Economists need to play a role in such diverse matters as projecting adaptation needs, designing adaptation incentives, and evaluating projects to ensure efficiency and effectiveness

Low Mass Stars and Substellar Objects in the NGC 1333 Molecular Cloud

We present the results of near-infrared imaging and low-resolution near- infrared spectroscopy of low mass objects in the NGC 1333 molecular cloud. A JHK survey of an 11.4' x 11.7' area of the northern cluster was conducted to a sensitivity of K < 16 mag. Using near-infrared magnitudes and colors from this and previously published surveys, twenty-five brown dwarf candidates were selected toward the high extinction cloud core. Spectra in the K band were obtained and comparisons of the depths of water vapor absorption bands in our candidate objects with a grid of dwarf,subgiant, and giant standards were made to derive spectral types. These data were then used to derive effective temperatures and stellar luminosities which, when combined with theoretical tracks and isochrones for pre-main sequence objects, resulted in estimates for their masses and ages. The models suggest a median age for the sample of < 1 Myr with substellar masses for at least 9 of the candidates including the x-ray flare source ASR 24. Surface gravities have been estimated for the brown dwarf candidates and, for a given spectral type,found to resemble more closely dwarfs than giants. Using the near-infrared imaging data and age estimates from the spectroscopic sample, an extinction-limited sample in the northern cluster was defined. Consistent with recent studies of other young clusters, this sample exhibits an accretion disk frequency of 0.75 +-0.20 and a mass spectrum slope across the hydrogen-burning limit of alpha < 1.6 where dN/dM ~ M^-(alpha).Comment: 22 postscript pages, 12 postscript figures, and 3 postscript tables. Accepted for publication in the Astronomical Journal (February, 2004

Solar Flare Intermittency and the Earth's Temperature Anomalies

We argue that earth's short-term temperature anomalies and the solar flare intermittency are linked. The analysis is based upon the study of the scaling of both the spreading and the entropy of the diffusion generated by the fluctuations of the temperature time series. The joint use of these two methods evidences the presence of a L\'{e}vy component in the temporal persistence of the temperature data sets that corresponds to the one that would be induced by the solar flare intermittency. The mean monthly temperature datasets cover the period from 1856 to 2002.Comment: 4 pages, 5 figure

Bcl11b—A Critical Neurodevelopmental Transcription Factor—Roles in Health and Disease

B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. It works as both a genetic suppressor and activator, acting directly, attaching to promoter regions, as well as indirectly, attaching to promoter-bound transcription factors. Bcl11b is a fundamental transcription factor in fetal development, with important roles for the differentiation and development of various neuronal subtypes in the central nervous system (CNS). It has been used as a specific marker of layer V subcerebral projection neurons as well as striatal interneurons. Bcl11b also has critical developmental functions in the immune, integumentary and cardiac systems, to the extent that Bcl11b knockout mice are incompatible with extra-uterine life. Bcl11b has been implicated in a number of disease states including Huntington’s disease, Alzheimer’s disease, HIV and T-Cell malignancy, amongst others. Bcl11b is a fascinating protein whose critical roles in the CNS and other parts of the body are yet to be fully explicated. This review summarizes the current literature on Bcl11b and its functions in development, health, and disease as well as future directions for research

Would Functional Agricultural Foods Improve Human Health?

Concern over diet-health relationships has moved to the forefront of public health concerns in the UK and much of the developed world. It has been estimated, for example, that obesity costs the UK National Health Service up to £6b per year (Rayner and Scarborough, 2005), but if all consumers were to follow recommended healthy eating guidelines there would be major implications for food consumption, land use and international trade (Srinivasan et al, 2006). This is unlikely to happen, at least in the short term, but it is realistic to anticipate some dietary adjustment toward the recommendations, resulting in an improvement in diet quality (Mazzocchi et al, 2007). Although consumers are reluctant to make major changes to their diets, they may be prepared to substitute existing foods for healthier alternatives. Three of the most prominent nutritional recommendations are to consume more fruit and vegetables, which contain phytochemicals beneficial to health, reduce consumption of saturated fatty acids (SFA) and increase intake of long-chain n-3 fatty acids (FA). In the first case, consumption of fruit and vegetables has been stable at around three 80 g portions per person per day according to the Health Survey for England. It is estimated that 42,200 deaths per year could be avoided in England and 411,000 Quality Adjusted Life Years (QALYs) could be saved if fruit and vegetable consumption were increased to the recommended 5 portions per day (Ofcom 2006). As well as continuing to encourage people to eat more, it could be desirable to ‘intensify’ the beneficial phytochemical content of existing fruit and vegetables.Agribusiness, Agricultural and Food Policy, Farm Management, Food Consumption/Nutrition/Food Safety, Industrial Organization,

Spectroscopy of Brown Dwarf Candidates in the rho Ophiuchi Molecular Core

We present an analysis of low resolution infrared spectra for 20 brown dwarf candidates in the core of the $\rho$ Ophiuchi molecular cloud. Fifteen of the sources display absorption-line spectra characteristic of late-type stars. By comparing the depths of water vapor absorption bands in our candidate objects with a grid of M dwarf standards, we derive spectral types which are independent of reddening. Optical spectroscopy of one brown dwarf candidate confirms the spectral type derived from the water bands. Combining their spectral types with published near-infrared photometry, effective temperatures and bolometric stellar luminosities are derived enabling us to place our sample on the Hertzsprung-Russell diagram. We compare the positions of the brown dwarf candidates in this diagram with two sets of theoretical models in order to estimate their masses and ages. Considering uncertainties in placing the candidates in the H-R diagram, six objects consistently lie in the brown dwarf regime and another five objects lie in the transition region between stellar and substellar objects. The ages inferred for the sample are consistent with those derived for higher mass association members. Three of the newly identified brown dwarfs display infrared excesses at $\lambda$=2.2 $\mu$m suggesting that young brown dwarfs can have active accretion disks. Comparing our mass estimates of the brown dwarf candidates with those derived from photometric data alone suggests that spectroscopy is an essential component of investigations of the mass functions of young clusters.Comment: Astronomical Journal, in press: 25 pages, latex, 5 tables and 6 figures (separate

Predictors and outcomes of crossover to surgery from physical therapy for meniscal tear and osteoarthritis a randomized trial comparing physical therapy and surgery

BACKGROUND: Arthroscopic partial meniscectomy (APM) combined with physical therapy (PT) have yielded pain relief similar to that provided by PT alone in randomized trials of subjects with a degenerative meniscal tear. However, many patients randomized to PT received APM before assessment of the primary outcome. We sought to identify factors associated with crossing over to APM and to compare pain relief between patients who had crossed over to APM and those who had been randomized to APM. METHODS: We used data from the MeTeOR (Meniscal Tear in Osteoarthritis Research) Trial of APM with PT versus PT alone in subjects ≥45 years old who had mild-to-moderate osteoarthritis and a degenerative meniscal tear. We assessed independent predictors of crossover to APM among those randomized to PT. We also compared pain relief at 6 months among those randomized to PT who crossed over to APM, those who did not cross over, and those originally randomized to APM. RESULTS: One hundred and sixty-four subjects were randomized to and received APM and 177 were randomized to PT, of whom 48 (27%) crossed over to receive APM in the first 140 days after randomization. In multivariate analyses, factors associated with a higher likelihood of crossing over to APM among those who had originally been randomized to PT included a baseline Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Score of ≥40 (risk ratio [RR] = 1.99; 95% confidence interval [CI] = 1.00, 3.93) and symptom duration of <1 year (RR = 1.74; 95% CI = 0.98, 3.08). Eighty-one percent of subjects who crossed over to APM and 82% of those randomized to APM had an improvement of ≥10 points in their pain score at 6 months, as did 73% of those who were randomized to and received only PT. CONCLUSIONS: Subjects who crossed over to APM had presented with a shorter symptom duration and greater baseline pain than those who did not cross over from PT. Subjects who crossed over had rates of surgical success similar to those of the patients who had been randomized to surgery. Our findings also suggest that an initial course of rigorous PT prior to APM may not compromise surgical outcome. LEVEL OF EVIDENCE: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence

Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: a prospective cohort study

Background: Patients undergoing radical cystectomy have associated comorbidities resulting in reduced cardiorespiratory fitness. Preoperative cardiopulmonary exercise testing (CPET) measures including anaerobic threshold (AT) can predict major adverse events (MAE) and hospital length of stay (LOS) for patients undergoing open and robotic cystectomy with extracorporeal diversion. Our objective was to determine the relationship between CPET measures and outcome in patients undergoing robotic radical cystectomy and intracorporeal diversion (intracorporeal robotic assisted radical cystectomy [iRARC]). Methods: A single institution prospective cohort study in patients undergoing iRARC for muscle invasive and high-grade bladder cancer. Inclusion: patients undergoing standardised CPET before iRARC. Exclusions: patients not consenting to data collection. Data on CPET measures (AT, ventilatory equivalent for carbon dioxide [VE/VCO2] at AT, peak oxygen uptake [VO2]), and patient demographics prospectively collected. Outcome measurements included hospital LOS; 30-day MAE and 90-day mortality data, which were prospectively recorded. Descriptive and regression analyses were used to assess whether CPET measures were associated with or predicted outcomes. Results: From June 2011 to March 2015, 128 patients underwent radical cystectomy (open cystectomy, n = 17; iRARC, n = 111). A total of 82 patients who underwent iRARC and CPET and consented to participation were included. Median (interquartile range): age = 65 (58–73); body mass index = 27 (23–30); AT = 10.0 (9–11), Peak VO2 = 15.0 (13–18.5), VE/VCO2 (AT) = 33.0 (30–38). 30-day MAE = 14/111 (12.6%): death = 2, multiorgan failure = 2, abscess = 2, gastrointestinal = 2, renal = 6; 90-day mortality = 3/111 (2.7%). AT, peak VO2, and VE/VCO2 (at AT) were not significant predictors of 30-day MAE or LOS. The results are limited by the absence of control group undergoing open surgery. Conclusions: Poor cardiorespiratory fitness does not predict increased hospital LOS or MAEs in patients undergoing iRARC. Overall, MAE and LOS comparable with other series

Central heating settings in low energy social housing in the United Kingdom

This paper presents essential empirical data on heating setpoint temperatures and durations from UK social housing built to low energy standards. The data was derived from living room air temperature measurements. There were single, double and multiple heating periods per day in the dwellings with mean setpoint temperatures of 20.9°C and 21.0°C on weekdays and weekends respectively. The weekday mean heating duration was 8.4 hours and for weekends, it was 9.1 hours. The results could be used to better inform the assumptions of space heating behaviour used in energy models in order to more accurately predict the space heating energy demands of dwellings