665 research outputs found
Heteropolymer Sequence Design and Preferential Solvation of Hydrophilic Monomers: One More Application of Random Energy Model
In this paper, we study the role of surface of the globule and the role of
interactions with the solvent for designed sequence heteropolymers using random
energy model (REM). We investigate the ground state energy and surface monomer
composition distribution. By comparing the freezing transition in random and
designed sequence heteropolymers, we discuss the effects of design. Based on
our results, we are able to show under which conditions solvation effect
improves the quality of sequence design. Finally, we study sequence space
entropy and discuss the number of available sequences as a function of imposed
requirements for the design quality
Ultra Luminous X-ray sources - new distance indicators?
In this paper we fit the NuSTAR and XMM-Newton data of three sources:
NGC7793~P13, NGC5907~ULX1, and Circinus~ULX5. Our single model contains
emission form non-spherical system: neutron star plus accretion disk directed
towards observer. We obtained the very good fit with the reduced per
degree of freedom equal 1.08 for P13, 1.01 for ULX1, and 1.14 for ULX5.The
normalization of our model constrains the distance to the source. The resulting
distances are , and
~Mpc for P13, ULX1 and ULX5 respectively. The distances
to P13 and ULX5 are in perfect agreement with previous distance measurements to
their host galaxies. Our results confirm that P13, ULX1 and ULX5 may contain
central hot neutron star. When the outgoing emission is computed by integration
over the emitting surface and successfully fitted to the data, then the
resulting model normalization is the direct distance indicator.Comment: 5 pages, 3 figures, accepted for publication in A&A Letter
On the poverty of a priorism: technology, surveillance in the workplace and employee responses
Many debates about surveillance at work are framed by a set of a priori assumptions about the nature of the employment relationship that inhibits efforts to understand the complexity of employee responses to the spread of new technology at work. In particular, the debate about the prevalence of resistance is hamstrung from the outset by the assumption that all apparently non-compliant acts, whether intentional or not, are to be counted as acts of resistance. Against this background this paper seeks to redress the balance by reviewing results from an ethnographic study of surveillance-capable technologies in a number of British workplaces. It argues for greater attention to be paid to the empirical character of the social relations at work in and through which technologies are deployed and in the context of which employee responses are played out
Two-photon spin injection in semiconductors
A comparison is made between the degree of spin polarization of electrons
excited by one- and two-photon absorption of circularly polarized light in bulk
zincblende semiconductors. Time- and polarization-resolved experiments in
(001)-oriented GaAs reveal an initial degree of spin polarization of 49% for
both one- and two-photon spin injection at wavelengths of 775 and 1550 nm, in
agreement with theory. The macroscopic symmetry and microscopic theory for
two-photon spin injection are reviewed, and the latter is generalized to
account for spin-splitting of the bands. The degree of spin polarization of
one- and two-photon optical orientation need not be equal, as shown by
calculations of spectra for GaAs, InP, GaSb, InSb, and ZnSe using a 14x14 k.p
Hamiltonian including remote band effects. By including the higher conduction
bands in the calculation, cubic anisotropy and the role of allowed-allowed
transitions can be investigated. The allowed-allowed transitions do not
conserve angular momentum and can cause a high degree of spin polarization
close to the band edge; a value of 78% is calculated in GaSb, but by varying
the material parameters it could be as high as 100%. The selection rules for
spin injection from allowed-allowed transitions are presented, and interband
spin-orbit coupling is found to play an important role.Comment: 12 pages including 7 figure
Safe and complete contig assembly via omnitigs
Contig assembly is the first stage that most assemblers solve when
reconstructing a genome from a set of reads. Its output consists of contigs --
a set of strings that are promised to appear in any genome that could have
generated the reads. From the introduction of contigs 20 years ago, assemblers
have tried to obtain longer and longer contigs, but the following question was
never solved: given a genome graph (e.g. a de Bruijn, or a string graph),
what are all the strings that can be safely reported from as contigs? In
this paper we finally answer this question, and also give a polynomial time
algorithm to find them. Our experiments show that these strings, which we call
omnitigs, are 66% to 82% longer on average than the popular unitigs, and 29% of
dbSNP locations have more neighbors in omnitigs than in unitigs.Comment: Full version of the paper in the proceedings of RECOMB 201
Postmortem examination of patient H.M.ās brain based on histological sectioning and digital 3D reconstruction
Modern scientific knowledge of how memory functions are organized in the human brain originated from the case of Henry G. Molaison (H.M.), an epileptic patient whose amnesia ensued unexpectedly following a bilateral surgical ablation of medial temporal lobe structures, including the hippocampus. The neuroanatomical extent of the 1953 operation could not be assessed definitively during H.M.ās life. Here we describe the results of a procedure designed to reconstruct a microscopic anatomical model of the whole brain and conduct detailed 3D measurements in the medial temporal lobe region. This approach, combined with cellular-level imaging of stained histological slices, demonstrates a significant amount of residual hippocampal tissue with distinctive cytoarchitecture. Our study also reveals diffuse pathology in the deep white matter and a small, circumscribed lesion in the left orbitofrontal cortex. The findings constitute new evidence that may help elucidate the consequences of H.M.ās operation in the context of the brainās overall pathology
Improving teaching: Enhancing ways of being university teachers
My aim in this paper is to theorize my teaching in a course for experienced university teachers, in a context of increased attention to such courses. My focus in the course is transforming and enhancing ways of being university teachers, through integrating knowing, acting and being. In other words, epistemology is not seen as an end in itself, but rather it is in the service of ontology. In the paper, I explore and illustrate how this focus on ontology is enacted in the course
Massive multiplication of genome and ribosomes in dormant cells (akinetes) of Aphanizomenon ovalisporum (Cyanobacteria)
Author Posting. Ā© The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in The ISME Journal 6 (2012): 670ā679, doi:10.1038/ismej.2011.128.Akinetes are dormancy cells commonly found among filamentous cyanobacteria, many of which are toxic and/or nuisance, bloom-forming species. Development of akinetes from vegetative cells is a process that involves morphological and biochemical modifications. Here we applied a single cell approach to quantify genome and ribosome content of akinetes and vegetative cells in Aphanizomenon ovalisporum (Cyanobacteria). Vegetative cells of A. ovalisporum were naturally polyploid and contained on average 8 genome copies per cell. However, the chromosomal content of akinetes increased up to 450 copies, with an average value of 119 genome copies per akinete, 15 fold higher that in vegetative cells. Based on fluorescence in situ hybridization with a probe targeting 16S rRNA and detection with confocal laser scanning microscopy we conclude that ribosomes accumulated in akinetes to a higher level than that found in vegetative cells. We further present evidence that this massive accumulation of nucleic acids in akinetes is likely supported by phosphate supplied from inorganic polyphosphate bodies that were abundantly present in vegetative cells, but notably absent from akinetes. These results are interpreted in the context of cellular investments for proliferation following long term dormancy, as the high nucleic acid content would provide the basis for extended survival, rapid resumption of metabolic activity and cell division upon germination.Supported by the Gruss Lipper Foundation research award (AS). This study was part of the Joint German-Israeli-Project (FKZ 02WT0985, WR803) funded by the German Ministry of Research and Technology (BMBF) and Israel Ministry of Science and Technology (MOST)
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