Modeling data entry and operations in WebML

Web Modeling Language (WebML, http://webml.org) is a notation for visually specifying complex Web sites at the conceptual level. All the concepts of WebML are specified both graphically and in XML; in particular, navigation and composition abstractions are based on a restricted number of hypertext components (units) which are assembled into pages and interconnected by links. During implementation, pages and units are automatically translated into server-side scripting templates, which enable the display of data dynamically retrieved from heterogeneous data sources. This paper extends WebML with data entry and operation units, for gathering information from clients and invoking arbitrary operations. Predefined operations are also proposed as built-in primitives for supporting standard updates on the content of the underlying data sources (represented as entities and relationships). This natural extension of WebML permits the visual modeling of Web pages integrating read and write acces..

Model-driven design of service-enabled web applications

Significant efforts are currently invested in application integration to enable the interaction and composition of business processes of different companies, yielding complex, multi-party processes. Web service standards, based on WSDL, have been adopted as a process-to-process communication paradigm. This paper presents an industrial experience in integrating data-intensive and process-intensive Web applications through Web services. Design of sites and of Web services interaction exploits modern Web engineering methods, including conceptual modeling, model verification, visual data marshalling and automatic code generation. In particular, the applied method is based on a declarative model for specifying data-intensive Web applications that enact complex interactions, driven by the user, with remote processes implemented as services. We describe the internal architecture of the CASE tool that has been used, and give an overview of three industrial applications developed with the described approach. 1

A Framework for the Simulation of Web Applications

In recent years numerous Web application modeling languages have been developed and others improved. There has, however, been little research on how these languages may be simulated. Simulation of models constructed using design languages allows early evaluation and prevents unnecessary Web code development and implementation. It can therefore significantly reduce the design cycle time and cost. This paper introduces a Web application simulation model framework that was designed to be compatible with existing modeling languages. This was accomplished by specifically identifying the objectives of a simulation language and contrasting this with those of design models. The simulation model supports analysis of simulations from four key Web application perspectives (and hence the model is constructed around these perspectives) namely: presentation, navigation, functionality and content. We argue that with this approach substantial inferences about the quality of the design can be drawn from simulation of the Web application model

In Vitro and In Vivo Enzyme-Mediated Biomineralization of Oligo(poly(ethylene glycol) Fumarate Hydrogels

Item does not contain fulltextThe enzyme alkaline phosphatase (ALP) is added at different concentrations (i.e., 0, 2.5, and 10 mg ml(-1) ) to oligo(poly(ethylene glycol)fumarate) (OPF) hydrogels. The scaffolds are either incubated in 10 mM calcium glycerophosphate (Ca-GP) solution for 2 weeks or implanted in a rat subcutaneous model for 4 weeks. Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and alizarin red staining show a strong ability to form minerals exclusively in ALP-containing hydrogels in vitro. Additionally, the calcium content increases with increasing ALP concentration. Similarly, only ALP-containing hydrogels induce mineralization in vivo. Specifically, small ( approximately 5-20 microm) mineral deposits are observed at the periphery of the hydrogels near the dermis/scaffold interface using Von Kossa and alizarin red staining