Results for a turbulent system with unbounded viscosities: weak formulations, existence of solutions, boundedness, smoothness'

We consider a circulation system arising in turbulence modelling in fluid dynamics with unbounded eddy viscosities. Various notions of weak solutions are considered and compared. We establish existence and regularity results. In particular we study the boundedness of weak solutions. We also establish an existence result for a classical solutio

The prognostic value of stromal and epithelial periostin expression in human breast cancer: Correlation with clinical pathological features and mortality outcome

open6noBackground: PN is a secreted cell adhesion protein critical for carcinogenesis. In breast cancer, it is overexpressed compared to normal breast, and a few reports suggest that it has a potential role as a prognostic marker. Methods: Tumour samples obtained at the time of mastectomy from 200 women followed for a median time of 18.7 years (range 0.5-29.5 years) were investigated through IHC with a polyclonal anti-PN antibody using tissue microarrays. Epithelial and stromal PN expression were scored independently according to the percentage of coloured cells; the 60th percentile of PN epithelial expression, corresponding to 1 %, and the median value of PN stromal expression, corresponding to 90 %, were used as arbitrary cut-offs. The relationships between epithelial and stromal PN expression and clinicalpathological features, tumour phenotype and the risk of mortality following surgery were analysed. Appropriate statistics, including the Fine and Gray competing risk proportional hazard regression model, were used. Results: The expression of PN in tumour epithelial cells was significantly lower than that which was observed in stromal cells (p < 0.000). No specific association between epithelial or stromal PN expression and any of the clinicalpathological parameters analysed was found as it was observed in respect to mortality when these variables were analysed individually. However, when both variables were considered as a function of the other one, the expression of PN in the stromal cells maintained a statistically significant predictive value with respect to both all causes and cancerspecific mortality only in the presence of high epithelial expression levels. No significant differences in either all causes or BCa-specific mortality rates were shown according to epithelial expression for tumours displaying higher stromal PN expression rates. However, the trends were opposite for the higher stromal values and the patients with high epithelial expression levels denoted the group with the worst prognosis, while higher epithelial values in patients with lower stromal expression levels denoted the group with the best prognosis, suggesting that PN epithelial/stromal interactions play a crucial role in breast carcinogenesis, most likely due to functional cross-talk between the two compartments. On the basis of PN expression in both compartments, we defined 4 subgroups of patients with different mortality rates with the group of patients characterized by positive epithelial and low stromal PN expression cells showing the lowest mortality risk as opposed to the groups of patients identified by a high PN expression in both cell compartments or those identified by a low or absent PN expression in both cell compartments showing the worst mortality rates. The differences were highly statistically significant and were also retained after multiparametric analysis. Competing risk analysis demonstrated that PN expression patterns characterizing each of previous groups are specifically associated with cancer-specific mortality. Conclusions: Although they require further validation through larger studies, our findings suggest that the patterns of expression of PN in both compartments can allow for the development of IHC "signatures" that maintain a strong independent predictive value of both all causes and, namely, of cancer-specific mortality.openNuzzo, P.V.; Rubagotti, A.; Zinoli, L.; Salvi, S.; Boccardo, S.; Boccardo, F.Nuzzo, PIER VITALE; Rubagotti, Alessandra; Zinoli, Linda; Salvi, Sara; Boccardo, S.; Boccardo, F

Road network comparison and matching techniques. a workflow proposal for the integration of traffic message channel and open source network datasets

The rapid growth of methods and techniques to acquire geospatial data has led to a wide availability of overlapping geographic datasets with different characteristics. Road network data sources are today a significant number, with high differences in level of detail and modelling schemas, depending on the main purpose. In addition, continuous information about people and freight movement is today available also in real-time. This type of data is today exchanged between traffic operators using referencing standards as Traffic Message Channel. Integrating these heterogeneous databases, in order to build an added value product, is a serious task in geographical data management. The paper is focus on techniques to conflate the Traffic message Channel logical network on Open Source road network dataset, in order to allow the precise visualisation of traffic data also in real-time. A first step of the research was the quality assessment of available Open Source (OS) road network dataset, then, a specific procedure to conflate data was set up, using an iterative process in order to reduce at every step the number of possible matching features. A first application of the enhanced OTM dataset is shown for the city of Turin: real-time open data of traffic flows recorded by road network fixed sensors, made available by the metropolitan Traffic Operation Centre (5T) and based on the TMC location referencing, are matched on the OTM road network, allowing a detailed real-time visualisation of traffic state

DEFINITION OF A METHODOLOGY TO DERIVE ROAD NETWORK FUNCTIONAL HIERARCHY CLASSES USING CAR TRACKING DATA

Road network functional hierarchy classifies individual roads into several levels, for efficient traffic management and road network generalization purposes. Automatic and semi-automatic road network extraction methods exist, but the generated products normally lack information on its functional hierarchy. This paper presents a methodology for automatically retrieve functional hierarchy for an OpenStreetMap derived road network from Floating Car Data, obtaining evenly distributed (e.g. for generalization purposes) or dynamic (e.g. to take into account differences in traffic volumes in different moments of the day) classifications. Road network elements are classified in function of vehicle speed values: the class distribution generated with the proposed methodology follows a linear distribution that can be better exploited for generalization purposes. Furthermore, the methodology allows to clearly distinguish different distributions in different moments of the day and days of the week, supporting traffic management activities

A SPATIAL DATABASE MODEL FOR MOBILITY MANAGEMENT

Abstract. In urban and metropolitan context, Traffic Operations Centres (TOCs) use technologies as Geographic Information Systems (GIS) and Intelligent Transport Systems (ITS) to tackling urban mobility issue. Usually in TOCs, various isolated systems are maintained in parallel (stored in different databases), and data comes from different sources: a challenge in transport management is to transfer disparate data into a unified data management system that preserves access to legacy data, allowing multi-thematic analysis. This need of integration between systems is important for a wise policy decision.This study aims to design a comprehensive and general spatial data model that could allow the integration and visualization of traffic components and measures. The activity is focused on the case study of 5T Agency in Turin, a TOC that manages traffic regulation, public transit fleets and information to users, in the metropolitan area of Turin and Piedmont Region.The idea is not to replace the existing implemented and efficient system, but to built-up on these systems a GIS that overpass the different software and DBMS platforms and that can demonstrate how a spatial and horizontal vision in tackling urban mobility issues may be useful for policy and strategies decisions. The modelling activity take reference from a review of transport standards and results in database general schema, which can be reused by other TOCs in their activities, helping the integration and coordination between different TOCs. The final output of the research is an ArcGIS geodatabase, which enable the customised representation of private traffic elements and measures.</p

Investigation of Vegetation Dynamics using Long-Term NormalizedDifference Vegetation Index Time-Series

Abstract: Problem statement: The Normalized Difference Vegetation Index (NDVI) is the most extensively used satellite-derived index of vegetation health and density. Since climate is one of the most important factors affecting vegetation condition, satellite-derived vegetation indexes have been often used to evaluate climatic and environmental changes at regional and global scale. The proposed study attempted to investigate the temporal vegetation dynamics in the whole Africa using historical NDVI time-series. Approach: For this aim, 15 day maximum value NDVI composites at 8 km spatial resolution produced from the NASA Global Inventory Mapping and Monitoring System (GIMMS) had been used. They were derived from data collected daily by NOAA AVHRR satellites. The AVHRR NDVI GIMMS dataset was freely available and gives global coverage over an extensive time period. First of all, the selected NDVI base data had been geometrically pre-processed and organized into a historical database implemented in order to grant their spatial integration. Starting from this archive, monthly and yearly NDVI historical time-series, extended from 1982-2006, had been then developed and analysed on a pixel basis. Several routines hade been developed in IDL (Interactive Data Language programming tool) with the purpose of applying suitable statistical analysis techniques to the historical information in the database in order to identify the long-term trend components of generated NDVI time-series and extract vegetation dynamics. Specific tests had been then considered in order to define the validity of results. Results: The existence of clear regional trends of NDVI, both decreasing and increasing had been showed, which helped to highlight areas subject, respectively to reduction or increase in vegetation greenness. Conclusion: As the relationship between the NDVI and vegetation productivity was well established, these estimated long-term trend components may be also, with much more caution, related to historical and ongoing land degradation or improvement processe

Floating car data (fcd) for mobility applications

Floating car data (FCD) is becoming more and more relevant for mobility domain applications, overcoming issues derived by the use of physical sensors (e.g. inductive loops, video observation, infrared and laser vehicle detection etc.), such as limited geographical distribution, measure inhomogeneities, limited or null coverage of minor roads. An increasing number of vehicles are equipped with devices capable of acquiring GPS positions and other data, transmitted in almost real-time to traffic control centres. Based on FCD data, several traffic analysis in support to mobility services can be performed: vehicle density, speed, origin-destination matrices, different patterns in function of vehicle type. If currently the representativeness of FCD can be considered an issue, current growing trend in FCD penetration should naturally overcome this issue. FCD are also higher sensitive to traffic events (e.g. traffic jams) than model-based approaches

Aerial LiDAR Technology in Support to Avalanches Prevention and Risk Mitigation: AN Operative Application at "colle della Maddalena" (italy)

Abstract. Snow avalanches are the result of unstable snow masses that detach from steep slopes as consequence of changes in snowpack structure. Nowadays, remote sensing technologies can improve the knowledge of avalanches phenomenon. This work focuses on the use of high point density aerial LiDAR (Light Detection And Ranging) technology as support to avalanche events prevention and risk mitigation, by presenting an operative application at Colle della Maddalena (Italy), along the road SS n. 21, nearby the French state border. The area is often involved in intense avalanche events that adversely impact on traffic and freight transport. For this reason, regional administrations will activate the Avalanche Artificial Detachment Intervention Plan (PIDAV, 2012) in order to prevent and manage the avalanche risk in the study area, also adopting artificial detachment systems. Main aim of the present work was to generate high resolution information related to geomorphological characterization (i.e. digital elevation models, slope and aspect) of avalanche sites derived from LiDAR data processing, that will help involved authorities in the management of the avalanche control plan. Digital elevation models at 0.5 m of spatial resolution were generated together with relative tridimensional models. Secondly, a preliminary investigation about capabilities and limits of LiDAR technology was done in the identification of avalanche sites only relying on geomorphological information directly derived by LiDAR data processing. Results showed that position of avalanche sites were correctly identified while no information could be obtained about the extension of the sliding area and identification of detachment areas