529 research outputs found
The role of stabilizing and communicating symptoms given overlapping communities in psychopathology networks
The role of stabilizing and communicating symptoms given overlapping communities in psychopathology networks
Medical and social costs after using financial incentives to improve medication adherence: results of a 1year randomised controlled trial
The effect of financial incentives on patients' motivation for treatment: results of "Money for Medication," a randomised controlled trial
Depot-medication compliance for patients with psychotic disorders: the importance of illness insight and treatment motivation
Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands
BACKGROUND: Cocaine, particularly in its base form ('crack'), has become one of the drugs of most concern in the Netherlands, being associated with a wide range of medical, psychiatric and social problems for the individual, and with significant public order consequences for society. Available treatment options for cocaine dependent users are limited, and a substantial part of the cocaine dependent population is not reached by the addiction treatment system. Psychosocial interventions for cocaine dependence generally show modest results, and there are no registered pharmacological treatments to date, despite the wide range of medications tested for this type of dependence. The present study (Cocaine Addiction Treatments to improve Control and reduce Harm; CATCH) investigates the possibilities and problems associated with new pharmacological treatments for crack dependent patients. METHODS/DESIGN: The CATCH-study consists of three separate randomised controlled, open-label, parallel-group feasibility trials, conducted at three separate addiction treatment institutes in the Netherlands. Patients are either new referrals or patients already in treatment. A total of 216 eligible outpatients are randomised using pre-randomisation double-consent design and receive either 12 weeks treatment with oral topiramate (n = 36; Brijder Addiction Treatment, The Hague), oral modafinil (n = 36; Arkin, Amsterdam), or oral dexamphetamine sustained-release (n = 36; Bouman GGZ, Rotterdam) as an add-on to cognitive behavioural therapy (CBT), or receive a 12-week CBT only (controls: n = 3 × 36). Primary outcome in these feasibility trials is retention in the underlying psychosocial treatment (CBT). Secondary outcomes are acceptance and compliance with the study medication, safety, changes in cocaine (and other drug) use, physical and mental health, social functioning, and patient satisfaction. DISCUSSION: To date, the CATCH-study is the first study in the Netherlands that explores new treatment options for crack-cocaine dependence focusing on both abstinence and harm minimisation. It is expected that the study will contribute to the development of new treatments for one of the most problematic substance use disorders. TRIAL REGISTRATION: The Netherlands National Trial Register NTR2576 The European Union Drug Regulating Authorities Clinical Trials EudraCT2009-010584-1
Weinig invloed stalen roosters op klauwgezondheid
Op stalen roosters is de klauwgezondheid van melkkoeien niet of nauwelijks slechter dan op betonnen roosters. De aard van de aandoeningen is verschoven van infectieuze aandoeningen naar beschadigingen van mechanische aard. De koeien vertonen zowel op stalen als op betonnen roosters hetzelfde vreetgedrag
Mestscheiding met stro
Mestscheiding staat regelmatig in de belangstelling. Er kunnen allerlei redenen zijn waarom het creëren van een dikke en een dunne fractie uit gewone mest interessant kan zijn, zoals mestafzet of een preciezere bemesting. Vaak zijn echter de kosten van het scheiden te hoog. Het PR heeft daarom gekeken naar de technische mogelijkheden van een eenvoudige scheidingstechniek met stro als filtermedium. Het lijkt mogelijk een groot deel van de fosfaat in de dikke fractie te concentreren, waarbij echter weleen deel van de stikstof verloren gaat
- …