Management organisation and ethics in the public sector

Over the past two decades in Australia and other developed nations, public sector management philosophies and how the public sector is organised have changed dramatically. At the same time, there have been many demands, and several attempts, to preserve and promote ethical behaviour within the public sector - though few go much beyond the publication of a Code. Both developments require an understanding of how public organisations operate in this new environment. Organisational and management theory are seen as providing important potential insights into the opportunities and pitfalls for building ethics into the practices, culture, and norms of public organisations. This book brings together the experience and research of a range of 'reflective practitioners' and 'engaged academics' in public sector management, organisational theory, management theory, public sector ethics and law. It addresses what management and organisation theory might suggest about the nature of public organisations and the institutionalisation of ethics

Engaged government: A study of government - community engagement for regional outcomes. Report 1: Project overview

The devolution of government business to regional government/community partnerships, coupled with the call for greater policy coherence, is challenging all levels of government and communities to collaborate in new ways to deliver regional outcomes. There is little empirical research to guide public managers in determining best value arrangements and strategic investments for building a region’s ‘collaborative advantage’. This project will examine the conditions (strategic, structural and procedural) under which multi-sectoral collaboration can deliver policy coherence and positive regional outcomes and identify the costs, benefits, trade-offs and capacities associated with effective multi-sectoral collaboration. Case studies for the project are being sourced in the central Queensland region. The project is being designed to explore some theoretical issues as well as a series of practical considerations about engagement processes. Key methodologies will be drawn from the political science, sociology and economics disciplines, and an action research framework will be adopted to maximise the value of project outcomes and engagement with industry partners. This report outlines the broad context in which the studies will be undertaken

Engaged government: A study of government - community engagement for regional outcomes. Report 2: Selection of case studies

The process of engagement between government and communities is changing as governments respond to different pressures, communities become more sophisticated in requiring services from government, and public sector managers try new mechanisms to deliver services to regional communities. The change processes are challenging as governments devolve some business to regional areas and community partnerships, try to provide coherence in policy outcomes across a range of government institutions, and explore different mechanisms to engage with communities. While government managers are already grappling with these issues, there has been little systematic research to either inform or analyse what is happening in practice

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy1. The study of large patient cohorts incorporating longitudinal plasma sampling and extended follow-up is required to determine the role of ctDNA as a phylogenetic biomarker of relapse in early-stage non-small-cell lung cancer (NSCLC). Here we developed ctDNA methods tracking a median of 200 mutations identified in resected NSCLC tissue across 1,069 plasma samples collected from 197 patients enrolled in the TRACERx study2. A lack of preoperative ctDNA detection distinguished biologically indolent lung adenocarcinoma with good clinical outcome. Postoperative plasma analyses were interpreted within the context of standard-of-care radiological surveillance and administration of cytotoxic adjuvant therapy. Landmark analyses of plasma samples collected within 120 days after surgery revealed ctDNA detection in 25% of patients, including 49% of all patients who experienced clinical relapse; 3 to 6 monthly ctDNA surveillance identified impending disease relapse in an additional 20% of landmark-negative patients. We developed a bioinformatic tool (ECLIPSE) for non-invasive tracking of subclonal architecture at low ctDNA levels. ECLIPSE identified patients with polyclonal metastatic dissemination, which was associated with a poor clinical outcome. By measuring subclone cancer cell fractions in preoperative plasma, we found that subclones seeding future metastases were significantly more expanded compared with non-metastatic subclones. Our findings will support (neo)adjuvant trial advances and provide insights into the process of metastatic dissemination using low-ctDNA-level liquid biopsy.</p