Binding Small Molecules to a cis-Dicarbonyl 99^{\text{99}}TcITc^{\text{I}}-PNP Complex via Metal–Ligand Cooperativity

Metal–ligand cooperativity is a powerful tool for the activation of various bonds but has rarely, if ever, been studied with the radioactive transition metal $^{\text{99}}$Tc. In this work, we explore this bond activation pathway with the dearomatized PNP complex cis-[99TcI(PyrPNPtBu*)(CO)2] (4), which was synthesized by deprotonation of trans-[99TcI(PyrPNPtBu)(CO)2Cl] with KOtBu. Analogous to its rhenium congener, the dearomatized compound reacts with CO2 to form the carboxy complex cis-[99TcI(PyrPNPtBu–COO)(CO)2] and with H2 to form the mono-hydride complex cis-[99TcI(PyrPNPtBu)(CO)2H] (7). Substrates with weakly acidic protons are deprotonated by the Brønsted basic pincer backbone of 4, yielding a variety of intriguing complexes. Reactions with terminal alkynes enable the isolation of acetylide complexes. The deprotonation of an imidazolium salt results in the in situ formation and coordination of a carbene ligand. Furthermore, a study with heterocyclic substrates allowed for the isolation of pyrrolide and pyrazolide complexes, which is uncommon for Tc. The spectroscopic analyses and their solid-state structures are reported

Forward--Backward Asymmetry in B -> X_s l^+ l^- at the NNLL Level

We report the results of a new calculation of soft-gluon corrections in B -> X_s l^+ l^- decays. In particular, we present the first calculation of bremsstrahlung and corresponding virtual terms to the lepton forward-backward asymmetry, which allows us to systematically include all contributions to this observable beyond the lowest non-trivial order. The new terms are important, for instance the position of the zero of the asymmetry receives corrections of O(10%). Using a different method, we also provide an independent check of recently published results on bremsstrahlung and infrared virtual corrections to the dilepton-invariant mass distribution.Comment: 20 pages, 5 figures. v2: typo in (4.26) corrected; discussion on mu-dependence modifie

NNLL QCD Corrections to the Decay B→Xsℓ+ℓ−B \to X_s \ell^+ \ell^-

We briefly discuss the status of the NNLL QCD calculations in the inclusive rare B decay $B \to X_s \ell^+ \ell^-$. Two important ingredients, the two-loop matrix elements of the four quark operator ${\cal O}_2$ and the bremsstrahlung contributions, were quite recently finalised. The new contributions significantly improve the sensitivity of the inclusive decay $B \to X_s l^+ l^-$ decay in testing extensions of the standard model in the sector of flavour dynamics; for instance the two-loop calculation cuts the low- scale uncertainty in half and the bremsstrahlung calculation leads to a 10% shift of the position of the zero of the forward- backward asymmetry.Comment: 7 pages, latex, 5 figures, references adde

Soft SUSY Breaking Grand Unification: Leptons vs Quarks on the Flavor Playground

We systematically analyze the correlations between the various leptonic and hadronic flavor violating processes arising in SUSY Grand Unified Theories. Using the GUT-symmetric relations between the soft SUSY breaking parameters, we assess the impact of hadronic and leptonic flavor observables on the SUSY sources of flavor violation.Comment: 39 pages, 10 figure

Flavor changing Z-decays from scalar interactions at a Giga-Z Linear Collider

The flavor changing decay Z -> d_I \bar{d}_J is investigated with special emphasis on the b \bar{s} final state. Various models for flavor violation are considered: two Higgs doublet models (2HDM's), supersymmetry (SUSY) with flavor violation in the up and down-type squark mass matrices and SUSY with flavor violation mediated by R-parity-violating interaction. We find that, within the SUSY scenarios for flavor violation, the branching ratio for the decay Z -> b \bar{s} can reach 10^{-6} for large \tan\beta values, while the typical size for this branching ratio in the 2HDM's considered is about two orders of magnitudes smaller at best. Thus, flavor changing SUSY signatures in radiative Z decays such as Z -> b \bar{s} may be accessible to future ``Z factories'' such as a Giga-Z version of the TESLA design.Comment: 27 pages, 15 figures, REVTeX4. A new section added and a few minor corrections were made in the tex

B decays and Supersymmetry

I discuss how supersymmetry affects various observables in B decays, and point out the interesting channels in the context of B factories.Comment: LaTex file of working group talk presented at WHEPP-7, HRI, Allahabad, Jan. 200

Calculation of two-loop virtual corrections to b --> s l+ l- in the standard model

We present in detail the calculation of the virtual O(alpha_s) corrections to the inclusive semi-leptonic rare decay b --> s l+ l-. We also include those O(alpha_s) bremsstrahlung contributions which cancel the infrared and mass singularities showing up in the virtual corrections. In order to avoid large resonant contributions, we restrict the invariant mass squared s of the lepton pair to the range 0.05 < s/mb^2 < 0.25. The analytic results are represented as expansions in the small parameters s/mb^2, z = mc^2/mb^2 and s/(4 mc^2). The new contributions drastically reduce the renormalization scale dependence of the decay spectrum. For the corresponding branching ratio (restricted to the above s-range) the renormalization scale uncertainty gets reduced from +/-13% to +/-6.5%.Comment: 41 pages including 9 postscript figures; in version 2 some typos and inconsistent notation correcte

Stau LSP and comparison with H^+(-) phenomenology

In supersymmetric models with explicit breaking of R-parity the lightest supersymmetric particle (LSP) may be the lightest stau, \stau_1. Such a scenario would provide a clear sign of R-parity violating SUSY, although its phenomenology may resemble that of a charged Higgs boson, $H^\pm$. We discuss various ways of distinguishing a LSP \stau_1 from $H^\pm$ at future colliders, and address the case of \stau_1 mimicking the signal for $H^\pm$. As an example we suggest that the recent L3 signal for $H^+H^-\to qq'qq'$ and $H^+H^-\to qq'\tau\nu_{\tau}$ could be more easily explained by a LSP \stau_1.Comment: 22 pages, 2 figures, Revtex, short discussion and references adde

b -> s gamma in the left-right supersymmetric model

The rare decay $b \to s \gamma$ is studied in the left-right supersymmetric model. We give explicit expressions for all the amplitudes associated with the supersymmetric contributions coming from gluinos, charginos and neutralinos in the model to one-loop level. The branching ratio is enhanced significantly compared to the standard model and minimal supersymmetric standard model values by contributions from the right-handed gaugino and squark sector. We give numerical results coming from the leading order contributions. If the only source of flavor violation comes from the CKM matrix, we constrain the scalar fermion-gaugino sector. If intergenerational mixings are allowed in the squark mass matrix, we constrain such supersymmetric sources of flavor violation. The decay $b \to s \gamma$ sets constraints on the parameters of the model and provides distinguishing signs from other supersymmetric scenarios.Comment: 12 figure

Functional features of gene expression profiles differentiating gastrointestinal stromal tumours according to KIT mutations and expression

<p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in <it>KIT </it>or <it>PDGFRA </it>of the type III receptor tyrosine kinase family. Although mutations in either receptor are thought to drive an early oncogenic event through similar pathways, two previous studies reported the mutation-specific gene expression profiles. However, their further conclusions were rather discordant. To clarify the molecular characteristics of differentially expressed genes according to GIST receptor mutations, we combined microarray-based analysis with detailed functional annotations.</p> <p>Methods</p> <p>Total RNA was isolated from 29 frozen gastric GISTs and processed for hybridization on GENECHIP^®HG-U133 Plus 2.0 microarrays (Affymetrix). <it>KIT </it>and <it>PDGFRA </it>were analyzed by sequencing, while related mRNA levels were analyzed by quantitative RT-PCR.</p> <p>Results</p> <p>Fifteen and eleven tumours possessed mutations in <it>KIT </it>and <it>PDGFRA</it>, respectively; no mutation was found in three tumours. Gene expression analysis identified no discriminative profiles associated with clinical or pathological parameters, even though expression of hundreds of genes differentiated tumour receptor mutation and expression status. Functional features of genes differentially expressed between the two groups of GISTs suggested alterations in angiogenesis and G-protein-related and calcium signalling.</p> <p>Conclusion</p> <p>Our study has identified novel molecular elements likely to be involved in receptor-dependent GIST development and allowed confirmation of previously published results. These elements may be potential therapeutic targets and novel markers of <it>KIT </it>mutation status.</p