Szilimarin ciklodextrin-komplexek vizsgálata

Elfogadva - Dr. Gunda TamásTanulmányi rendszerbe betöltv

Szilimarin - ciklodextrin komplexek vizsgálata

Munkám során ciklodextrin-szilimarin komplexeket állítottam elő. A képzett komplexeket MS és HPLC módszerekkel vizsgálatuk. In vitro toxicitási vizsgálatot Caco-2 sejtvonalon végeztünk.egységes, osztatlangyógyszerészmagyarnappalig

Szilimarin oldékonyságának növelése ciklodextrin-származékokkal

Siófok, 2012, XVII. Országos Gyógyszertechnológiai Konferencia és IX. Gyógyszer az Ezredfordulón KonferenciaElfogadom - Dr. Gunda TamásTanulmányi rendszerbe betöltv

Assessment of community efforts to advance network-based prediction of protein-protein interactions

peer reviewedComprehensive understanding of the human protein-protein interaction (PPI) network, aka the human interactome, can provide important insights into the molecular mechanisms of complex biological processes and diseases. Despite the remarkable experimental efforts undertaken to date to determine the structure of the human interactome, many PPIs remain unmapped. Computational approaches, especially network-based methods, can facilitate the identification of previously uncharacterized PPIs. Many such methods have been proposed. Yet, a systematic evaluation of existing network-based methods in predicting PPIs is still lacking. Here, we report community efforts initiated by the International Network Medicine Consortium to benchmark the ability of 26 representative network-based methods to predict PPIs across six different interactomes of four different organisms: A. thaliana, C. elegans, S. cerevisiae, and H. sapiens. Through extensive computational and experimental validations, we found that advanced similarity-based methods, which leverage the underlying network characteristics of PPIs, show superior performance over other general link prediction methods in the interactomes we considered