Curschmann's spirals in cyst fluid associated with a teratoma of the ovary - A case report

BACKGROUND: Curschmann's spirals, first described more than 100 years ago, are common in cytologic specimen from the respiratory tract and have also been observed in cervical smears, urine, and peritoneal and pleural effusions. No simple theory can explain the exact mode of spiral formation, which is presumed to be a complex physical and biochemical phenomenon

Stereologically estimated mean nuclear volume and histopathologic malignancy grading as predictors of disease extent in non-small cell lung carcinoma

The aim of this study was to investigate the value of the architectural grade, cytologic atypia, mitotic counts and stereologically estimated mean nuclear volume in predicting the stage of disease in non-small cell lung carcinomas. Hematoxylin-Eosin-stained sections from 53 non-small cell lung carcinomas were evaluated in terms of the morphologic and morphometric features mentioned above. Mean nuclear volume was estimated stereologically. Operable and inoperable tumor stages were compared concerning the parameters examined. There was no significant difference between operable and inoperable tumor stages in terms of the architectural grade in both squamous cell carcinomas and adenocarcinomas, although we found a positive correlation between architectural grades and increasing stages in SCC. Significant differences were found concerning atypia, mitosis grades, and the score combining both variables (C2) when comparing operable with inoperable tumor stages in squamous cell carcinomas but not in adenocarcinomas (Chi square, p = 0.013, p = 0.008 and p = 0.008 for squamous cell carcinomas respectively). The mean nuclear volumes of tumor cells in both squamous cell carcinomas and adenocarcinomas showed statistically significant differences between operable and inoperable stages (p = 0.05 and 0.02 respectively)

Role of apoptosis, bcl-2 and bax protein expression in premature rupture of fetal membranes

OBJECTIVE: To examine the degree of apoptosis in human fetal membranes associated with premature rupture Of membranes (PROM) as compared with normal pregnancies and to evaluate the expression of proapoptotic bax and antiapoptotic bcl-2 gene products

Repair of cartilage defects with periosteal grafts.

Alternative sources for repair of cartilage defects are limited and donor sites are associated with morbidity. It is known that cartilage development from periosteal grafts is possible. Various factors have been found positively to affect this process in experimental settings. However, all of these studies were limited to joint cartilage

Locally recurrent paratesticular rhabdomyosarcoma treated with surgery and radiotherapy

Paratesticular rhabdomyosarcoma is a highly malignant neoplasm and is exceedingly rare in adults, Thus, its biological behavior is unclear and there is no standard established treatment, The prognosis of recurrent paratesticular rhabdomyosarcoma is dismal in the elderly. Herein we describe a case of locally recurrent paratesticular rhabdomyosarcoma in a 68-year-old patient treated with surgery and radiotherapy

HHV-8 and EBV Positive Lymphoproliferative Disease: A Challenging Case.

Human herpes virus-8 (HHV-8) is linked to four lymphoproliferative diseases: primary effusion lymphoma, HHV-8 positive multicentric Castleman disease (MCD), HHV-8 positive diffuse large B cell lymphoma and HHV-8 positive germinotropic lymphoproliferative disorder (GLPD). The diagnosis of HHV-8 associated lymphoproliferative diseases is quite challenging because each entity is rare and has a wide morphological spectrum. Our aim is to emphasize the overlapping histopathological features of MCD and GLPD as well as to underline the importance of clinicopathological correlation in case these two entities cannot be distinguished by pathological examination

Association of macrophages, mast cells and eosinophil leukocytes with angiogenesis and tumor stage in non-small cell lung carcinomas (NSCLC).

The association between inflammatory cells, including tumor associated macrophage (TAM), mast cell (MC) and eosinophil Leucocyte (EL) densities and angiogenesis, as well as the relation of TAM, MC and EL densities and angiogenesis to tumor stage were investigated in specimens of 63 non-small cell lung carcinoma (NSCLC). Fifteen cases were in stage I, 12 were in stage II, 33 were in stage III and 3 were in stage IV. ELs and MCs were identified by hematoxilen-eosin and toluidine-blue histochemical stains, respectively. TAMs were shown by immunohistochemistry for CD68. Microvessets demonstrated by immunohistochemistry for CD31 were quantified by a stereotogical method and vascular surface density (VSD) and microvessel number (NVES) were calculated. There was not any statistically significant correlation between tumor's stage and VSD, TAM and EL counts. MC count and NVES were found to be higher, in early stages. VSD and NVES were not associated with EL, MC and TAM counts. The lack of consistent correlation of angiogenesis to the stage of disease in this study supports the view that tumor angiogenesis is not a significant prognostic factor in NSCLCs. The absence of correlation between MCs, ELs and TAM counts and angiogenesis and absence of any relation between ELs and TAMs and tumor stage are discordant with the results of some of the previous studies in NSCLCs and in other tumors. The differing results may be due to wide variations in methodologies which were used for demonstration of inflammatory cells and vessels and variations in the degree of activation and complexity of functions of these cells. (C) 2003 Elsevier Ireland Ltd. All rights reserved

Fibrosis in Hodgkin and non-Hodgkin lymphomas.

There is little quantitative information about the amount of fibrosis in lymphomas. The aim of the present study was to investigate the amount of fibrosis in lymphomas and to highlight the relationship between fibrosis and mast cells, the key players of fibrosis

Penile lesion with inguinal adenopathy after intravesical Bacillus Calmette-Guerin instillation therapy

Intravesical Bacillus Calmette-Guérin (BCG) is widely used as an adjuvant therapy in the treatment of non-muscle-invasive bladder cancer. BCG is generally well tolerated, though localized and systemic infectious complications may occur. Infection of the glans and inguinal adenopathy are rare local complications of intravesical BCG therapy. Traumatic urethral catheterization is one of the main causes. We report the case of a 75-year-old male who developed granulomatous balanitis and enlarged inguinal lymph nodes after five cycles of intravesical BCG treatment for transitional cell carcinoma of the bladder. Histology revealed giant cell granuloma. Oral antituberculous treatment was initiated with subsequent full recovery of penile lesions and adenopathy. Physicians who administer BCG must be familiar with the possible complications and their adequate management and should inform patients about the side-effects accordingly