Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method

Aim

SodiumPhosphate (NaP) versus polyethylene glycol-electrolyte lavage solution (PEG-ELS) tolerability: a prospective randomized study in patients with gynecological malignancy

Purpose: The aim of the study was to evaluate patient tolerability and compliance to two bowel cleansing agents (PEG-ELS and NaP) as well as to compare the cost effectiveness. Methods: Three hundred and forty-three consecutive patients were randomized to receive either the standard 4 1 of polyethylene glycol and electrolyte lavage solution (PEG-ELS) or 90 ml of sodium phosphate (NaP). All patients were advised to be on a clear liquid diet one day before starting the bowel cleansing regimen and to take ornidazole orally (3 x 2 tablets) 24 hours before surgery. Patient tolerabilty and compliance to the regimens were assessed based on complaints of nausea, vomiting and the need of antiemetics. In addition completion of the regimens was evaluated in both groups. Results: The need for antiemetics because of nausea and vomiting was statistically higher in the PEG-ELS group than the NaP group (p = 0.000). Regimen completion rate was statistically higher in the NaP group than in the PEG-ELS group (p = 0.000). NaP is more cost effective than PEG-ELS. Conclusion: NaP was rated superior to PEG-ELS in terms of patient tolerability, compliance, completion of the regimen and cost effectiveness and should be the first-choice treatment

Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea

Aim: The aim of the study was to examine whether there was a relationship between primary dysmenorrhea and serum levels of malondialdehyde (MDA), nitric oxide (NO) and adrenomedullin (AM) in young women

The Changes of Plasma Malondialdehyde, Nitric Oxide, and Adrenomedullin Levels in Patients with Preeclampsia

Objective. The aim of the study was to investigate the role of malondialdehyde, nitric oxide and adrenomedullin in the etiopathogenesis of preeclampsia. Material and Methods. Forty-two pregnant women with preeclampsia and 30 healthy pregnant women were involved. The plasma concentrations of malondialdehyde, nitric oxide, and adrenomedullin were compared between the study group and the control group. Results. In women with preeclampsia the plasma concentrations of malondialdehyde was higher while nitric oxide and adrenomedullin concentrations were lower compared to control subjects. Conclusion. We concluded that the plasma levels of ADM and NO are decreased while MDA levels are increased in subjects with preeclampsia and that might contribute to the pathophysiology of preeclampsia through the lack of a paracrine vasodilatory effect on uteroplacental blood flow

Paraoxonase-1 Polymorphisms (L55M/Q192R) and Activities (PONase/AREase) in Patients with Idiopathic Recurrent Early Pregnancy Loss: A Preliminary Study

Aim: To evaluate the associations between idiopathic recurrent early pregnancy loss (REPL) and paraoxonase-1 (PON1) polymorphisms and the activities of its encoded enzymes. Materials and Methods: Ninety-eight women were enrolled in this study, including 21 currently pregnant multiparous women without a history of miscarriage; 18 multiparous women who were not pregnant during the study; 30 women with a history of idiopathic REPL who were pregnant; and 29 who were not. Paraoxonase (PONase) and arylesterase (AREase) activities, two activities of the PON1 enzyme, were measured through commercially available kits (Relassay, Gaziantep, Turkey). PON1 genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Data were analyzed using SPSS for Windows version 19.0 (SPSS). Results: There was no association between idiopathic REPL and PON1 polymorphisms or PONase activity. The AREase activity of the PON1 enzyme trended higher in the healthy pregnant group than in the healthy nonpregnant group (p = 0.067), and was higher in the pregnant group with a history of idiopathic REPL than in the nonpregnant group with a history of idiopathic REPL (p = 0.041). Conclusions: Despite there being no detected association between PON1 activities or genotype and idiopathic REPL, we showed that AREase activity increased during early gestation. New studies, including longitudinal changes in serum AREase activity throughout normal pregnancy, should be carried out to further evaluate the association between PON encoded enzymatic activities and early gestational pathophysiology

The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism

Flutamide is an effective drug in treatment of hirsutism. Hepatotoxicity occasionally may occur with therapeutic doses (750-1500 mg/day), 3 months after initiation of treatment. Monitoring of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels is recommended to obviate serious hepatotoxicity

Effect of Ramadan fasting on maternal oxidative stress during the second trimester: A preliminary study

Aim: To evaluate whether fasting during Ramadan has any significant effects on maternal oxidative stress or fetal health in healthy, pregnant women with an uncomplicated, second-trimester, singleton pregnancy

Association between urotensin II gene polymorphism and pre-eclampsia

Objective: To investigate the association of a specific polymorphism (S89N) in exon 3 of the urotensin II (UTS2) gene in pre-eclampsia

MYELOPEROXIDASE GENE PROMOTOR POLYMORPHYSM IN MOTHERS WHO HAVE A CHILD WITH NEURAL TUBE DEFECT

Objective: The inflammatory pathway genes myeloperoxidase (MPO) is involved with regulation of inflammation through reactions with hydrogen peroxide (H2O2). The MPO enzyme is expressed abundantly in neutrophils, in which its antimicrobial function converts (H2O2) to the bacterocidal and DNA-damaging hypochlorous acid. Our aim was in this study to investigate whether there is a relationship between MPO gene (rs 2333227) polymorphysm (-463G/A) and neural tube defects