Supplementary Material for: A Retrospective analysis of 83 patients with testicular mass who underwent testis-sparing surgery: The Eurasian Uro-oncology Association Multicenter Study*

ABSTRACT Introduction: Herein,we analyzed the histopathological, oncologic and functional outcomes of TSS in patient with distinct risk for testicular cancer. Methods: This is a multicenter retrospective study on consecutive patients who underwent TSS. Patients were categorized in high- or low-risk Testicular Germ Cell Tumor(TGCT) according to the presence/absence of features compatible with Testicular Dysgenesis Syndrome(TDS). Histology was categorized per size and risk groups. Results: TSS was performed in 83 patients(86 tumors) of them, 27 in the high-risk group. Fifty-nine patients had a non-tumoral contralateral testis present. Sixty masses and 26 mases were benign and TGCTs respectively. No statistical differences were observed in mean age(30.9±10.32 years), pathological tumor size(14.67 ± 6.7 mm) between risk groups or between benign and malignant tumors(p=0.608). When categorized per risk groups 22(73.3%) and 4(7.1%) of the TSS specimens were malignant in the high- and low-risk patient groups respectively.Univariate analysis showed that the only independent variable significantly related to malignant outcome was previous history of TGCT. During a mean follow-up of 25.5±22.7 months no patient developed systemic disease. Local recurrence was detected in 5 patients and received RO. Postoperative testosterone levels remained normal in 88% of those patients with normal preoperative level. No ED was reported in patients with benign lesions. Conclusion: TSS is a safe and feasible approach with adequate cancer control and preservation of sexual function is possible in 2/3 of patients harboring malignancy. Incidence of TGCT varies extremely between patients at high and low risk for TGCT requiring a careful consideration and counseling