Histology of metastatic colorectal cancer in a lymph node.

BackgroundA primary colorectal cancer (CRC) tumor can contain heterogeneous cancer cells. As clones of cells with different properties metastasize to lymph nodes (LNs), they could show different morphologies. Cancer histologies in LNs of CRC remains to be described.MethodsOur study enrolled 318 consecutive patients with CRC who underwent primary tumor resection with lymph node dissection between January 2011 and June 2016. 119 (37.4%) patients who had metastatic LNs (mLNs) were finally included in this study. Cancer histologies in LNs were classified and compared with pathologically diagnosed differentiation in the primary lesion. The association between histologies in lymph node metastasis (LNM) and prognosis in patients with CRC was investigated.ResultsThe histologies of the cancer cells in the mLNs were classified into four types: tubular, cribriform, poorly differentiated, and mucinous. Same degree of pathologically diagnosed differentiation in the primary tumor produced various histological types in LNM. In Kaplan-Meier analysis, prognosis was worse in CRC patients with moderately differentiated adenocarcinoma who had at least some mLN also showing cribriform carcinoma than for those whose mLNs all showed tubular carcinoma.ConclusionsHistology in LNM from CRC might indicate the heterogeneity and malignant phenotype of the disease

Histology of metastatic colorectal cancer in a lymph node

Background A primary colorectal cancer (CRC) tumor can contain heterogeneous cancer cells. As clones of cells with different properties metastasize to lymph nodes (LNs), they could show different morphologies. Cancer histologies in LNs of CRC remains to be described. Methods Our study enrolled 318 consecutive patients with CRC who underwent primary tumor resection with lymph node dissection between January 2011 and June 2016. 119 (37.4%) patients who had metastatic LNs (mLNs) were finally included in this study. Cancer histologies in LNs were classified and compared with pathologically diagnosed differentiation in the primary lesion. The association between histologies in lymph node metastasis (LNM) and prognosis in patients with CRC was investigated. Results The histologies of the cancer cells in the mLNs were classified into four types: tubular, cribriform, poorly differentiated, and mucinous. Same degree of pathologically diagnosed differentiation in the primary tumor produced various histological types in LNM. In Kaplan–Meier analysis, prognosis was worse in CRC patients with moderately differentiated adenocarcinoma who had at least some mLN also showing cribriform carcinoma than for those whose mLNs all showed tubular carcinoma. Conclusions Histology in LNM from CRC might indicate the heterogeneity and malignant phenotype of the disease

Homogeneous cancer histology presenting in a single metastatic lymph node.

(A,B) Tubular adenocarcinoma. (C,D) Cribriform adenocarcinoma. (E,F) Poorly differentiated adenocarcinoma. (G,H) Mucinous adenocarcinoma. Original magnification: A, C, E, G: 40×; B, D, F, H: 100×. Staining: Hematoxylin and eosin.</p

Cancer histology in metastatic lymph nodes.

(A,B) Tubular. (C,D) Cribriform. (E,F) Poorly differentiated. (G,H) Mucinous. Original magnification: A, C, E, G: 100×; B, D, F, H: 400×. Staining: Hematoxylin and eosin.</p

Histologic cancer types in the lymph nodes of 119 node-positive patients with colorectal cancer.

Histologic cancer types in the lymph nodes of 119 node-positive patients with colorectal cancer.</p

Kaplan–Meier plots of cancer-specific survival (CSS) in node-positive disease.

CSS when all metastatic lymph nodes (mLNs) showed tubular carcinoma (“tub”), all mLNs showed cribriform carcinoma (“cri”), and some mLNs showed either tubular or cribriform carcinoma (“tub+cri”). All analyzed patients had a primary tumor classified as moderately differentiated adenocarcinoma.</p

A Σp\Sigma p scattering Experiment at J-PARC and the Analysis Status

International audienceJ-PARC E40 aims to measure the differential cross sections of the Σ^±p elastic scatterings and the Σ^−p → Λn conversion. A clear peak of Σ^− was observed in a missing mass spectrum of the π^−p → K^+X reaction and recoil protons from the πp elastic scattering were successfully observed in the data taken in the summer 2018. The rest of data taking is coming in the spring 2019