Natural Resources of Okyeman- an Overview

Biodiversity in all its forms sustains tremendous socio-economic and cultural interests of millions of people all over the world. Increasing human population has resulted in proportional increase in the demand for natural resources for the sustenance of human development needs. Unsustainable pattern of utilization of biodiversity in most parts of the world has necessitated the need for new thinking in the management of biodiversity. One key approach to managing these resources is through community-based approaches as opposed the classic approach to managing natural resources. The Akyem Abuakwa Traditional Area (Okyeman) in the Eastern Region of Ghana offers some lessons on community approaches in managing natural resources. Okyeman is one of the ecologically endowed areas in Ghana. The Traditional Area boasts of rich biodiversity including endemic, rare and globally threatened fauna and flora as well as diverse landscape of aesthetic value. Atewa Range Forest Reserve, one of the ecologically unique sites in Ghana is a prominent feature in the traditional area which is a home to many of the fauna and flora resources of the traditional area. However, these have in recent times come under intense pressure from illegal and unsustainable exploitation. This situation has compromised the ecological and biological integrity of Okyeman. Recognizing the need to reverse the situation, the traditional council has in recent times taken the initiative to use the existing  traditional structures to enhance natural resource governance in the area. This chapter gives an overview of the current status of natural resource of the traditional area, highlighting on their importance to local people and the need for sustainable exploitation of these resources

The Perceptions of Local Communities towards the Conservation of Birds in an Important Bird Area in Ghana

The important bird areas (IBA) concept provides a practical index of the diversity and condition of an ecosystem on a site-by-site basis using birds as indicators. It is believed that protecting and managing such sites will result in the conservation of some of the most sensitive, fragile and ecologically rich habitats in the world. However, acceptance of the IBA concept and, thus, site conservation action, by local communities is dependent on their perception of the importance of birds with regard to some aspects of their livelihood. The study was undertaken to examine the importance local communities around an IBA, the Afadjato and Agumatsa Conservation Area in Ghana, attach to conservation of birds, and their relevance as an indicator of environmental quality. Results obtained from a questionnaire survey, combined with group interviews, suggest that the importance local communities attached to bird conservation in the area was, to a large extent, dependent on the village or locality where people lived.West African Journal of Applied Ecology Vol. 13 2008: pp. 111-11

Food preferences of the common tern, sterna hirundo (Linnaeus, 1758) at the Densu floodplains, Accra

Seabirds are important in the dynamics of marine ecosystems because they recycle important biomass of lower trophic level organisms. Their faeces and carcasses provide important food sources for terrestrial and benthic scavengers. As a result of the abundance of food resources along the coast of Ghana, common terns (Sterna hirundo) are found in large numbers in productive brackish or saltwater wetlands, and are notable for indicating location of rich fish stocks at sea and in lagoons. The study aimed to determine the variety of food available, and any food preferences exhibited by S. hirundo at the Densu floodplains near Accra. While earlier studies of food habits of seabirds worldwide used examination of regurgitates and telescopic observations, the study quantitatively analyzed guts of common tern for their food content using standardized methods. The utilization by common terns of the Panbros lagoon fish resource during roosting in the night was quantified. Results showed that food available to the birds included marine and fresh or brackish water fish, crustaceans and worms. During caging, only one bird fed on 15 individuals of Hemichromis fasciatus. Prey items such as exoskeleton of crab zoea larvae, capitellid worms, fish otolith, pieces of fish bones and vertebrae, detrital materials and sand grains were found in the guts. The presence of capitellid worms in the guts, a known indicator of excess nutrient enrichment, showed that S. hirundo utilized the Panbros lagoon fish resource in feeding, and the roosting ground was under much stress. The study stressed the importance of complementing conservation efforts for common terns with attempts to manage the fish resources in the Densu floodplains

Large mammal Fauna of the Afadjato and Agumatsa range in Ghana: An important bird area

The Mount Afadjato and Agumatsa Range Conservation Area (AACA) is one of the globally important bird area in Ghana, currently being managed through community-based conservation actions by local people with the support of the Ghana Wildlife Society. As in many other Ghanaian communities the mammal fauna of the site continue to decline as a result of many factors, basically anthropogenic in origin. The aim of the study was to assess the status of large mammals in the area in terms of their diversity, relative abundance, density, and species of local, national and international conservation concern, and the factors likely to affect these variables. The diversity, relative abundance and densities of mammal species at the site are one of the lowest in Ghanaian forests. There is every indication that the major factors causing the decline in mammal population in the area are habitat degradation and hunting pressure. As in many other communities in the West African sub-region, all mammals are negatively impacted upon by human activities. Consequently, given that whatever activities being proposed by the locally initiated community-based conservation programme will greatly depend on availability of wildlife, especially for ecotourism, there is a need for a more pragmatic approach to conserve the remaining wildlife without further delay

Tool kits for the Sustainable Management of Ghana’s Riverine Biodiversity: an Overveiw

The Darwin Initiative funded project Tool kits for the Sustainable Management of Ghana’s Riverine Biodiversity was a collaboration between the Centre for African Wetlands at the University of Ghana, various units of the University of Ghana and the Ghana Wildlife Society. The project also involved collaborators from Burkina Faso, Nigeria, Cote d’Ivoire, Togo and Benin. The project aimed to address the impediments that remain for Ghana (and its neighbouring countries) in applying the Ecosystem Approach (EA) to riverine wetland management and the delivery of the Convention on Biodiversity (CBD). Priority needs were identified as taxonomic capacity building, a contemporary assessment of the status of aquatic biodiversity in Ghana, the development of practical management tools for rivers and increased engagement of stakeholders in decision-making together with an enhanced environmental awareness throughout Ghanaian society. These were addressed in this project by regional and local staff training, reporting on the current status of aquatic communities, the production of educational and taxonomic resources for a range of users, the development of a set of nested indicators of ecosystem health adapted for use at various levels, and the production of a policy document outlining the means of applying the EA in the management of Ghana’s rivers

Clinical features, acute complications, and outcome of Salmonella meningitis in children under one year of age in Taiwan

<p>Abstract</p> <p>Background</p> <p><it>Salmonella </it>meningitis remains a threat to children below two years of age in both developing and developed countries. However, information on such infections has not been well characterized. We analyzed data related to twelve years of experience in order to clarify the comprehensive features of <it>Salmonella </it>meningitis in our patients, including admission characteristics, acute complications, and long-term outcome.</p> <p>Methods</p> <p>The records of patients with spontaneous <it>Salmonella </it>meningitis from 1982 to 1994 were retrospectively reviewed. The long-term outcome was prospectively determined for survivors at school age by the developmental milestones reported by their parents and detailed neurological evaluation along with intelligence, hearing, visual, speech and language assessments.</p> <p>Results</p> <p>Of the twenty-four patients, seizures were noted in fifteen (63%) before admission and thirteen (54%) during hospitalization. Acute complications mainly included hydrocephalus (50%), subdural collection (42%), cerebral infarction (33%), ventriculitis (25%), empyema (13%), intracranial abscess (8%), and cranial nerve palsy (8%). Three patients (13%) died during the acute phase of <it>Salmonella </it>meningitis. The twenty-one survivors, on whom we followed up at school age, have sequelae consisting of language disorder (52%), motor disability (48%), intelligence quotient < 80 (43%), epilepsy (33%), sensorineural hearing loss (17%), visual deficits (10%), abducens nerve palsy (5%), microcephaly (5%), and hydrocephalus (5%). Overall, good outcome was noted in six (28.6%) of twenty-one survivors, mild sequelae in three (14.2%), moderate in six (28.6%), and severe in six (28.6%).</p> <p>Conclusion</p> <p><it>Salmonella </it>meningitis in neonates and infants had a wide spectrum of morbidity and acute complications, leading to a complicated hospital course and subsequently a high prevalence of permanent adverse outcome. Thus, early recognition of acute complications of <it>Salmonella </it>meningitis and a follow-up plan for early developmental assessment of survivors are vital.</p

KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species

KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal intracerebral hemorrhage. Comprehensive analysis of the KRIT1 gene in CCM patients has suggested that KRIT1 functions need to be severely impaired for pathogenesis. However, the molecular and cellular functions of KRIT1 as well as CCM pathogenesis mechanisms are still research challenges. We found that KRIT1 plays an important role in molecular mechanisms involved in the maintenance of the intracellular Reactive Oxygen Species (ROS) homeostasis to prevent oxidative cellular damage. In particular, we demonstrate that KRIT1 loss/down-regulation is associated with a significant increase in intracellular ROS levels. Conversely, ROS levels in KRIT1−/− cells are significantly and dose-dependently reduced after restoration of KRIT1 expression. Moreover, we show that the modulation of intracellular ROS levels by KRIT1 loss/restoration is strictly correlated with the modulation of the expression of the antioxidant protein SOD2 as well as of the transcriptional factor FoxO1, a master regulator of cell responses to oxidative stress and a modulator of SOD2 levels. Furthermore, we show that the KRIT1-dependent maintenance of low ROS levels facilitates the downregulation of cyclin D1 expression required for cell transition from proliferative growth to quiescence. Finally, we demonstrate that the enhanced ROS levels in KRIT1−/− cells are associated with an increased cell susceptibility to oxidative DNA damage and a marked induction of the DNA damage sensor and repair gene Gadd45α, as well as with a decline of mitochondrial energy metabolism. Taken together, our results point to a new model where KRIT1 limits the accumulation of intracellular oxidants and prevents oxidative stress-mediated cellular dysfunction and DNA damage by enhancing the cell capacity to scavenge intracellular ROS through an antioxidant pathway involving FoxO1 and SOD2, thus providing novel and useful insights into the understanding of KRIT1 molecular and cellular functions

Endomyocardial Fibrosis: Still a Mystery after 60 Years

The pathologist Jack N. P. Davies identified endomyocardial fibrosis in Uganda in 1947. Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America. In Kampala, the disease accounts for 20% of heart disease patients referred for echocardiography. We conducted a systematic review of research on the epidemiology and etiology of endomyocardial fibrosis. We relied primarily on articles in the MEDLINE database with either “endomyocardial fibrosis” or “endomyocardial sclerosis” in the title. The volume of publications on endomyocardial fibrosis has declined since the 1980s. Despite several hypotheses regarding cause, no account of the etiology of this disease has yet fully explained its unique geographical distribution

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030