Rapid assembly of highly-functionalised difluorinated cyclooctenones via ring-closing metathesis

Building block methodology from trifluoroethanol and ringclosing metathesis using a Fürstner modification of Grubbs’ conditions allows the rapid synthesis of novel difluorinated cyclooctenones

Isoxazole to oxazole: a mild and unexpected transformation

3-Aryltetrahydrobenzisoxazoles prepared en route to the coleophomone natural products and analogues, were found to undergo a remarkable base-mediated rearrangement to 2-aryltetrahydrobenzoxazoles. The scope of this unprecedented, facile transformation was probed: a range of analogues was produced, a mechanism proposed, and an application demonstrated by synthesis of a known herbicidal compound

Palladium-catalysed couplings of difluoroenol carbamate derivatives

1-(N,N-Diethylcarbamoyloxy)-2,2-difluoro-1-iodo- and 1-(N,N-Diethylcarbamoyloxy)-2,2-difluoro-1-(tributylstannyl)-ethenes undergo Stille and Suzuki-Miyaura couplings with some generality and some significant limitations

Isoxazole to oxazole: a mild and unexpected transformation

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.3-Aryltetrahydrobenzisoxazoles prepared en route to the coleophomone natural products and analogues, were found to undergo a remarkable base-mediated rearrangement to 2-aryltetrahydrobenzoxazoles. The scope of this unprecedented, facile transformation was probed: a range of analogues was produced, a mechanism proposed, and an application demonstrated by synthesis of a known herbicidal compound