Examining skilled reading processes

Skilled reading often occurs with little effort. However, when basic reading processes are analyzed in detail, the illusion of simplicity is removed. The present research focuses on the proficiency with which a skilled reader can successfully access lexical (i.e., whole-word) and sublexical (i.e., sub-word) levels of orthographic and phonological knowledge. In particular, I will address questions pertaining to: (1) the nature of the connections between sub-processes of basic visual word recognition, (2) the degree to which context affects whole-word versus sub-word processing, and (3) whether there are neuroanatomical correlates that correspond to the sub-processes of basic visual word recognition. The findings presented in this set of experiments support:(1) facilitation-dominant connections from orthography to phonology, (2) context related whole-word and sub-word processing, and (3) lexical and sublexical neuroanatomical correlates of basic reading processes. The findings are discussed with respect to the issue of whether there is a single processing route from orthography to phonology or if there are two processing routes from orthography to phonology

2014 Fed Challenge Script: Current State of the Economy

Good afternoon everyone and thank you for having us here today. Though the recession began in 2007 and officially ended in 2009, recovery has been painfully slow. GDP growth has been insufficient to close the output gap, there continues to be slack in the labor market and inflation has stabilized below the Federal Reserve percent target. We are not meeting our dual mandate of full employment and stable prices even 6 years after the end of the recession. Despite some signs of strengthening in the economy during the past year, we do not believe that economy is on a self-sustaining path of recovery. Furthermore, the monetary policy actions taken by the Fed thus far to pull us out of the Great Recession have been insufficient. We propose a substantial strengthening of the our forward guidance; specifically, a commitment not to raise the federal funds rate until nominal GDP has returned to a path that we consider consistent with the dual mandate. [excerpt

The Dynamics of Abell 2125

We present 371 galaxy velocities in the field of the very rich cluster Abell 2125 (z~0.25). These were determined using optical spectroscopy collected over several years from both the WIYN 3.5m telescope and NOAO Mayall 4m telescope. Prior studies at a variety of wavelengths (radio, optical, and X-ray) have indicated that A2125 is a likely cluster-cluster merger, a scenario which we are able to test using our large velocity database. We identified 224 cluster galaxies, which were subjected to a broad range of statistical tests using both positional and velocity information to evaluate the cluster dynamics and substructure. The tests confirmed the presence of substructures within the Abell 2125 system at high significance, demonstrating that A2125 is a complex dynamical system. Comparison of the test results with existing simulations strengthens the merger hypothesis, and provides clues about the merger geometry and stage. The merger model for the system can reconcile A2125's low X-ray temperature and luminosity with its apparently high richness, and might also explain A2125's high fraction of active galaxies identified in prior radio and optical studies.Comment: 34 pages, including tables and 3 color figures; to appear in Ap

c-Src drives intestinal regeneration and transformation

The non‐receptor tyrosine kinase c‐Src, hereafter referred to as Src, is overexpressed or activated in multiple human malignancies. There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and potential activating mutations in up to 20% of the human tumours, although this has never been addressed due to multiple redundant family members. Here, we have used the adult <i>Drosophila</i> and mouse intestinal epithelium as paradigms to define a role for Src during tissue homeostasis, damage‐induced regeneration and hyperplasia. Through genetic gain and loss of function experiments, we demonstrate that Src is necessary and sufficient to drive intestinal stem cell (ISC) proliferation during tissue self‐renewal, regeneration and tumourigenesis. Surprisingly, Src plays a non‐redundant role in the mouse intestine, which cannot be substituted by the other family kinases Fyn and Yes. Mechanistically, we show that Src drives ISC proliferation through upregulation of EGFR and activation of Ras/MAPK and Stat3 signalling. Therefore, we demonstrate a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation <i>in vivo.</i&gt

Biomimetic direction of arrival estimation for resolving front-back confusions in hearing aids

Sound sources at the same angle in front or behind a two-microphone array (e.g., bilateral hearing aids) produce the same time delay and two estimates for the direction of arrival: A front-back confusion. The auditory system can resolve this issue using head movements. To resolve front-back confusion for hearing-aid algorithms, head movement was measured using an inertial sensor. Successive time-delay estimates between the microphones are shifted clockwise and counterclockwise by the head movement between estimates and aggregated in two histograms. The histogram with the largest peak after multiple estimates predicted the correct hemifield for the source, eliminating the front-back confusions

The incidence of postoperative venous thrombosis among patients with ulcerative colitis

Background: Patients with Ulcerative Colitis (UC) have inherent prothrombotic tendencies. It is unknown whether this necessitates the use of additional perioperative anti-thrombotic prophylaxis when such patients require major surgery. Methods: The postoperative courses of 79 patients with UC undergoing 180 major abdominal and pelvic operations were examined for clinical and radiological evidence of venous thrombosis. Eighteen patients with Familial Adenomatous Polyposis (FAP) having surgery (35 operations) of similar magnitude were also studied. Standard anti-thrombosis prophylaxis was utilised in all patients. Results: Nine patients with UC were clinically suspected of developing postoperative venous thrombosis, but only three (3.8%) had their diagnosis confirmed radiologically (all had a pulmonary embolus). Therefore, the overall postoperative thrombosis rate, on an intention to treat basis, was 1.7% (3/180). No patient with FAP developed significant venous thrombosis. Conclusion: Standard perioperative antithrombotic modalities are sufficient to maintain any potential increase in postoperative thrombotic risk at an acceptable level in patients with UC undergoing operative intervention

The Evolving Role of Faculty: Traditional Scholarship, Instructional Scholarship and Service Scholarship

Faculty workload decisions made by a departmental unit often create a conflict for faculty because promotion/tenure decisions usually focus primarily on individual scholarly achievements. This paper describes an approach to faculty evaluation that considers both departmental and individual needs by expanding the view of scholarship to include Research, Instruction, and Service

Biomimetic direction of arrival estimation for resolving front-back confusions in hearing aids

Sound sources at the same angle in front or behind a two-microphone array (e.g., bilateral hearing aids) produce the same time delay and two estimates for the direction of arrival: A front-back confusion. The auditory system can resolve this issue using head movements. To resolve front-back confusion for hearing-aid algorithms, head movement was measured using an inertial sensor. Successive time-delay estimates between the microphones are shifted clockwise and counterclockwise by the head movement between estimates and aggregated in two histograms. The histogram with the largest peak after multiple estimates predicted the correct hemifield for the source, eliminating the front-back confusions