Parallel-propagating Fluctuations at Proton-kinetic Scales in the Solar Wind are Dominated by Kinetic Instabilities

We use magnetic helicity to characterise solar wind fluctuations at proton-kinetic scales from Wind observations. For the first time, we separate the contributions to helicity from fluctuations propagating at angles quasi-parallel and oblique to the local mean magnetic field, $\mathbf{B}_0$. We find that the helicity of quasi-parallel fluctuations is consistent with Alfv\'en-ion cyclotron and fast magnetosonic-whistler modes driven by proton temperature anisotropy instabilities and the presence of a relative drift between $\alpha$-particles and protons. We also find that the helicity of oblique fluctuations has little dependence on proton temperature anisotropy and is consistent with fluctuations from the anisotropic turbulent cascade. Our results show that parallel-propagating fluctuations at proton-kinetic scales in the solar wind are dominated by proton temperature anisotropy instabilities and not the turbulent cascade. We also provide evidence that the behaviour of fluctuations at these scales is independent of the origin and macroscopic properties of the solar wind.Comment: Accepted for publication in ApJL. 6 Pages, 3 figures, 1 tabl

The Role of Proton-Cyclotron Resonance as a Dissipation Mechanism in Solar Wind Turbulence: A Statistical Study at Ion-Kinetic Scales

We use magnetic field and ion moment data from the MFI and SWE instruments onboard the Wind spacecraft to study the nature of solar wind turbulence at ion-kinetic scales. We analyze the spectral properties of magnetic field fluctuations between 0.1 and 5.5 Hz over 2012 using an automated routine, computing high-resolution 92 s power and magnetic helicity spectra. To ensure the spectral features are physical, we make the first in-flight measurement of the MFI `noise-floor' using tail-lobe crossings of the Earth's magnetosphere during early 2004. We utilize Taylor's hypothesis to Doppler-shift into the spacecraft frequency frame, finding that the spectral break observed at these frequencies is best associated with the proton-cyclotron resonance scale, $1/k_c$, compared to the proton inertial length $d_i$ and proton gyroscale $\rho_i$. This agreement is strongest when we consider periods where $\beta_{i,\perp}\sim1$, and is consistent with a spectral break at $d_i$ for $\beta_{i,\perp}\ll1$ and $\rho_i$ for $\beta_{i,\perp}\gg1$. We also find that the coherent magnetic helicity signature observed at these frequencies is bounded at low frequencies by $1/k_c$ and its absolute value reaches a maximum at $\rho_i$. These results hold in both slow and fast wind streams, but with a better correlation in the more Alfv\'enic fast wind where the helicity signature is strongest. We conclude that these findings are consistent with proton-cyclotron resonance as an important mechanism for dissipation of turbulent energy in the solar wind, occurring at least half the time in our selected interval. However, we do not rule out additional mechanisms.Comment: 16 pages, 11 figures. Accepted for publication in The Astrophysical Journal. Please contact authors to obtain WIND MFI 'noise-floor' for use in other studie

3D modelling of angiogenesis and vascular tumour growth

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute

Multiscale modelling of vascular tumour growth in 3D: the roles of domain size & boundary condition

We investigate a three-dimensional multiscale model of vascular tumour growth, which couples blood flow, angiogenesis, vascular remodelling, nutrient/growth factor transport, movement of, and interactions between, normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. In particular, we determine how the domain size, aspect ratio and initial vascular network influence the tumour's growth dynamics and its long-time composition. We establish whether it is possible to extrapolate simulation results obtained for small domains to larger ones, by constructing a large simulation domain from a number of identical subdomains, each subsystem initially comprising two parallel parent vessels, with associated cells and diffusible substances. We find that the subsystem is not representative of the full domain and conclude that, for this initial vessel geometry, interactions between adjacent subsystems contribute to the overall growth dynamics. We then show that extrapolation of results from a small subdomain to a larger domain can only be made if the subdomain is sufficiently large and is initialised with a sufficiently complex vascular network. Motivated by these results, we perform simulations to investigate the tumour's response to therapy and show that the probability of tumour elimination in a larger domain can be extrapolated from simulation results on a smaller domain. Finally, we demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour

Parametrizations of Inclusive Cross Sections for Pion Production in Proton-Proton Collisions

Accurate knowledge of cross sections for pion production in proton-proton collisions finds wide application in particle physics, astrophysics, cosmic ray physics and space radiation problems, especially in situations where an incident proton is transported through some medium, and one requires knowledge of the output particle spectrum given the input spectrum. In such cases accurate parametrizations of the cross sections are desired. In this paper we review much of the experimental data and compare to a wide variety of different cross section parametrizations. In so doing, we provide parametrizations of neutral and charged pion cross sections which provide a very accurate description of the experimental data. Lorentz invariant differential cross sections, spectral distributions and total cross section parametrizations are presented.Comment: 32 pages with 15 figures. Published in Physical Review D62, 094030. File includes 6 tex files. The main file is paper.tex which has include statements refering to the rest. figures are in graphs.di

Predictive significance of the six-minute walk distance for long-term survival in chronic hypercapnic respiratory failure

Background: The 6-min walk distance ( 6-MWD) is a global marker of functional capacity and prognosis in chronic obstructive pulmonary disease ( COPD), but less explored in other chronic respiratory diseases. Objective: To study the role of 6-MWD in chronic hypercapnic respiratory failure ( CHRF). Methods: In 424 stable patients with CHRF and non-invasive ventilation ( NIV) comprising COPD ( n = 197), restrictive diseases ( RD; n = 112) and obesity-hypoventilation- syndrome ( OHS; n = 115), the prognostic value of 6-MWD for long- term survival was assessed in relation to that of body mass index (BMI), lung function, respiratory muscle function and laboratory parameters. Results: 6-MWD was reduced in patients with COPD ( median 280 m; quartiles 204/350 m) and RD ( 290 m; 204/362 m) compared to OHS ( 360 m; 275/440 m; p <0.001 each). Overall mortality during 24.9 (13.1/40.5) months was 22.9%. In the 424 patients with CHRF, 6-MWD independently predicted mortality in addition to BMI, leukocytes and forced expiratory volume in 1 s ( p <0.05 each). In COPD, 6-MWD was strongly associated with mortality using the median {[} p <0.001, hazard ratio ( HR) = 3.75, 95% confidence interval (CI): 2.24-6.38] or quartiles as cutoff levels. In contrast, 6-MWD was only significantly associated with impaired survival in RD patients when it was reduced to 204 m or less (1st quartile; p = 0.003, HR = 3.31, 95% CI: 1.73-14.10), while in OHS 6-MWD had not any prognostic value. Conclusions: In patients with CHRF and NIV, 6-MWD was predictive for long- term survival particularly in COPD. In RD only severely reduced 6-MWD predicted mortality, while in OHS 6-MWD was relatively high and had no prognostic value. These results support a disease-specific use of 6-MWD in the routine assessment of patients with CHRF. Copyright (C) 2007 S. Karger AG, Basel

A hypothetico-deductive approach to assessing the social function of chemical signalling in a non-territorial solitary carnivore

The function of chemical signalling in non-territorial solitary carnivores is still relatively unclear. Studies on territorial solitary and social carnivores have highlighted odour capability and utility, however the social function of chemical signalling in wild carnivore populations operating dominance hierarchy social systems has received little attention. We monitored scent marking and investigatory behaviour of wild brown bears Ursus arctos, to test multiple hypotheses relating to the social function of chemical signalling. Camera traps were stationed facing bear ‘marking trees’ to document behaviour by different age sex classes in different seasons. We found evidence to support the hypothesis that adult males utilise chemical signalling to communicate dominance to other males throughout the non-denning period. Adult females did not appear to utilise marking trees to advertise oestrous state during the breeding season. The function of marking by subadult bears is somewhat unclear, but may be related to the behaviour of adult males. Subadults investigated trees more often than they scent marked during the breeding season, which could be a result of an increased risk from adult males. Females with young showed an increase in marking and investigation of trees outside of the breeding season. We propose the hypothesis that females engage their dependent young with marking trees from a young age, at a relatively ‘safe’ time of year. Memory, experience, and learning at a young age, may all contribute towards odour capabilities in adult bears

Prevalence of and factors associated with late diagnosis of HIV in Malawi, Zambia, and Zimbabwe: Results from population-based nationally representative surveys

Introduction Late diagnosis of HIV (LD) increases the risk of morbidity, mortality, and HIV transmission. We used nationally representative data from population-based HIV impact assessment (PHIA) surveys in Malawi, Zambia, and Zimbabwe (2015–2016) to characterize adults at risk of LD and to examine associations between LD and presumed HIV transmission to cohabiting sexual partners. Methods We estimated the prevalence of LD, defined as CD4 count <350 cells/μL, among adults newly diagnosed with HIV during the surveys and odds ratios for associated factors. We linked newly diagnosed adults (index cases) to their household sexual partners and calculated adjusted odds ratios for associations between LD of the index case, viral load of the index case, and duration of HIV exposure in the relationship, and the HIV status of the household sexual partner. Results Of 1,804 adults who were newly diagnosed with HIV in the surveys, 49% (882) were diagnosed late. LD was associated with male sex, older age, and almost five times the odds of having an HIV-positive household sexual partner (adjusted odds ratio [aOR], 4.65 [95% confidence interval: 2.56–8.45]). Longer duration of HIV exposure in a relationship and higher viral load of the index case were both independently associated with higher odds of having HIV-positive household sexual partners. Individuals with HIV exposure of more than 5 years had more than three times (aOR 3.42 [95% CI: 1.63–7.18]) higher odds of being HIV positive than those with less than 2 years HIV exposure. The odds of being HIV positive were increased in individuals who were in a relationship with an index case with a viral load of 400–3499 copies/mL (aOR 4.06 [95% CI 0.45–36.46]), 3,500–9,999 copies/mL (aOR 11.32 [95% CI: 4.08–31.39]), 10,000–49,999 copies/mL (aOR 17.07 [95% CI: 9.18–31.72]), and ≥50,000 copies/mL (aOR 28.41 [95% CI: 12.18–66.28]) compared to individuals who were in a relationship with an index case with a viral load of <400 copies/mL. Conclusions LD remains a challenge in Southern Africa and is strongly associated with presumed HIV transmission to household sexual partners. Our study underscores the need for earlier HIV diagnosis, particularly among men and older adults, and the importance of index testing