АСПЕКТЫ ПРИМЕНЕНИЯ ИНДОМЕТАЦИНА В МЕДИЦИНЕ И ФАРМАЦИИ

Indomethacin, a non-steroid anti-inflammatory drug (NSAID), has been used in different spheres of medicine since the 1960s. It is successfully administered as an anti-inflammatory and pain-relieving medication in rheumatoid and other diseases. According to recent research, indomethacin may become a promising drug enhancing endogenous remyelination in patients with multiple sclerosis. Also, indomethacin affects cell proliferation and invasion, thus it is used to manage pancreatic cancer in patients with hyperglycemia. In addition, indomethacin can inhibit protein synthesis in colorectal carcinoma and other types of cancer cells. The article reviews modern indomethacin medications and the different dosage forms on the Russian pharmaceutical market. Indomethacin poor water solubility is one of the reasons for decreasing its biopharmaceutical characteristics. According to the conducted research, a prospective way to improve indomethacin solubility and bioavailability is the Solid Dispersion (SD) method. SDs are bi- or multicomponent systems consisting of the drug and the carrier. They are a highly dispersed solid phase of the drug or molecular-dispersed solid solutions with a partial formation of a variable composition complex and a carrier. The article provides a brief overview on different aspects of obtaining, investigating, and applying indomethacin SDs with various polymers.Синтезированный в шестидесятых годах прошлого столетия типичный представитель класса нестероидных противовоспалительных средств индометацин нашел широкое применение в различных областях медицины. Сочетание противовоспалительного и обезболивающего действия обусловило успешное применение индометацина при ревматических заболеваниях. Новейшие исследования выявили, что препарат может стать перспективным средством и в терапии ряда иных патологий. В статье приведен краткий обзор ассортимента современных препаратов и различных лекарственных форм индометацина на отечественном фармацевтическом рынке. Одним из факторов, снижающих биофармацевтические характеристики препаратов индометацина, является его малая растворимость в воде. Согласно результатам анализа литературных данных, одной из перспективных технологий, способных успешно увеличить растворимость и биодоступность индометацина, является метод получения его твердых дисперсий. Твердые дисперсии ― это би- или многокомпонентные системы из лекарственного вещества и носителя, представляющие собой высокодиспергированную твердую фазу лекарственного вещества или молекулярно-дисперсные твердые или жидкие растворы с частичным образованием комплексов переменного состава с материалом носителя. Представлен краткий обзор работ, посвященных различным аспектам получения, исследования и применения твердых дисперсий индометацина с разными полимерами-носителями

Application of Indomethacin in Medicine and Pharmacy

Indomethacin, a non-steroid anti-inflammatory drug (NSAID), has been used in different spheres of medicine since the 1960s. It is successfully administered as an anti-inflammatory and pain-relieving medication in rheumatoid and other diseases. According to recent research, indomethacin may become a promising drug enhancing endogenous remyelination in patients with multiple sclerosis. Also, indomethacin affects cell proliferation and invasion, thus it is used to manage pancreatic cancer in patients with hyperglycemia. In addition, indomethacin can inhibit protein synthesis in colorectal carcinoma and other types of cancer cells. The article reviews modern indomethacin medications and the different dosage forms on the Russian pharmaceutical market. Indomethacin poor water solubility is one of the reasons for decreasing its biopharmaceutical characteristics. According to the conducted research, a prospective way to improve indomethacin solubility and bioavailability is the Solid Dispersion (SD) method. SDs are bi- or multicomponent systems consisting of the drug and the carrier. They are a highly dispersed solid phase of the drug or molecular-dispersed solid solutions with a partial formation of a variable composition complex and a carrier. The article provides a brief overview on different aspects of obtaining, investigating, and applying indomethacin SDs with various polymers. © 2018 Izdatel'stvo Meditsina. All rights reserved

Solubility of Diclofenac Acid Form from Solid Dispersions

The influence of solid dispersions (SD) on diclofenac solubility was determined by studying diclofenac (acid form) and its SD with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP). SD formation increased the solubility and dissolution rate of the non-steroidal anti-inflammatory drug (NSAID). Diclofenac solubility from the SD with PVP increased by 2.5 times; from the SD with PEG (solvent evaporation method), by 8 times compared with diclofenac drug substance. A combination of physicochemical methods showed that the improved release of diclofenac from the SD occurred because of reduced crystallinity, formation of drug solid solutions in the polymer matrix, and formation of a colloidal drug solution. © 2015, Springer Science+Business Media New York

Application of Indomethacin in Medicine and Pharmacy

Indomethacin, a non-steroid anti-inflammatory drug (NSAID), has been used in different spheres of medicine since the 1960s. It is successfully administered as an anti-inflammatory and pain-relieving medication in rheumatoid and other diseases. According to recent research, indomethacin may become a promising drug enhancing endogenous remyelination in patients with multiple sclerosis. Also, indomethacin affects cell proliferation and invasion, thus it is used to manage pancreatic cancer in patients with hyperglycemia. In addition, indomethacin can inhibit protein synthesis in colorectal carcinoma and other types of cancer cells. The article reviews modern indomethacin medications and the different dosage forms on the Russian pharmaceutical market. Indomethacin poor water solubility is one of the reasons for decreasing its biopharmaceutical characteristics. According to the conducted research, a prospective way to improve indomethacin solubility and bioavailability is the Solid Dispersion (SD) method. SDs are bi- or multicomponent systems consisting of the drug and the carrier. They are a highly dispersed solid phase of the drug or molecular-dispersed solid solutions with a partial formation of a variable composition complex and a carrier. The article provides a brief overview on different aspects of obtaining, investigating, and applying indomethacin SDs with various polymers. © 2018 Izdatel'stvo Meditsina. All rights reserved

Solubility of Diclofenac Acid Form from Solid Dispersions

The influence of solid dispersions (SD) on diclofenac solubility was determined by studying diclofenac (acid form) and its SD with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP). SD formation increased the solubility and dissolution rate of the non-steroidal anti-inflammatory drug (NSAID). Diclofenac solubility from the SD with PVP increased by 2.5 times; from the SD with PEG (solvent evaporation method), by 8 times compared with diclofenac drug substance. A combination of physicochemical methods showed that the improved release of diclofenac from the SD occurred because of reduced crystallinity, formation of drug solid solutions in the polymer matrix, and formation of a colloidal drug solution. © 2015, Springer Science+Business Media New York

Перспективы применения лекарственных форм нифедипина в медицине и фармации (обзор)

The article describes aspects of the use of nifedipine. Nifedipine is an active substance that has not lost its relevance in modern medicine and pharmacy. The prospects for the use of existing drugs nifedipine are presented. The possibility of creating new dosage forms containing solid dispersions of nifedipine is being considered.Приведены аспекты применения нифедипина. Представлены перспективы использования существующих препаратов нифедипина. Рассмотрена возможность создания новых лекарственных форм, содержащих твердые дисперсии нифедипина