Критерии экологической безопасности железнодорожных перевозок

[For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version)].ABSRACT The article describes the case when railway transport complex is presented as an element within structured concept of national economy’s transition to sustainable development. A question of formulating objective criteria of environmental safety of freight and passenger transportation is discussed. Environmental aspects of operation of railways are developed, and criteria-based approaches to safety of railway-related infrastructure, rolling stock and environment are suggested. Keywords: railways, transportation, carriage, sustainable development, ecological aspects, criteria of environmental safety.Текст аннотации на англ. языке и полный текст статьи на англ. языке находится в прилагаемом файле ПДФ (англ. версия следует после русской версии).В данном случае железнодорожный транспортный комплекс представлен как элемент в структуре концепции перехода экономики страны к устойчивому развитию. При этом поднят вопрос о формировании объективных критериев экологической безопасности грузовых и пассажирских перевозок. Сформированы экологические аспекты эксплуатации железнодорожного транспорта и предложены критериальные основы безопасности причастных к дорогам инфраструктуры и подвижного состава, сопутствующей перевозкам среды

The clinical spectrum of non-dementia cognitive impairment: Subjective mild-to-moderate disorders

The important task of nevrology is to improve the diagnosis of chronic progressive degenerative and vascular brain diseases – to detect them at the earliest stages. The paper presents current views on the non-dementia stages of brain diseases: moderate, mild, and subjective cognitive impairments. It sets forth data on their prevalence and clinical features and types, as well as international diagnostic criteria. There is evidence for the expediency of the earliest neuroprotective therapy to prevent dementia. A methodology for neuroprotective therapy is discussed; the available data on the long-term effect of intermittent treatment cycles with the vasotropic and neurometabolic drug tanakan are given

Оценка вредных химических факторов при обслуживании аккумуляторных батарей

For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version).ABSTRACT The article analyzes the specifics of the aspects of occupational risk to the health of workers in the battery compartment of a passenger car depot caused by chemical contamination of the industrial environment. The results of the research of the heavy metal content in workrooms are presented, the issues of monitoring and normalizing labor conditions in the presence of harmful chemical factors are considered. Keywords: railway, car depot, storage batteries, chemical factor, heavy metals, control and rationing, production environment. REFERENCES 1.Aksenov, V.A., Raenok, D.L., Zavialov, A. M.System of Labor Protection and Professional Risks.World of Transport and Transportation, Vol.11, 2013, Iss.2, pp.164-169. 2.Ovanesova, E. A. Ecological and hygienic aspects of operation of modern types of storage batteries in passenger rail vehicles [Ekologo-gigienicheskie aspekty ekspluatacii sovremennyh tipov akkumuljatornyh batarej na passazhirskom zheleznodorozhnom podvizhnom sostave].Transport Complex in the Regions: Experience and Prospects for Traffic Organization: Materials of the International Scientific and Practical Conference.Ed.by A. A. Platonov.Voronezh, Runa publ., 2015, Iss.1, pp.59-62. 3.Yudaeva, O.S., Ovanesova, E. A. Some ecological and hygienic aspects of maintenance of accumulator batteries of the passenger rolling stock of railway transport [Nekotorye ekologo-gigienicheskie aspekty obsluzhivanija akkumuljatornyh batarej passazhirskogo podvizhnogo sostava zheleznodorozhnogo transporta].Nauka i tehnika transporta, 2015, Iss.4, pp.8-10. 4.Methodological recommendations on ensuring environmental safety of passenger cars of locomotive traction produced by JSC TVZ [Metodicheskie rekomendacii po obespecheniju ekologicheskoj bezopasnosti passazhirskih vagonov lokomotivnoj tjagi proizvodstva OAO «TVZ»].Moscow, VNIIZhG Rospotrebnadzor, 2012. 5.Ivanova, E.A., Belkov, V. M. Operation and utilization of nickel-cadmium batteries [Ekspluatacija i utilizacija nikel’-kadmievyh akkumuljatorov].Vestnik VNIIZhT, 2011, Iss.2, pp.32-34. 6.Methodology for conducting an inventory of emissions of pollutants into the atmosphere for motor transport enterprises (by calculation method).Approved by Ministry of Transport of the Russian Federation on 28.10.1998 [Metodika provedenija inventarizacii vybrosov zagrjaznjajushhih veshhestv v atmosferu dlja avtotransportnyh predprijatij (raschetnym metodom). Utv. Mintransom RF 28.10.1998]. 7.Grishin, S. V. Technology of processing cadmium, nickel-containing waste and discharge characteristics of nickel-cadmium batteries made from recycled materials.Ph.D.(Eng.) thesis [Tehnologija pererabotki kadmij-, nikel’soderzhashhih othodov i razrjadnye harakteristiki nikel’-kadmievyh akkumuljatorov, izgotovlennyh iz vtorichnogo syr’ja. Dis… kand. tehn. nauk].Saratov, 2007, 128 p. 8.Korovin, N. V. Electrochemical energy [Elektrohimicheskaja energetika].Moscow, Energoatomizdat publ., 1991, 264 p. 9.Khryukin, N. S. Ventilation and heating of battery rooms [Ventiljacija i otoplenie akkumuljatornyh pomeshhenij].Moscow, Energia publ., 1979, 120 p. 10.Gichev, Yu.P. Pollution of the environment and environmental conditioning of human pathology: Analytical review / GPNTB SO RAN [Zagrjaznenie okruzhajushhej sredy i ekologicheskaja obuslovlennost’ patologii cheloveka: Analit. obzor / GPNTB SO RAN].Novosibirsk, 2003, 138 p.Текст аннотации на англ. языке и полный текст статьи на англ. языке находится в прилагаемом файле ПДФ (англ. версия следует после русской версии).В статье анализируется специфика аспектов профессионального риска здоровью работников аккумуляторного отделения пассажирского вагонного депо, обусловленных химическим загрязнением производственной среды. Представлены результаты исследования содержания тяжелых металлов в рабочих помещениях, рассмотрены вопросы контроля и нормирования условий труда при наличии вредных химических факторов

Combination of bendamustine and rituximab in the management of relapsed and refractory chronic lymphocytic leukemia: the results of retrospective study

Efficacy and safety results of rituximab and bendamustine combination (Scheme BR) in patients with relapsed and refractory chronic lymphocytic leukemia (CLL) are presented. From 01.2012 to 04.2013, the treatment was initiated in 43 patients (21 with relapses are sensitive to the last line of therapy; 22 – with refractory CLL). Median age at start of therapy was 63.5 years (range from 43 to 81 years). In 40 patients response was evaluated according to NCI-WG criteria (1996). Complete remission (CR) is documented in 5 (12.5 %) cases, partial (PR) or nodular partial remission (nPR) in 17 (42.5 %) cases. MRD-negative CR was achieved in 1 (20.0 %) of 5 patients with CR. With 23.5 months of median follow-up for surviving patients 2-year progression-free survival (PFS) was 47.2 ± 8.5 % (median – 18.5 months), overall survival (OS) – 66.9 ± 7.9 % (median not achieved). Hematological toxicity Grade 3–4 occurred in 15 (34.9 %) cases, same degree infectious complicationsin 5 (11.6 %) cases. Patients received 3 or more therapy lines before this treatment (37.5 ± 16.1 % against 74.7 ± 8.3 %; p = 0.016), with «bulky disease» more than 10 cm (0.0 % vs. 75.4 ± 7.5 %; p &lt; 0.001) and received rituximab in combination with chemotherapy in the previous lines, compared to the «naive» cases (44.1 ± 10.5 % against 92.9 ± 6.9 %; p = 0.009) have significantly worsened 2-year OS.</p

Combination of bendamustine and rituximab in the management of relapsed and refractory chronic lymphocytic leukemia: the results of retrospective study

Efficacy and safety results of rituximab and bendamustine combination (Scheme BR) in patients with relapsed and refractory chronic lymphocytic leukemia (CLL) are presented. From 01.2012 to 04.2013, the treatment was initiated in 43 patients (21 with relapses are sensitive to the last line of therapy; 22 – with refractory CLL). Median age at start of therapy was 63.5 years (range from 43 to 81 years). In 40 patients response was evaluated according to NCI-WG criteria (1996). Complete remission (CR) is documented in 5 (12.5 %) cases, partial (PR) or nodular partial remission (nPR) in 17 (42.5 %) cases. MRD-negative CR was achieved in 1 (20.0 %) of 5 patients with CR. With 23.5 months of median follow-up for surviving patients 2-year progression-free survival (PFS) was 47.2 ± 8.5 % (median – 18.5 months), overall survival (OS) – 66.9 ± 7.9 % (median not achieved). Hematological toxicity Grade 3–4 occurred in 15 (34.9 %) cases, same degree infectious complicationsin 5 (11.6 %) cases. Patients received 3 or more therapy lines before this treatment (37.5 ± 16.1 % against 74.7 ± 8.3 %; p = 0.016), with «bulky disease» more than 10 cm (0.0 % vs. 75.4 ± 7.5 %; p &lt; 0.001) and received rituximab in combination with chemotherapy in the previous lines, compared to the «naive» cases (44.1 ± 10.5 % against 92.9 ± 6.9 %; p = 0.009) have significantly worsened 2-year OS