Connaissances des Anomalies du Tube Neural, Attitudes et Pratiques de Prévention chez les Femmes vues en Consultation prénatale, Région de Niamey-Niger, 2017: Knowledge, Attitudes and Prevention Practices of Neural Tube Anomalies in Women attending Prenatal Consultation in the Niamey-Niger Region 2017

Introduction: Les anomalies congénitales sont des anomalies fonctionnelles, structurelles ou métaboliques se produisant en intra-utérin et identifiables avant ou après la naissance. Au Niger, le domaine des anomalies congénitales n'a pas été suffisamment exploré. Notre objectif était de décrire les connaissances des anomalies du tube neural (ATN), les attitudes et les pratiques de prévention chez les femmes vues en consultation prénatale (CPN). Méthodes: Nous avons mené une enquête transversale de Février â Mars 2017 chez les femmes enceintes vues en CPN1 dans les maternités de Niamey. L'échantillon, calculé avec Open Epi était de 421. Les femmes enceintes ont été interviewées sur leurs connaissances des ATN, leurs attitudes et pratiques de prévention devant ces anomalies. Les données ont été collectées avec un questionnaire à travers les 5 districts sanitaires de la region de Niamey. Le nombre de femmes à enquêter par district a été alloué en tenant compte de l'importance relative des femmes en age de procréer (FAP) selon le district. Dans chaque district, il a été choisi par commodité, l'hôpital de district (HD), 2 maternités urbaines et 2 maternités rurales. Le nombre de femme par maternité a été déterminé selon le même procédé que dans les districts. A la maternité, les participantes ont été choisi de manière aléatoire. Des analyses univariées, bivariées et multivariées ont été réalisées. Des ratios de prévalence (RP), OR de prévalence (POR) à 95% ont été calculés. Les variables avec p<0,25 en analyse bivariée, ont été intégrées dans le modèle logistique multiple. Résultats: L'âge médian des enquêtées était de 25 ans. Il y avait 60,81% de scolarisées et 24,33% de primigestes. Environ 30,65% connaissaient les ATN ; 15,92% avaient de bonnes attitudes ; 41,81% avaient utilisées l'acide folique (AF). La tranche d'êge de 25-49ans a été un facteur indépendant de la connaissance des ATN (p=0,0008) ; pour les attitudes : il s'agit de l'âge (25-49ans) (p=0,03), la prise d'AF (p=0,0002) ; pour la pratique : le niveau d'instruction (p=0,01), l'information par les agents de santé (p< 0,0001), la connaissance d'autres sources d'AF (p=0,04). Conclusion: Il y avait une insuffisance de connaissances, d'attitudes et de pratiques de prévention devant les ATN chez les femmes enceintes. L'éducation continue, une politique d'enrichissement en AF de certains aliments s'impose. Background: Congenital anomalies are functional, structural or metabolic abnormalities occurring in the uterus and identifiable before or after birth. In Niger, the field of congenital anomalies has not been sufficiently explored. Our objective was to describe the knowledge of neural tube defects (NTDs), attitudes and prevention practices in women seen in antenatal care (ANC). Methods: We conducted a cross-sectional survey from February to March 2017 among pregnant women seen in CPN1 in maternity hospitals in Niamey. The sample, calculated with Open Epi, was 421. Pregnant women were interviewed on their knowledge of NTDs, their attitudes and prevention practices in the face of these anomalies. The data were collected with a questionnaire across the 5 health districts of the Niamey region. The number of women to be surveyed by district was allocated taking into account the relative importance of women of reproductive age (FAP) by district. In each district, it was chosen by convenience, the district hospital (HD), 2 urban maternities and 2 rural maternities. The number of women per maternity unit was determined using the same procedure as in the districts. In the maternity ward, the participants were chosen at random. Univariate, bivariate and multivariate analyzes were performed. 95% prevalence (PR), OR prevalence (POR) ratios were calculated. Variables with p <0.25 in bivariate analysis were included in the multiple logistic model. Results: The median age of the respondents was 25 years. There were 60.81% of school children and 24.33% of primigravidae. About 30.65% were familiar with ATNs; 15.92% had good attitudes; 41.81% had used folic acid (FA). The age group of 25-49 years was an independent factor of knowledge of NTDs (p = 0.0008); for attitudes: it is about age (25-49 years) (p = 0.03), AF intake (p = 0.0002); for practice: level of education (p = 0.01), information by health workers (p <0.0001), knowledge of other sources of FA (p = 0.04). Conclusion: There was a lack of knowledge, attitudes and prevention practices towards NTDs among pregnant women. Education continues, a policy of fortifying certain foods with AF is required

Etiology and risk factors for meningitis during an outbreak in Batié Health District, Burkina Faso, January-March 2016

Introduction: On 16 March 2016, Batié Health District notified the Burkina Faso Ministry of Health Surveillance unit of 12 suspected cases of meningitis. During the same period, Batié´s neighboring districts in Côte d'Ivoire and Ghana were experiencing a meningitis epidemic. We investigated to establish the etiology and risk factors for the disease and to recommend prevention and control measures. Methods: We conducted unmatched case control study. A case was any person living in Batié with fever (temp. ≥ 38.5°C) and any of the following: neck stiffness, neurological disorder, bulging fontanelle, convulsion during January to April 2016 with cerebrospinal fluid (CSF) positive to PCR. Controls were non sick household members, neighbors or friends to the cases. We analyzed the investigation and laboratory records. We included all confirmed cases and two neighborhood controls per case. We used a standard questionnaire to collect data. We analyzed data by Epi info 7 and calculated odds ratio (ORs),adjusted odds ratios (AOR) and 95% confidence interval. We proceeded to univariate, bivariate, multivariate and logistic regression analysis. Results: We interviewed 93 participants including 31 meningitis cases and 62 controls. The median age of cases was 8 years old [2 months-55 years] and 6.5 years old [5 months-51 years] for controls. Streptococcus pneumoniae 16(51.61%), Neisseria meningitidis W 14(45.16%) and Haemophilus influenzae b 1(3.23%) were the identified germs. The independent risk factors identified were travel to meningitis affected areas (Adjusted odd ratio(AOR)=12[2.3-60],p=0.0029); >5 persons sharing bedroom (AOR=5.7[1.5-22],p=0.012) and rhinopharyngitis (AOR=26[1.8-380],p=0.017). Conclusion: Streptococcus pneumoniae and Neisseria meningitidis W caused the outbreak in Batié. The risk factors were overcrowding, travel to affected areas, and rhinopharyngitis. We recommended reactive vaccination against Neisseria meningitidis W, limited travel to affected areas and ventilation of rooms

Evaluation of the Nutritional and Hematological Status of Sickle Cell Children Monitored in the Pediatric Department of the University Hospital Center of Yalgado Ouedraogo

Objective: To assess the nutritional and hematological status of sickle cell children followed in the department of pediatrics of the Yalgado Ouédraogo University Hospital Centre (CHU-YO).Methodology: This was a cross-sectional study conducted from September 1, 2017, to February 28, 2018. All children with major sickle cell syndrome followed in the department of pediatrics at the CHU-YO and following their follow-up appointments were included in the study.Results: We included 230 children aged 11 months to 16 years with an average age of 8.5 years. The sex M/F ratio was 1.09. The SC heterozygotes were the most represented with 56.52%. The average hemoglobin level was 9.39 g/dl. The prevalences of wasting, stunting and underweight were respectively 23.04%, 15.65%, and 13.89%. In univariate analysis, the factors associated with emaciation was hyperleukocytosis (p=0.002).The factors associated with stunting were leukocytosis (p=0.01), severe anemia (p=0.01), SS phenotype (p=0.002), age range of 5-10 years (p=0.007), Secondary (P=0.007) and higher level (p=0.001) of father’s education, secondary (p=0.027) and higher level (p=0.034)of mothers’education , farmer(p=0.003) trader (p=0.042), and informal occupation of father (p = 0.002),and breastfeeding duration after 24 months (p=0.006). For underweight associated factors in univariate analysis were SS phenotype (p=0.003) and severe anemia (p=0.01).Conclusion: The prevalence of different types of malnutrition deficiency of sickle cell children followed at CHU-YO was high. It is important to strengthen the nutritional monitoring of children with sickle cell disease for better management of the disease

Usage thérapeutique du manguier (Mangifera indica L., Anacardiaceae) au Burkina Faso

Les extraits d’organes de manguier (Mangifera indica L., Anacardiacaea) présentent un potentiel d’utilisation dans des applications pharmaceutiques. Le but de cette étude est de contribuer à une meilleure connaissance des vertus thérapeutiques du manguier au Burkina Faso. Des enquêtes ethnobotaniques ont été réalisées à l’aide de questionnaire auprès des phytothérapeutes de trois régions du Burkina Faso (Centre-Ouest, Hauts-Bassins et Cascades). Les résultats ont été obtenus auprès de 45 phytothérapeutes enquêtés. Ces phytothérapeutes sont représentés par 79% d’hommes et 21% de femmes. La tranche d’âge comprise entre 31 et 40 ans est la plus représentée, soit 32,41% et 59,25% des phytothérapeutes enquêté sont non scolarisés. Les résultats obtenus ont permis de répertorier des maladies couramment traitées avec les organes du manguier. De plus, les feuilles du manguier des variétés ordinaires (Mangot vert et sabre) surtout sont les plus utilisées dans la préparation médicamenteuse. La décoction est le mode de préparation le plus sollicité et l’administration des remèdes se fait par voie orale (100%). Une étude pharmacologique devrait permettre l’incorporation des extraits des organes du manguier dans des compléments alimentaires pour traiter certaines maladies.Mango (Mangifera indica L., Anacardiacaea) organ extracts have potential use in pharmaceutical applications. The aim of this study is to contribute to a better knowledge of mango health benefits in Burkina Faso. Ethnobotanical surveys were carried out using a questionnaire among herbalists in three regions of Burkina Faso (Centre-Ouest, Hauts-Bassins and Cascades). The results were obtained from 45 herbalists surveyed. These herbalists are represented by 79% men and 21% women. The age group between 31 and 40 years is the most represented, i.e. 32.41%, and 59.25% of the herbalists surveyed are illiterate. The results obtained made it possible to list the diseases commonly treated with mango organs. Moreover, mango leaves of the ordinary varieties (green mango and saber) are the most used in the preparation of medicines. Decoction is the most popular method of preparation and the remedies are administered by oral route (100%). A pharmacological study should make it possible to incorporate extracts of mango organs into food supplements to treat diseases

Distribution of ABO and RHD blood group antigens in blood donors in Burkina Faso.

Geographical distribution of ABO and RHD antigens is important for blood transfusion services and population genetics studies. There are few data on this topic in Burkina Faso, a multi-ethnic country. Our study aims at reporting phenotypic and allelic frequencies of ABO and RHD blood groups among voluntary blood donors from various ethnical regions of Burkina Faso. We conducted a cross-sectional study including 81,486 blood donors. ABO allelic frequencies were determined using the Bernstein method. Differences in phenotypic distribution of blood groups were assessed using the chi-square test; a p value B+>A+>AB+>O->B->A->AB- in our population. Phenotypic frequencies of blood groups A, B, O and AB were respectively 22.54%, 28.56%, 43.30% and 5.60%. RHD+was 92.24%. The allelic frequencies of A, B, O and D were respectively 0.1524; 0.1887; 0.6590 and 0.7214. We noticed statistical differences (p < 0.05) between these administrative regions which corresponded roughly to some natural ethnic areas. Indeed, the phenotype O was more frequent in the Central-west, Central and East regions corresponding to "Mossi," "Gourounsi," "Gourmantché" areas while the phenotype A and AB were more reported in "Boucle du mouhoun" and "Hauts-Bassins" regions where we have "Bwaba" and "Bobo." The phenotype O negative was less frequent in "Bwaba." Our study provides interesting information to blood services that will allow them to better refine their donor recruitment strategies

Profil de sensibilité des souches de pneumocoques aux antibiotiques avant l’introduction du vaccin anti pneumococcique conjugué à treize valences (PCV-13) au Burkina Faso

Introduction: Streptococcus pneumoniae constitue un pathogène important des méningites bactériennes aiguës au Burkina Faso. Cela a justifié l’introduction du vaccin pneumococcique conjugué en Octobre 2013 dans le programme élargi de vaccination chez les enfants de moins d’un an. L’objectif de ce travail consiste à établir le profil de sensibilité aux antibiotiques des souches de S. pneumoniae isolées du liquide cérébro-spinal. Méthodologie: Du 1er Janvier 2010 au 30 Décembre 2012, 37 souches de pneumocoques ont été collectées du réseau national de surveillance de la méningite du pays. Ces souches, repiquées sur de la gélose au sang frais, ont été confirmées par le test de sensibilité à l’optochine. Le test de Quellung a déterminé les sérotypes de pneumocoques et l’antibiogramme a été réalisé selon la méthode de diffusion et interprété selon le standard « European Committee of antibiotics susceptibility testing. Résultats: Sur 37 isolats sérotypés, 77% appartenaient aux sérotypes vaccinaux. L’antibiogramme a révélé que 92% des souches sensibles à l’oxacilline, 97% à l’érythromycine et 73% à la clindamycine. Le cotrimoxazole a été actif dans 14% et la tétracycline seulement 5% des souches. Conclusion: La majorité des souches de pneumocoques isolée des méningites au Burkina Faso appartiennent aux sérotypes vaccinaux. Mots clés: Sensibilité; Antibiotiques; Pneumocoques; PCV-13 English Title: Profile of antibiotics susceptibility testing of pneumococcal strains before the introduction of the thirteen-valent conjugate pneumococcal vaccine (PCV-13) in Burkina Faso English Abstract&nbsp; Introduction: Streptococcus pneumoniae is an important pathogen of acute bacterial meningitis in Burkina Faso. This justify the introduction of the thirteen-valent pneumococcal vaccine in October 2013 in the expanded program of immunization in children under one year old. The aim of this work is to establish the antibiotics susceptibility testing profile of strains of S. pneumoniae isolated from cerebrospinal fluid. Methods: From January 1st, 2010 to December 30th, 2012, 37 strains of pneumococci were collected from the country's national meningitis surveillance network. These strains, subcultured on fresh blood agar, were confirmed by the optochin susceptibility testing. The Quellung test made it possible by determining the pneumococcal serotypes and the antibiogram carried out according to the diffusion method and interpreted according to the standard "European Committee of antibiotics susceptibility testing”. Results: Of the thirty-seven typed isolates, 77% belonged to the vaccine serotypes. Susceptibility to antibiotics reports 92% of strains susceptible to oxacillin, 97% to erythromycin and 73% to clindamycin. Cotrimoxazole was active in 14% and tetracycline only 5% of the strains. Conclusion: The majority of pneumococcal strains isolated from meningitis in Burkina Faso belong to vaccine serotypes. Keywords: Antibiotics; susceptibility testing; Pneumococci; PCV-1