Teorie e sperimentalismo progettuale per la ricerca in tecnologia dell'architettura / Theories and experimental design for research in architectural technology

Il volume, che raccoglie riflessioni intorno al tema della città, intesa come campo di sperimentazione, traccia un panorama aggiornato della ricerca dottorale e post-dottorale in Tecnologia dell’Architettura, da cui traspare la volontà di offrire spunti teorici di ampio respiro e, contemporaneamente, testimoniare una vasta gamma di applicazioni specialistiche. Nell’approccio ambientale, che accoglie i suggerimenti dei territori valorizzandone la "cultura materiale", appare il tratto comune sul quale sono impostate molte delle tematiche di ricerca qui esposte. The book, that gathers reflections on the theme of the city, intended as field of experimentation, gives an updated panorama of the doctoral (PhD) and postdoctoral research in Architectural Technology, and offers ample theoretical insights as well as a large collection of specialized applications. The environmental approach, that welcomes suggestions from the surrounding areas, highlighting the "material culture", shows the common traits that are present in many of the research themes here exposed

L’ECONOMIA DELLE IDEE

Conferenza di Fabio Renzi, Direttore di Symbola, sulle dinamiche economiche e sociali della cultura italiana e del made in Ital

Vitamin C Deficiency in Patients With Acute Myeloid Leukemia

Vitamin C has been shown to play a significant role in suppressing progression of leukemia through epigenetic mechanisms. We aimed to study the role of vitamin C in acute myeloid leukemia (AML) biology and clinical course. To this purpose, the plasma levels of vitamin C at diagnosis in 62 patients with AML (including 5 cases with acute promyelocytic leukemia, APL),7 with myelodysplastic syndrome (MDS), and in 15 healthy donors (HDs) were studied. As controls, vitamins A and E levels were analysed. Expression of the main vitamin C transporters and of the TET2 enzyme were investigated by a specific RQ-PCR while cytoplasmic vitamin C concentration and its uptake were studied in mononuclear cells (MNCs), lymphocytes and blast cells purified from AML samples, and MNCs isolated from HDs. There were no significant differences in vitamin A and E serum levels between patients and HDs. Conversely, vitamin C concentration was significantly lower in AML as compared to HDs (p<0.0001), inversely correlated with peripheral blast-counts (p=0.029), significantly increased at the time of complete remission (CR) (p=0.04) and further decreased in resistant disease (p=0.002). Expression of the main vitamin C transporters SLC23A2, SLC2A1 and SLC2A3 was also significantly reduced in AML compared to HDs. In this line, cytoplasmic vitamin C levels were also significantly lower in AML-MNCs versus HDs, and in sorted blasts compared to normal lymphocytes in individual patients. No association was found between vitamin C plasma levels and the mutation profile of AML patients, as well as when considering cytogenetics or 2017 ELN risk stratification groups. Finally, vitamin C levels did not play a predictive role for overall or relapse-free survival. In conclusion, our study shows that vitamin C levels are significantly decreased in patients with AML at the time of initial diagnosis, further decrease during disease progression and return to normal upon achievement of CR. Correspondingly, low intracellular levels may mirror increased vitamin C metabolic consumption in proliferating AML cells

Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol

IDH1/2 mutations are common in acute myeloid leukemia (AML) and represent a therapeutic target. The GIMEMA AML1516 observational protocol was designed to study the prevalence of IDH1/2 mutations and associations with clinico-biological parameters in a cohort of Italian AML patients. We analyzed a cohort of 284 AML consecutive patients at diagnosis, 139 females and 145 males, of a median age of 65 years (range: 19–86). Of these, 38 (14%) harbored IDH1 and 51 (18%) IDH2 mutations. IDH1/2 mutations were significantly associated with WHO PS >2 (p < 0.001) and non-complex karyotype (p = 0.021) when compared to IDH1/2-WT. Furthermore, patients with IDH1 mutations were more frequently NPM1-mutated (p = 0.007) and had a higher platelet count (p = 0.036). At relapse, IDH1/2 mutations were detected in 6 (25%) patients. As per the outcome, 60.5% of IDH1/2-mutated patients achieved complete remission; overall survival and event-free survival at 2 years were 44.5% and 36.1%, respectively: these rates were similar to IDH1/2-WT. In IDH1/2-mutated patients, high WBC proved to be an independent prognostic factor for survival. In conclusion, the GIMEMA AML1516 confirms that IDH1/2 mutations are frequently detected at diagnosis and underlines the importance of recognizing IDH1/2-mutated cases up-front to offer the most appropriate therapeutic strategy, given the availability of IDH1/2 inhibitors

Quale innovazione

Il volume raccoglie una serie di saggi di autori appartenti a diversi settori scientifici sul tema dell'innovazione e sul significato che questa parola ha nei vari campi del sapere. Il tema dell'innovazione è stato diviso in quattro sotto temi: 1. Nuovi modi d'uso del territorio, 2. Nuovi aspetti della rappresentazione, 3. Nuovi scenari per l'habitat contemporaneo, 4. Nuovi 'confort' nel moderno e nel contemporaneo Per ciascuno di questi temi si sono confrontati autori di diverse provenienze disciplinari, con l'intenzione di offrire uno sguaro più sfaccettao e favorire "trasferimenti" dei saperi. L'articolo introduce il tema dell'innovazione, spostando l'attenzione dalle grandi invenzioni hi-tech degli anni '80 del secolo scorso alla dimensione del quotidiano, laddove piccole innovazioni, portate avanti dalla prassi comune, divengono un motore di innovazione costante e inarrestabile. Architettura dei grandi maestri, dunque, ma anche architettura del quotidiano come pratica costante di buona qualità

The second life of the project

La pubblicazione costituisce il resoconto di un workshop internazionale, svoltosi a Copenhagen nel 2009, parallelamente alla Copenhagen Climate Change Conference - December 2009, La Facoltà di Architettura di Copenhagen e l'UIA hanno invitato docenti-ricercatori delle diverse scuole di architettura europeea svolgere interventi sul tema del progetto urbano sostenibile. Lo scritto esplicita i temi della riqualificazione urbana, mettendo l'accento sulla possibilità che le tecnologie ambientali, in un'ottica di programmazione urbana, possano svolgere un ruolo importante per il miglioramento della qualità della vita nelle città

Progetto di Piazza San Cosimato

Il libro descrive e illustra gran parte dei progetti di spazi pubblici realizzati a Roma negli ultimi dieci anni. Piazza San Cosimato è uno dei più importanti in quanto investe uno dei quartieri storici della città, mettendo in sinergia funzioni di relazione (mercato, gioco bambini, commercio) con il recupero di spazi legati alla storia della piazza

Mountain Settlements: Energy Efficiency and Tourist Needs

Paragraphs: 1) NZEM (Nearly Zero Energy Mountains); 2) Rebalancing Mountain Territories; 3) An Innovative Process to Promote Culture and Technology for Sustainability. Climate change is reconfiguring the geography of mountain areas to such an extent that, beyond the obvious changes in meteorological conditions and the reduction in snow cover, it is capable of modifying habitats at high elevations, allowing natural species from lower elevations to live there. This phenomenon substantially changes the way of perceiving the mountain, both concerning tourist fluxes - which are modified in relation to different seasonal climate conditions - and the people that live in such places and draw their greatest wealth from cultivation of the lands. The questions to be answered are the following: 1. What strategies should be adopted to reduce the energy needs and emissions of CO2 in locations with high tourist fluxes? 2. How can tourist fluxes be balanced (thus balancing consumption and emission) with the aim of favouring other needs linked to a brand of tourism that is more ecologically oriented and economically accessible? 3. How can the necessary technology be integrated to obtain a near-zero energy balance within languages and cultures (material and non-material) characterised by a strong tradition