14 research outputs found
MALARIA RESISTANCE AND SICKLE CELL TRAIT: A REVIEW
Sickle cell disease or sickle cell anaemia is an autosomal recessive disease caused by haemoglobin S, an oxygen-carrying protein in blood cells. A single point mutation in the nucleobase sequence of chromosome 11 (Eleven) causes the sixth amino acid in the haemoglobin protein, glutamine acid, to be replaced by valine, changing standard haemoglobin beta into haemoglobin S. Translocation of sickle cell erythrocyte MicroRNAs into plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Elucidation of this mechanism can lead to a better understanding of sickle cell trait protection against plasmodium falciparum infection