Predicted and observed monthly rates for all-cause OM and for all-other causes for children aged 2 to 23 months in the post-vaccination period.

<p>Interrupted time-series analysis. Goiânia, August 2011-July 2015.</p

Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil - Fig 1

<p>Trends in observed (black lines) and predicted (gray lines) OM (Panel A), and all-cause otitis (Panel B) outpatient visits monthly rates per 100,000 children. Dashed gray lines represent the 95%CI for the predicted rates in the post-vaccination period. The gray bar represents the transition period (August 2010 to July 2011), which was excluded from the time-series analysis.</p

Population, case-counts and rates for all-cause OM outpatient visits and all-other causes in children aged 2 to 23 months.

<p>Goiânia, Brazil, August 2008-July 2015.</p

Percentage change in rates for pneumonia hospitalization and comparison groups, and relative percentage change (PCV10 impact) with respective confidence intervals, by age-group.

<p>Brazil, 2011–2015.</p

Trends in observed (black lines), fit curve (red lines in the pre-vaccination period), and predicted (red lines in the post-vaccination period) pneumonia hospitalization monthly rates per 100,000 population by age-groups in Brazil.

<p>Pre-vaccination period: 2005–2009; Transition period: 2010 (year of PCV10 introduction); Post-vaccination period: 2011–2015. Routine infant PCV10 vaccination was introduced through March to September 2010 by the National Immunization Program. The yellow bar represents the transition period which was excluded from the time-series analysis. Gray bar highlights the months excluded of the flu pandemic months (April-October 2009) from the model.</p

Annual relative percentage change on pneumonia hospitalizations by age-group in the post-vaccination period.

<p>Brazil, 2011–2015.</p

Average annual pneumonia rates (per 100,000 population) of pneumonia hospitalizations in the pre- and post-PCV10 vaccination periods, by age-groups. Brazil, 2005–2015.

<p>Average annual pneumonia rates (per 100,000 population) of pneumonia hospitalizations in the pre- and post-PCV10 vaccination periods, by age-groups. Brazil, 2005–2015.</p

Annual rates (per 100,000 population) of pneumonia and comparison group hospitalizations, by age-group. Brazil, 2005–2015.

<p>Annual rates (per 100,000 population) of pneumonia and comparison group hospitalizations, by age-group. Brazil, 2005–2015.</p