The Extended Shapes of Galactic Satellites

We are exploring the extended stellar distributions of Galactic satellite galaxies and globular clusters. For seven objects studied thus far, the observed profile departs from a King function at large r, revealing a ``break population'' of stars. In our sample, the relative density of the ``break'' correlates to the inferred M/L of these objects. We discuss opposing hypotheses for this trend: (1) Higher M/L objects harbor more extended dark matter halos that support secondary, bound, stellar ``halos''. (2) The extended populations around dwarf spheroidals (and some clusters) consist of unbound, extratidal debris from their parent objects, which are undergoing various degrees of tidal disruption. In this scenario, higher M/L ratios reflect higher degrees of virial non-equilibrium in the parent objects, thus invalidating a precept underlying the use of core radial velocities to obtain masses.Comment: 8 pages, including 2 figures Yale Cosmology Workshop: The Shapes of Galaxies and Their Halo

Absolute Proper Motions to B~22.5: V. Detection of Sagittarius Dwarf Spheroidal Debris in the Direction of the Galactic Anticenter

We have detected a population of predominantly blue (B-V <= 1.1) stars in the direction l = 167 deg., b = -35 deg. (Kapteyn Selected Area 71) that cannot be accounted for by standard starcount models. Down to V ~ 20, the colors and magnitudes of these stars are similar to those of the southern overdensity detected by the Sloan Digital Sky Survey, and identified as stripped material from the Sagittarius dwarf spheroidal galaxy. We present absolute proper motions for the stars in SA 71, and we find that the excess blue stars represent a distinct, kinematically cooler component than the Galactic field, and in reasonable agreement with predictions of Sgr disruption models. The density of the excess SA 71 stars at V ~ 18.8 and B-V <=1.1 is within a factor of two of the density of the SDSS-south Sgr stripped material, and of that predicted by the Helmi and White disruption model. Three additional anticenter fields (SA 29, 45 and 118) show very good agreement with standard starcount models.Comment: 13 pages, 3 figures, submitted to ApJL, accepted for Ap

Exploring Halo Substructure with Giant Stars IV: The Extended Structure of the Ursa Minor Dwarf Spheroidal

We present a large area photometric survey of the Ursa Minor dSph. We identify UMi giant star candidates extending to ~3 deg from the center of the dSph. Comparison to previous catalogues of stars within the tidal radius of UMi suggests that our photometric luminosity classification is 100% accurate. Over a large fraction of the survey area, blue horizontal branch stars associated with UMi can also be identified. The spatial distribution of both the UMi giant stars and the BHB stars are remarkably similar, and a large fraction of both samples of stars are found outside the tidal radius of UMi. An isodensity contour map of the stars within the tidal radius of UMi reveals two morphological peculiarities: (1) The highest density of dSph stars is offset from the center of symmetry of the outer isodensity contours. (2) The overall shape of the outer contours appear S-shaped. We find that previously determined King profiles with ~50' tidal radii do not fit well the distribution of our UMi stars. A King profile with a larger tidal radius produces a reasonable fit, however a power law with index -3 provides a better fit for radii > 20'. The existence of UMi stars at large distances from the core of the galaxy, the peculiar morphology of the dSph within its tidal radius, and the shape of its surface density profile all suggest that UMi is evolving significantly due to the tidal influence of the Milky Way. However, the photometric data on UMi stars alone does not allow us to determine if the candidate extratidal stars are now unbound or if they remain bound to the dSph within an extended dark matter halo. (Abridged)Comment: accepted by AJ, 32 pages, 15 figures, emulateapj5 styl

Exploring Halo Substructure with Giant Stars. X. Extended Dark Matter or Tidal Disruption?: The Case for the Leo I Dwarf Spheroidal Galaxy

We present a wide-field (4.5 deg^2) photometric and spectroscopic survey of the Leo I dwarf spheroidal (dSph) galaxy to explore its extended morphology and dynamics. To select Leo I red giant branch star candidates we exploit M, T_2, and DDO51 filter photometry; this yields 100% pure Leo I stars among more than 100 M < 21.5 Leo I giant candidates having previous or new Keck spectroscopy. The two-dimensional distribution of all photometric Leo I giant candidates is well fitted by a single-component King profile of limiting radius 13.4' out to a major axis radial distance of ~10', but beyond this point the density profile shows an excess of stars along the major axis of the main body. This spatial configuration, together with a rather flat velocity dispersion profile and an asymmetric radial velocity distribution among Leo I members at large radii, supports a picture where Leo I has been tidally disrupted on one or two perigalactic passages about a massive Local Group member. We demonstrate this hypothesis using mass-follows-light, N-body simulations of satellites in a Milky Way-like potential that reproduce the observed structural and dynamical properties of Leo I remarkably well. These models include ~3 × 10^7 solar mass, tidally disrupting dSphs on bound orbits with rather high eccentricity (0.93-0.96) and small perigalactica (10-15 kpc). The simulations yield an observationally constrained orbit for Leo I without the measurement of its proper motion. Given the overall success of our satellite models to account for the observed properties of Leo I, we conclude that there is no need to invoke an extended dark matter halo around the satellite and that an overall modest M/L for the satellite is consistent with the available data

The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases

Background: The intent of this pooled analysis as part of the German society for radiation oncology (DEGRO)stereotactic body radiotherapy (SBRT) initiative was to analyze the patterns of care of SBRT for liver oligometastases and to derive factors influencing treated metastases control and overall survival in a large patient cohort. Methods: From 17 German and Swiss centers, data on all patients treated for liver oligometastases with SBRT since its introduction in 1997 has been collected and entered into a centralized database. In addition to patient and tumor characteristics, data on immobilization, image guidance and motion management as well as dose prescription and fractionation has been gathered. Besides dose response and survival statistics, time trends of the aforementioned variables have been investigated. Results: In total, 474 patients with 623 liver oligometastases (median 1 lesion/patient; range 1–4) have been collected from 1997 until 2015. Predominant histologies were colorectal cancer (n= 213 pts.; 300 lesions) and breast cancer (n= 57; 81 lesions). All centers employed an SBRT specific setup. Initially, stereotactic coordinates and CT simulation were used for treatment set-up (55%), but eventually were replaced by CBCT guidance (28%) or more recently robotic tracking (17%). High variance in fraction (fx) number (median 1 fx; range 1–13) and dose per fraction (median: 18.5 Gy; range 3–37.5 Gy) was observed, although median BED remained consistently high after an initial learning curve. Median follow-up time was 15 months; median overall survival after SBRT was 24 months. One- and 2-year treated metastases control rate of treated lesions was 77% and 64%; if maximum isocenter biological equivalent dose (BED) was greater than 150 Gy EQD2Gy, it increased to 83% and 70%, respectively. Besides radiation dose colorectal and breast histology and motion management methods were associated with improved treated metastases control

A frameshift mutation of the chloroplast matK coding region is associated with chlorophyll deficiency in the Cryptomeria japonica virescent mutant Wogon-Sugi

Wogon-Sugi has been reported as a cytoplasmically inherited virescent mutant selected from a horticultural variety of Cryptomeria japonica. Although previous studies of plastid structure and inheritance indicated that at least some mutations are encoded by the chloroplast genome, the causative gene responsible for the primary chlorophyll deficiency in Wogon-Sugi, has not been identified. In this study, we identified this gene by genomic sequencing of chloroplast DNA and genetic analysis. Chloroplast DNA sequencing of 16 wild-type and 16 Wogon-Sugi plants showed a 19-bp insertional sequence in the matK coding region in the Wogon-Sugi. This insertion disrupted the matK reading frame. Although an indel mutation in the ycf1 and ycf2 coding region was detected in Wogon-Sugi, sequence variations similar to that of Wogon-Sugi were also detected in several wild-type lines, and they maintained the reading frame. Genetic analysis of the 19 bp insertional mutation in the matK coding region showed that it was found only in the chlorophyll-deficient sector of 125 full-sibling seedlings. Therefore, the 19-bp insertion in the matK coding region is the most likely candidate at present for a mutation underlying the Wogon-Sugi phenotype

The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Background: The aim of this analysis was to model the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer. Methods: The analysis is based on pooled data from two retrospective SBRT databases for pulmonary and hepatic metastases from 27 centers from Germany and Switzerland. Only patients with metastases from colorectal cancer were considered to avoid histology as a confounding factor. An illness-death model was employed to model the relationship between LC and OS. Results: Three hundred eighty-eight patients with 500 metastatic lesions (lung n = 209, liver n = 291) were included and analyzed. Median follow-up time for local recurrence assessment was 12.1 months. Ninety-nine patients with 112 lesions experienced local failure. Seventy-one of these patients died after local failure. Median survival time was 27.9 months in all patients and 25.4 months versus 30.6 months in patients with and without local failure after SBRT. The baseline risk of death after local failure exceeds the baseline risk of death without local failure at 10 months indicating better survival with LC. Conclusion: In CRC patients with lung or liver metastases, our findings suggest improved long-term OS by achieving metastatic disease control using SBRT in patients with a projected OS estimate of &gt; 12 months