Activity, structural features and in silico digestion of antidiabetic peptides

Funding This research was funded by the grant PID2020-114137RB-I00 funded by MCIN/AEI/10.13039/501100011033Food antidiabetic peptides inhibit the enzymes involved in the regulation of the glycemic index (e.g. a-amylase, a-glucosidase and dipeptidyl peptidase-IV (DPP-IV)). This work reviews the antidiabetic peptide sequences reported in the literature, with activity confirmed by using synthetic peptides, and critically discusses their structural features. Moreover, it provides an overview of the potency of in silico analysis tools to predict the in vitro antidiabetic activity of DPP-IV-inhibitory peptides. In addition, the potential degradation of the most active peptides during digestion was evaluated in silico. Therefore, this work advances our understanding on the structure-activity relationship of antidiabetic peptides and provides new insights on their stability during digestion.MCIN/AEI/10.13039/501100011033: PID2020-114137RB-I0

Evaluation of Plant Protein Hydrolysates as Natural Antioxidants in Fish Oil-In-Water Emulsions

In this work, we evaluated the physical and oxidative stabilities of 5% w/w fish oil-in-water emulsions stabilized with 1%wt Tween20 and containing 2 mg/mL of protein hydrolysates from olive seed (OSM–H), sunflower (SFSM–H), rapeseed (RSM–H) and lupin (LUM–H) meals. To this end, the plant-based substrates were hydrolyzed at a 20% degree of hydrolysis (DH) employing a mixture 1:1 of subtilisin: trypsin. The hydrolysates were characterized in terms of molecular weight profile and in vitro antioxidant activities (i.e., DPPH scavenging and ferrous ion chelation). After incorporation of the plant protein hydrolysates as water-soluble antioxidants in the emulsions, a 14-day storage study was conducted to evaluate both the physical (i.e., ζ-potential, droplet size and emulsion stability index) and oxidative (e.g., peroxide and anisidine value) stabilities. The highest in vitro DPPH scavenging and iron (II)-chelating activities were exhibited by SFSM–H (IC50 = 0.05 ± 0.01 mg/mL) and RSM–H (IC50 = 0.41 ± 0.06 mg/mL). All the emulsions were physically stable within the storage period, with ζ-potential values below −35 mV and an average mean diameter D[4,3] of 0.411 ± 0.010 μm. Although LUM–H did not prevent lipid oxidation in emulsions, OSM–H and SFSM–H exhibited a remarkable ability to retard the formation of primary and secondary lipid oxidation products during storage when compared with the control emulsion without antioxidants. Overall, our findings show that plant-based enzymatic hydrolysates are an interesting alternative to be employed as natural antioxidants to retard lipid oxidation in food emulsions

Carta de Psicología No. 54

El capital psicológico y el engagement en el trabajo: revisión teórica / Angie Lorena Escobar Giraldo, Carol Valentina Londoño Pantoja y Laura Valentina Rojas Montealegre. Relación entre clima organizacional y engagement desde una mirada del modelo de Avalores en competencia / Karol Sunev Encinales y Angie Julieth Riaño. Relación de los estilos de liderazgo transformacional y transaccional en el clima organizacional: una revisión de la literatura / Leidy Tatiana Javela Avila y Angie Johana Maldonado Bejarano. El bienestar organizacional: una revisión teórica desde lo hedónico y lo eudaimónico / Astrid Carolina Rodríguez Prieto, Daniela Sthefania Pérez Arango y Laura Jimena Mondragón. Estudio comparativo de la normatividad en torno al acoso laboral / Magda Cardozo y Paola Andrea Rubiano. Análisis del estilo lingüístico prosocial y altruista / Luis Fernando Benedetti, Luisa Fernanda Martínez y Juan Camilo Carvajal-Builes. Violencia intrafamiliar como una problemática juvenil en Colombia / María José Saavedra Vargas y Daniela Barbosa Ardila. Análisis psicológico de la trata de personas con fines / María José Saavedra Vargas y Daniela Barbosa Ardila. Sobre el reciclaje: su debida ejecución y su importancia para el medio ambiente / María Camila Londoño Fernández y Camilo Jesús Alejandro Vivas Becerra. Estrategias de aprendizaje espacial con apoyo virtual en hombres y mujeres desde una visión evolutiva / Natalia Pareja Henao, J. Jacobo Pinto Galindo, Esteban Ayala Vargas, Ivonne Edith Alejo Castañeda y Tatiana Manrique Zuluaga. La música favorece la atención en niños / Manuela María del Rocío Pinzón, Laura Geraldine Cortés, Tatiana Manrique Zuluaga e Ivonne Edith Alejo Castañeda. La autorregulación y la autonomía, un abordaje desde la psicología del desarrollo infantil / Diana Paola Pardo Galvis, Lizeth Tatiana Herrera Toro y Julieth María Ospina Osorio. Importancia e incidencia de la vocación y la profesión en el sector social LGBTIQ / Lieen D. Guevara G. Sistema de Responsabilidad Penal para Niños o Adolescentes (SRPA) en Colombia / Diana Paola Pardo Galvis, Lizeth Tatiana Herrera Toro y Erika Natalia Algarra Martínez. Breve revisión de la importancia del desarrollo de los niños, niñas y adolescentes (NNA) y sus derechos de participación dentro del contexto sociopolítico / Daniela Barbosa Ardila y María José Saavedra Vargas. “Verdad y mentira”: conceptos relacionados con el ejercicio de la psicología del testimonio / María Paula Castro y Juan Camilo Carvajal-Builes. Comportamientos de violencia conyugal naturalizados por jóvenes universitarios de Bogotá / Daniela Alejandra Martínez Sarmiento, María Fernanda Nieto Ramírez, Laura Andrea Torres Pulido, María Emily Triana Jiménez y Darío León Rincó