Protective effects of pomiferin isolated from Maclura pomifera on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation

Background: The aim of this study was to investigate the antioxidant and anti-inflammatory properties of pomiferin, a prenylated flavonoid was purified from Maclura pomifera by thin layer chromatography method, on oxidative stress, sterile inflamation and ovarian tissue damage caused by ischemia-reperfusion model. Methods: Thirty female Wistar albino rats were divided into five groups. In the group CN only laparotomy operation was performed. In group CNPomiferin, rats received 200 mg/kg pomiferin. In group IRVehicle, reperfusion for 3 h performed after an ischemic period of 3 hours. In groups IRPomiferin100 and IRPomiferin200 rats received 100 mg/kg and 200 mg/kg doses of pomiferin, by oral gavage 1 houes before reperfusion. After the experiments, tissue level of malondialdehyde (MDA) and activities of myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD) were determined, and histopathological changes were examined in all rat ovarian tissue. Results: It was determined that irreversible cell damage such as apoptotic and necrotic deaths and reversible cell damage occurred in follicular, endothelial and stromal cells due to oxidative stress in the group IRVehicle. In this group, it was determined that the LPO level exceeded the cellular antioxidant capacity (SOD and CAT enzyme activities) and the PMNL infiltration and activity (MPO), an indicator of sterile inflammation, increased. It was determined that oxidative stress sterile inflammation and irreversible cell damage decreased in a dose-dependent manner with pomiferin treatment. Conclusions: Pomipherin treatment strongly protects ovarian follicles and vascular structures against ischemia-reperfusion injury, thus it may prevent the reduction of ovarian follicle reserve, which is an indicator of female fertility

CT Findings of Patients with Small Bowel Obstruction due to Bezoar: A Descriptive Study

Purpose. The aim of this study was to present the computed tomography (CT) findings of bezoars that cause obstruction in the small bowel and to emphasize that some CT findings can be considered specific to some bezoar types. Materials and Methods. The records of 39 patients who underwent preoperative abdominal CT and subsequent operation with a diagnosis of intestinal obstruction due to bezoars were retrospectively analyzed. Results. In total, 56 bezoars were surgically removed from 39 patients. Bezoars were most commonly located in the jejunum (n=26/56, 46.4%). Sixteen (41.0%) patients had multiple bezoar locations in the gastrointestinal tract. Common CT findings in all patients were a mottled gas pattern and a focal ovoid or round intraluminal mass with regular margins and a heterogeneous internal structure. Furthermore, some CT findings were determined to be specific to bezoars caused by persimmons. Conclusions. Preoperative CT is valuable in patients admitted with signs of intestinal obstruction in geographic regions with a high bezoar prevalence. We believe that the correct diagnosis of bezoars and the identification of their number and location provide a great advantage for all physicians and surgeons. In addition, some types of bezoars have unique CT findings, and we believe that these findings may help to establish a diagnosis

Lung tissue apoptosis in abdominal hypertension

Objectives The aim of this study was to evaluate lung tissue histopathologic changes and the number of apoptosis with the increase of abdominal pressure. Methods The study rats were randomly assigned into the following five groups: a sham operated group and groups 1, 2, 3 and 4, in which the intra-abdominal pressure was increased to 11, 15, 18 and 22 mmHg for 60 min, respectively. Lungs were harvested for histopathologic changes and the tissue apoptotic analysis were carried out in a blinded manner. Results All of the data showed that the number of apoptotic cells and necrosis were increased in accordance with the pressure level. However, this increase was statistically significant, especially in groups 3 and 4 (18 and 22 mmHg, respectively; p < 0.05) when compared to the sham operated rats. There were no differences observed between groups 1 and 2 (11 and 15 mmHg, respectively) and the sham operated rats. There was also no difference between groups 1 and 2. There were findings of coagulation necrosis and the number of apoptotic cells linearly increased when the abdominal pressure was increased. The cut-off value was 15 mmHg. Conclusion The available findings suggest that intra-abdominal pressure greater than 15 mmHg could irreversibly damage pulmonary cells and both coagulation necrosis parameters and the number of apoptosis increase in accordance with the pressure level

Topical Steroids Are Effective in the Treatment of Idiopathic Granulomatous Mastitis

Topical steroids seem to be effective in the treatment of IGM characterized by skin changes. Prospective clinical studies would be useful in determining the clinical efficacy of topical steroids in the treatment of IGM

Pancreatic tumor metastasis to the navel in a case with three primary tumors – case report and review of the literature

Introduction. Sister Mary Joseph nodule (SMJN) is a metastasis that can occur in the umbilical region due to many tumors in the abdomen. Most of the cases are of gastrointestinal system origin and are often an indicator of poor prognosis. It can be seen in 1-3% of intraabdominal and pelvic malignancies. In the literature, around 300 studies are presented, mostly in the form of case reports. Very few (7-9%) of the cases with SMJN are from pancreatic origin. In our literature review, we found that in the majority (>90%) of SMJN cases due to pancreatic tumors, the lesions originated from the pancreatic tail and/or body, and tumor marker Ca-19.9 was very high in most cases (>90%). Aim. Here, the case of SMJN seen in a patient with three different primary tumors was discussed in the light of the literature data. Description of the case. Here, our case, whose third primary malignancy was detected in the pancreas in the PET/CT examination performed to investigate the origin of SMJN in a 68-year-old female patient who had undergone surgery due to breast in 2011 and endometrium cancers in 2018 and came with umbilical metastasis, is presented in the light of the literature data. Conclusion. As a result, in our case, which was followed up due to two primary tumors, it became important to know the origin of the SMJN that occurred due to the third primary tumor detected during the CT and PET/CT examination due to the newly emerging SMJN. It is important to know the origin and histopathological features of the SMJN in order to determine the treatment to the patien

Renal cytokine and histopathologic changes following acutely increased intra-abdominal pressure: an animal study

Abdominal tension linearly can cause renal tubular histopathologic changes. Cytokines may play a role in ARF due to ACS

Comparision of the Limberg flap with the V-Y flap technique in the treatment of pilonidal disease

Conclusion: The early postoperative and long-term results of the LF and V-Y flap techniques for the treatment of pilonidal sinus were similar. Because the resumption of daily activities at work is achieved later in patients undergoing the V-Y flap compared with the LF technique, patients' employment (or position in working life) must be considered when determining the most appropriate surgical technique

Renal cytokine and histopathologic changes following acutely increased intra-abdominal pressure: an animal study

Abdominal tension linearly can cause renal tubular histopathologic changes. Cytokines may play a role in ARF due to ACS

Psödoanevrizmayı taklit eden bir malign fibröz histiositoma olgusu

Malign fibröz histiositoma, erişkinlerde görülen en sık yumuşak doku tümörüdür. Psödoanevrizma ise arter duvarı rüptürü sonucu gelişir. Her iki lezyon da ekstremitede bir kitle şeklinde kendini gösterir. Burada psödoanevrizmayı taklit eden bir malign fibröz histiositoma olgusunu sunarak, bu iki farklı lezyonun benzerlikleri ve farklılıklarını tartışıyoruz.Malignant fibrous histiocytoma is the most common soft tissue tumor encountered in adults. A pseudoaneurysm is defined as a contained rupture of the artery wall. Each lesion may be present as a mass in the extremities. We present a case with malignant fibrous histiocytoma mimicking pseudoaneurysm, and discuss similarities and differences of these different lesions