Suicide risk in long‐term care facilities: a systematic review

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109565/1/gps4142.pd

Expressions 1981

Expressions contains selected work from the 1981 Creative Writing Contest entrants, Campus Chronicle Photography Contest entrants, and Commercial Art students at Des Moines Area Community College. Design , typography and the layout was done by Journalism students .https://openspace.dmacc.edu/expressions/1003/thumbnail.jp

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes

Development of a Participatory Interactive Documentary: The Vietnam War from All Sides

“The Vietnam War/American War: Stories from All Sides” is a transmedia project that includes a PBS style documentary and participatory website. Initially funded through an IU New Frontiers Grant, currently more than 135 oral history film interviews have been recorded with veterans and marginalized individuals from all sides of the war. More than 40 of these interviews were recorded in Vietnam with our former enemy. This presentation will concentrate on the development of the project, with emphasis on the prototype website. The website includes a playlist feature that allows users to assemble their own movie sequences based on topic, geographic location, time period or name searches. Attendees will have the opportunity to discuss the effectiveness of this type of information delivery

Vietnam War Stories from All Sides: Moving to Media Collections Online

The Vietnam War: Stories from All Sides began as an oral history project telling stories from American & Vietnamese veterans, refugees and others impacted by the war. Ron Osgood initiated the project through an Institute for Digital Arts & Humanities (IDAH) Fellowship and a New Frontiers Grant. Over the past 10 years, more than 150 oral history interviews have been recorded, a prototype website for educational use created and a documentary film produced. Currently, Osgood is working with Jon Cameron to upload the 150 oral history interviews to the IU Libraries’ Media Collections Online service. In addition to providing long-term preservation for the media and an institutionally owned platform for hosting, website embeds are also being migrated from YouTube to Media Collections Online