Demographics and viro-immunological status of the population studied.

<p>Values are expressed as median and interquartile range, unless indicated. HALS = HIV-1/HAART-associated lipodystrophy syndrome, MsM = men who have sex with men, HTSX = heterosexuals, IDU = intravenous drug users, AIDS = acquired immune deficiency syndrome, HCV = hepatitis C virus, HBV = hepatitis B virus, ml = millilitres.</p

Anthropometric, metabolic and fat data in d4T-exposed patients.

<p>All values expressed as median and (interquartile range) unless specified.</p><p>HALS = HIV-1/HAART-associated lipodystrophy syndrome, BMI = body mass index, WHR = waist-hip ratio, LSGS = lipodystrophy grade severity score, BP = blood pressure, mmol/l = milimoles per litre, HDL = high density lipoprotein, LDL = low density lipoprotein, VLDL = very low density lipoprotein, pmol/l = picomoles per litre, HOMA-r = homeostasis model assessment, g = grams.</p

Gene polymorphisms associated with the presence of HALS in d4T-exposed patients.

<p>HALS = HIV/HAART-associated lipodystrophy syndrome, TS = thymidylate synthase, MTHFR = methylene-tetrahydrofolate reductase,</p>*<p>Heterozygous and wild-type patients,</p>†<p>Homozygous 677T, homozygous 1298C and compound heterozygous patients.</p

d4T-TP intracellular levels according to TS and MTHFR genotypes, and HLA B^*-40∶01 carriage.

<p>Values are expressed as median (interquartile range) unless otherwise indicated. TS = thymidylate synthase, MTHFR = methylene-tetrahydrofolate reductase,</p>*<p>Heterozygous and wild-type patients,</p>†<p>Homozygous 677T, homozygous 1298C and compound heterozygous patients.</p