Investigation of the Therapeutic Effect of Tobramycin in Mice with Experimental Pneumonia in One-shot Versus Divided-dose Schedules

We measured the plasma levels of tobramycin administered by different methods and evaluated the therapeutic effects of tobramycin in mice with experimental pneumonia in various methods and dose schedules. (1) Mice were dosed with tobramycin intramuscular, intravenous oneshot injection and drip infusion, and intramuscular injection in divided doses at intervals of 15 minutes. The plasma concentration of the drug was determined at timed intervals after administration in each instance. Intramuscular and one-shot intravenous injections resulted in substantially parallel time courses of plasma concentration and plasma concentration with drip infusion was similar to that after divided intramuscular injection. (2) A therapeutic experiment was conducted in mice with Klebsiella pneumoniae pneumonia using one-shot and divided intramuscular injection methods of tobramycin. The one-shot injection group showed a satisfactory result at the dose level of 2 mg/kg, but the injection in four divided doses yielded better results at 1 mg/kg. Therefore, in cases where high doses are not feasible or are undesirable, the time of contact of the bacteria and the drug should be prolonged, rather than trying to increase the peak plasma concentration of the drug

Spectroscopic Observations of the WZ Sge-Type Dwarf Nova GW Librae during the 2007 Superoutburst

We carried out an international spectroscopic observation campaign of the dwarf nova GW Librae (GW Lib) during the 2007 superoutburst. Our observation period covered the rising phase of the superoutburst, maximum, slowly decaying phase (plateau), and long fading tail after the rapid decline from the plateau. The spectral features dramatically changed during the observations. In the rising phase, only absorption lines of H$\alpha$, H$\beta$, and H$\gamma$ were present. Around the maximum, the spectrum showed singly-peaked emission lines of H$\alpha$, He I 5876, He I 6678, He II 4686, and C III/N III as well as absorption lines of Balmer components and He I. These emission lines significantly weakened in the latter part of the plateau phase. In the fading tail, all the Balmer lines and He I 6678 were in emission, as observed in quiescence. We find that the center of the H$\alpha$ emission component was mostly stable over the whole orbital phase, being consistent with the low inclination of the system. Comparing with the observational results of WZ Sge during the 2001 superoutburst, the same type of stars as GW Lib seen with a high inclination angle, we interpret that the change of the H$\alpha$ profile before the fading tail phase is attributed to a photoionized region formed at the outer edge of the accretion disk, irradiated from the white dwarf and inner disk.Comment: 10 pages, 9 figures, accepted for publication in PAS

Undergraduate educational environment, perceived preparedness for postgraduate clinical training, and pass rate on the National Medical Licensure Examination in Japan

<p>Abstract</p> <p>Background</p> <p>We investigated the views of newly graduating physicians on their preparedness for postgraduate clinical training, and evaluated the relationship of preparedness with the educational environment and the pass rate on the National Medical Licensure Examination (NMLE).</p> <p>Methods</p> <p>Data were obtained from 2429 PGY-1 physicians-in-training (response rate, 36%) using a mailed cross-sectional survey. The Dundee Ready Education Environment Measure (DREEM) inventory was used to assess the learning environment at 80 Japanese medical schools. Preparedness was assessed based on 6 clinical areas related to the Association of American Medical Colleges Graduation Questionnaire.</p> <p>Results</p> <p>Only 17% of the physicians-in-training felt prepared in the area of general clinical skills, 29% in basic knowledge of diagnosis and management of common conditions, 48% in communication skills, 19% in skills associated with evidence-based medicine, 54% in professionalism, and 37% in basic skills required for a physical examination. There were substantial differences among the medical schools in the perceived preparedness of their graduates. Significant positive correlations were found between preparedness for all clinical areas and a better educational environment (all p < 0.01), but there were no significant associations between the pass rate on the NMLE and perceived preparedness for any clinical area, as well as pass rate and educational environment (all p > 0.05).</p> <p>Conclusion</p> <p>Different educational environments among universities may be partly responsible for the differences in perceived preparedness of medical students for postgraduate clinical training. This study also highlights the poor correlation between self-assessed preparedness for practice and the NMLE.</p