Anisotropies and Low-temperature Annealing Effect in Cold-rolled Nickel-Silver Alloy

The changes in hardness, elastic modulus and bending deflection with rolling reduction and with low-temperature annealing of nickel-silver were measured on the specimens cut parallel and transverse to the rolling direction of the sheet, and the results were considered in relation to the rolling structure. The anisotropies become more remarkable as the rolling reduction exceeds 50 per cent, and, in this region, the measured values are always higher in the transverse than in the other direction. This may be due to the development of the rolling texture and to the appearance of the flaw-like strain markings in the transverse direction. The low-temperature annealing makes the values of hardness and elastic modulus increase, and the maximum values are, in either case, obtained by heat-treatment at 350℃. Also, the larger the rolling reduction is, the higher the increasing ratio becomes. The change in hardness due to low-temperature annealing is larger as the grain size reduces, whereas the change in elasticity is hardly affected by the grain size. The anneal-hardening at each temperature does not show the two-stage hardening which has been observed in α-brass sheet, but shows a simple and smooth process. No difference in microstructure can be observed between as cold-rolled and as anneal-hardened state, although, in the previous work on α-brass, some structural changes thought to be a kind of polygonization were recognized after low-temperature annealing. The results of bending test correspond with those of elastic modulus

Spin-dependent observables in surrogate reactions

Observables emitted from various spin states in compound U nuclei are investigated to validate usefulness of the surrogate reaction method. It was found that energy spectrum of cascading $\gamma$-rays and their multiplicities, spectrum of evaporated neutrons, and mass-distribution of fission fragments show clear dependence on the spin of decaying nuclei. The present results indicate that they can be used to infer populated spin distributions which significantly affect the decay branching ratio of the compound system produced by the surrogate reactions

Irinotecan Hydrochloride (CPT-11) in Dialysis Patients with Gastrointestinal Cancer

We investigated changes in drug disposition and toxicities with CPT-11 in 15 dialysis patients with gastrointestinal cancers to clarify whether CPT-11 could be administered safely in such patients. For comparison, the same parameters were also investigated in 10 cancer patients not undergoing dialysis. Items investigated included (1) plasma concentrations of SN-38, SN-38G and CPT-11 at 0, 1, 12, 24, 36, 48 and 72h after administration, together with a comparison of mean AUC values for 3 dose levels of CPT-11 (50, 60 and 70mg/m2) in dialysis patients and controls;and (2) occurrence of adverse events. Several findings emerged from this study:(1) No significant difference was observed in the AUC for SN-38 or CPT-11 between the dialysis and control groups;(2) The AUC for SN-38G at each dose was significantly higher in dialysis patients;and (3) Grade 1-4 leucopenia was observed in 11 of the dialysis patients. One patient developed grade 4 leucopenia and died due to sepsis. Anorexia, diarrhea, nausea, alopecia and interstitial pneumonia occurred in 6 dialysis patients. We found changes in drug dispositions of CPT-11, SN-38 and SN-38G in dialysis patients, suggesting that hepatic excretion, especially that of SN-38G, was increased. No significant difference in occurrence of adverse events was observed between the 2 groups. This indicates that CPT-11 can be administered safely in patients on dialysis.</p